dbPTM

SIA8D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIA8D_HUMAN
UniProt AC	Q92187
Protein Name	CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
Gene Name	ST8SIA4
Organism	Homo sapiens (Human).
Sequence Length	359
Subcellular Localization	Golgi apparatus membrane Single-pass type II membrane protein .
Protein Description	Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells..
Protein Sequence	MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MRSIRKRWTI -----CCCHHHHHHH	26.00	26437602
28	O-linked_Glycosylation	KTKEIARTEEHQETQ HHHHHHCCCCHHCEE	36.38	OGP
43	Phosphorylation	LIGDGELSLSRSLVN EECCCCCCCCHHHHC	21.72	24719451
45	Phosphorylation	GDGELSLSRSLVNSS CCCCCCCCHHHHCCC	19.22	17081983
50	N-linked_Glycosylation	SLSRSLVNSSDKIIR CCCHHHHCCCHHHHH	40.88	11279095
50	N-linked_Glycosylation	SLSRSLVNSSDKIIR CCCHHHHCCCHHHHH	40.88	11279095
58	Ubiquitination	SSDKIIRKAGSSIFQ CCHHHHHHHCCCHHC	46.84	29967540
74	N-linked_Glycosylation	NVEGWKINSSLVLEI CCCCCEECCHHHHHH	23.09	11279095
74	N-linked_Glycosylation	NVEGWKINSSLVLEI CCCCCEECCHHHHHH	23.09	11279095
99	Ubiquitination	ERDVSVVKSSFKPGD CCCHHHHHCCCCCCC	37.92	-
110	Phosphorylation	KPGDVIHYVLDRRRT CCCCEEEEEEECCCC	7.50	-
119	N-linked_Glycosylation	LDRRRTLNISHDLHS EECCCCEECCCCHHH	32.86	10660622
119	N-linked_Glycosylation	LDRRRTLNISHDLHS EECCCCEECCCCHHH	32.86	11279095
132	Phosphorylation	HSLLPEVSPMKNRRF HHHCCCCCCCCCCCC	20.02	24719451
204	N-linked_Glycosylation	RAFGGFRNESDREKF HHHCCCCCHHHHHHH	51.36	11279095
204	N-linked_Glycosylation	RAFGGFRNESDREKF HHHCCCCCHHHHHHH	51.36	11279095
216	Phosphorylation	EKFVHRLSMLNDSVL HHHHHHHHHHCCCEE	22.60	-
219	N-linked_Glycosylation	VHRLSMLNDSVLWIP HHHHHHHCCCEEEEE	30.76	11279095
219	N-linked_Glycosylation	VHRLSMLNDSVLWIP HHHHHHHCCCEEEEE	30.76	11279095
253	Phosphorylation	KNKLKVRTAYPSLRL HCCCHHCCCCCHHHH	33.27	-
267	Phosphorylation	LIHAVRGYWLTNKVP HHHHHCCEEECCCCC	6.15	-
270	Phosphorylation	AVRGYWLTNKVPIKR HHCCEEECCCCCCCC	20.88	-
279	Phosphorylation	KVPIKRPSTGLLMYT CCCCCCCCCHHHHHH	38.86	26503514
280	Phosphorylation	VPIKRPSTGLLMYTL CCCCCCCCHHHHHHH	34.23	26503514
285	Phosphorylation	PSTGLLMYTLATRFC CCCHHHHHHHHHHHC	9.89	20049867
314	Phosphorylation	LNGKAVKYHYYDDLK CCCCEEEEEEECCCC	6.61	26074081
316	Phosphorylation	GKAVKYHYYDDLKYR CCEEEEEEECCCCCE	12.90	26074081
317	Phosphorylation	KAVKYHYYDDLKYRY CEEEEEEECCCCCEE	6.94	26074081
322	Phosphorylation	HYYDDLKYRYFSNAS EEECCCCCEEECCCC	20.17	26074081
327	N-linked_Glycosylation	LKYRYFSNASPHRMP CCCEEECCCCCCCCC	34.24	UniProtKB CARBOHYD
339	Phosphorylation	RMPLEFKTLNVLHNR CCCCEECCHHHHHHC	28.96	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SIA8D_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SIA8D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIA8D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNSL1_HUMAN	DNASE1L1	physical	28514442
