| UniProt ID | DNSL1_HUMAN | |
|---|---|---|
| UniProt AC | P49184 | |
| Protein Name | Deoxyribonuclease-1-like 1 | |
| Gene Name | DNASE1L1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 302 | |
| Subcellular Localization | Endoplasmic reticulum . | |
| Protein Description | ||
| Protein Sequence | MHYPTALLFLILANGAQAFRICAFNAQRLTLAKVAREQVMDTLVRILARCDIMVLQEVVDSSGSAIPLLLRELNRFDGSGPYSTLSSPQLGRSTYMETYVYFYRSHKTQVLSSYVYNDEDDVFAREPFVAQFSLPSNVLPSLVLVPLHTTPKAVEKELNALYDVFLEVSQHWQSKDVILLGDFNADCASLTKKRLDKLELRTEPGFHWVIADGEDTTVRASTHCTYDRVVLHGERCRSLLHTAAAFDFPTSFQLTEEEALNISDHYPVEVELKLSQAHSVQPLSLTVLLLLSLLSPQLCPAA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 79 | Phosphorylation | ELNRFDGSGPYSTLS HHCCCCCCCCCCCCC | 38.14 | 24275569 | |
| 82 | Phosphorylation | RFDGSGPYSTLSSPQ CCCCCCCCCCCCCCC | 20.15 | 24275569 | |
| 83 | Phosphorylation | FDGSGPYSTLSSPQL CCCCCCCCCCCCCCC | 26.46 | 24275569 | |
| 93 | Phosphorylation | SSPQLGRSTYMETYV CCCCCCCCCCCEEEE | 23.30 | 25002506 | |
| 94 | Phosphorylation | SPQLGRSTYMETYVY CCCCCCCCCCEEEEE | 26.06 | 25002506 | |
| 95 | Phosphorylation | PQLGRSTYMETYVYF CCCCCCCCCEEEEEE | 8.32 | 25002506 | |
| 98 | Phosphorylation | GRSTYMETYVYFYRS CCCCCCEEEEEEEHH | 11.19 | 25002506 | |
| 99 | Phosphorylation | RSTYMETYVYFYRSH CCCCCEEEEEEEHHC | 4.65 | 25002506 | |
| 101 | Phosphorylation | TYMETYVYFYRSHKT CCCEEEEEEEHHCCC | 5.63 | 25002506 | |
| 103 | Phosphorylation | METYVYFYRSHKTQV CEEEEEEEHHCCCEE | 8.10 | 25002506 | |
| 261 | N-linked_Glycosylation | LTEEEALNISDHYPV CCHHHHHCCCCCCCE | 38.47 | 16107205 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DNSL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DNSL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DNSL1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GFAP_HUMAN | GFAP | physical | 26186194 | |
| SPCS2_HUMAN | SPCS2 | physical | 26186194 | |
| SPCS1_HUMAN | SPCS1 | physical | 26186194 | |
| LRC15_HUMAN | LRRC15 | physical | 26186194 | |
| GFAP_HUMAN | GFAP | physical | 28514442 | |
| SPCS1_HUMAN | SPCS1 | physical | 28514442 | |
| SPCS2_HUMAN | SPCS2 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Physical and biochemical properties of mammalian DNase X proteins:non-AUG translation initiation of porcine and bovine mRNAs for DNaseX."; Shiokawa D., Shika Y., Saito K., Yamazaki K., Tanuma S.; Biochem. J. 392:511-517(2005). Cited for: SUBCELLULAR LOCATION, AND GLYCOSYLATION AT ASN-261. | |