SUSD1_HUMAN	SUSD1	physical	28514442
ITA7_HUMAN	ITGA7	physical	28514442
TGBR3_HUMAN	TGFBR3	physical	28514442
ATS2_HUMAN	ADAMTS2	physical	28514442
RN5A_HUMAN	RNASEL	physical	28514442
SEM4D_HUMAN	SEMA4D	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
GLT18_HUMAN	GALNT18	physical	28514442
STK39_HUMAN	STK39	physical	28514442
CNTP3_HUMAN	CNTNAP3	physical	28514442
FA69A_HUMAN	FAM69A	physical	28514442
AMGO1_HUMAN	AMIGO1	physical	28514442
RUFY1_HUMAN	RUFY1	physical	28514442
BACE2_HUMAN	BACE2	physical	28514442
KPCD2_HUMAN	PRKD2	physical	28514442
ITB5_HUMAN	ITGB5	physical	28514442
LCAP_HUMAN	LNPEP	physical	28514442
PLXB2_HUMAN	PLXNB2	physical	28514442
B4GN1_HUMAN	B4GALNT1	physical	28514442
LRP5_HUMAN	LRP5	physical	28514442
NLGN2_HUMAN	NLGN2	physical	28514442
1C07_HUMAN	HLA-C	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
PLXA1_HUMAN	PLXNA1	physical	28514442
FREM2_HUMAN	FREM2	physical	28514442
ITA4_HUMAN	ITGA4	physical	28514442
MKS3_HUMAN	TMEM67	physical	28514442
EPHB4_HUMAN	EPHB4	physical	28514442
BCAM_HUMAN	BCAM	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
MRC2_HUMAN	MRC2	physical	28514442
NRP2_HUMAN	NRP2	physical	28514442
ITA8_HUMAN	ITGA8	physical	28514442
CAHD1_HUMAN	CACHD1	physical	28514442
TECT2_HUMAN	TCTN2	physical	28514442
GPR98_HUMAN	GPR98	physical	28514442
FRAS1_HUMAN	FRAS1	physical	28514442
LARG2_HUMAN	GYLTL1B	physical	28514442
ITAV_HUMAN	ITGAV	physical	28514442
CELR2_HUMAN	CELSR2	physical	28514442
CSTN3_HUMAN	CLSTN3	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
NDST2_HUMAN	NDST2	physical	28514442
HYAL2_HUMAN	HYAL2	physical	28514442
IMPA3_HUMAN	IMPAD1	physical	28514442
PON2_HUMAN	PON2	physical	28514442
K319L_HUMAN	KIAA0319L	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
EGFR_HUMAN	EGFR	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442
FPRP_HUMAN	PTGFRN	physical	28514442
EFTU_HUMAN	TUFM	physical	28514442
LRP6_HUMAN	LRP6	physical	28514442
ADA17_HUMAN	ADAM17	physical	28514442
OAF_HUMAN	OAF	physical	28514442
CD109_HUMAN	CD109	physical	28514442
HMR1_HUMAN	MR1	physical	28514442
BI1_HUMAN	TMBIM6	physical	28514442
IPRI_HUMAN	ITPRIP	physical	28514442
LRP11_HUMAN	LRP11	physical	28514442
FAT1_HUMAN	FAT1	physical	28514442
NRP1_HUMAN	NRP1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIA8D_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Unique disulfide bond structures found in ST8Sia IVpolysialyltransferase are required for its activity."; Angata K., Yen T.Y., El-Battari A., Macher B.A., Fukuda M.; J. Biol. Chem. 276:15369-15377(2001). Cited for: DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-74.	11279095 [Abstract]