TSN5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSN5_HUMAN
• UniProt AC: P62079
• Protein Name: Tetraspanin-5
• Gene Name: TSPAN5
• Organism: Homo sapiens (Human).
• Sequence Length: 268
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44..
• Protein Sequence: MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	N-linked_Glycosylation	NEKGVLSNISSITDL CCCCHHCCCCCCHHC	33.72	UniProtKB CARBOHYD
88	Phosphorylation	IGALRENTFLLKFFS HHHHHHCHHHHHHHH	15.77	30301811
158	Ubiquitination	WQCCGAFGADDWNLN HHHHCCCCCCCCEEE	27.80	22817900
169	N-linked_Glycosylation	WNLNIYFNCTDSNAS CEEEEEEECCCCCCC	15.71	UniProtKB CARBOHYD
174	N-linked_Glycosylation	YFNCTDSNASRERCG EEECCCCCCCHHHCC	44.75	UniProtKB CARBOHYD
207	Ubiquitination	CGYDARQKPEVDQQI CCCCCCCCCCCCCEE	37.28	22817900
232	N-linked_Glycosylation	FEKWLQDNLTIVAGI HHHHHHHCHHHHHHH	26.56	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSN5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSN5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSN5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ADA10_HUMAN	ADAM10	physical	23091066
TM248_HUMAN	TMEM248	physical	26186194
VKORL_HUMAN	VKORC1L1	physical	26186194
TM87A_HUMAN	TMEM87A	physical	26186194
ALG8_HUMAN	ALG8	physical	26186194
GDPD1_HUMAN	GDPD1	physical	26186194
THA11_HUMAN	THAP11	physical	26186194
PLCD_HUMAN	AGPAT4	physical	26186194
PLCC_HUMAN	AGPAT3	physical	26186194
S27A2_HUMAN	SLC27A2	physical	26186194
SPCS2_HUMAN	SPCS2	physical	26186194
KLHL2_HUMAN	KLHL2	physical	26186194
TM186_HUMAN	TMEM186	physical	26186194
SOAT1_HUMAN	SOAT1	physical	26186194
AT2B3_HUMAN	ATP2B3	physical	26186194
RDH11_HUMAN	RDH11	physical	26186194
RFT1_HUMAN	RFT1	physical	26186194
GHDC_HUMAN	GHDC	physical	26186194
CTR2_HUMAN	SLC7A2	physical	26186194
TMUB1_HUMAN	TMUB1	physical	26186194
SEC62_HUMAN	SEC62	physical	26186194
EFNB1_HUMAN	EFNB1	physical	26186194
BSCL2_HUMAN	BSCL2	physical	26186194
SC5D_HUMAN	SC5D	physical	26186194
LCLT1_HUMAN	LCLAT1	physical	26186194
CD47_HUMAN	CD47	physical	26186194
SNX25_HUMAN	SNX25	physical	26186194
ZDHC9_HUMAN	ZDHHC9	physical	26186194
LEMD2_HUMAN	LEMD2	physical	26186194
ZDHC6_HUMAN	ZDHHC6	physical	26186194
IMP1L_HUMAN	IMMP1L	physical	26186194
ALG11_HUMAN	ALG11	physical	26186194
NAT8L_HUMAN	NAT8L	physical	26186194
TM192_HUMAN	TMEM192	physical	26186194
RDH12_HUMAN	RDH12	physical	26186194
TMM43_HUMAN	TMEM43	physical	26186194
TM206_HUMAN	TMEM206	physical	26186194
MRM2_HUMAN	FTSJ2	physical	26186194
NDC1_HUMAN	NDC1	physical	26186194
DGLB_HUMAN	DAGLB	physical	26186194
PSN2_HUMAN	PSEN2	physical	26186194
TIM14_HUMAN	DNAJC19	physical	26186194
TV23C_HUMAN	TVP23C	physical	26186194
WDR41_HUMAN	WDR41	physical	26186194
RDH14_HUMAN	RDH14	physical	26186194
B4GT1_HUMAN	B4GALT1	physical	26186194
RER1_HUMAN	RER1	physical	26186194
F210B_HUMAN	FAM210B	physical	26186194
RETR3_HUMAN	FAM134C	physical	26186194
SPCS1_HUMAN	SPCS1	physical	26186194
PIEZ1_HUMAN	PIEZO1	physical	26186194
SCAM2_HUMAN	SCAMP2	physical	26186194
PRAF2_HUMAN	PRAF2	physical	26186194
NB5R3_HUMAN	CYB5R3	physical	26186194
NAT14_HUMAN	NAT14	physical	26186194
GP1BB_HUMAN	GP1BB	physical	26186194
BRI3B_HUMAN	BRI3BP	physical	26186194
KLHL2_HUMAN	KLHL2	physical	28514442
TM248_HUMAN	TMEM248	physical	28514442
NAT8L_HUMAN	NAT8L	physical	28514442
IMP1L_HUMAN	IMMP1L	physical	28514442
RDH12_HUMAN	RDH12	physical	28514442
SNX25_HUMAN	SNX25	physical	28514442
MRM2_HUMAN	FTSJ2	physical	28514442
F210B_HUMAN	FAM210B	physical	28514442
GDPD1_HUMAN	GDPD1	physical	28514442
ZDHC6_HUMAN	ZDHHC6	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
RDH14_HUMAN	RDH14	physical	28514442
WDR41_HUMAN	WDR41	physical	28514442
ZDH21_HUMAN	ZDHHC21	physical	28514442
RETR3_HUMAN	FAM134C	physical	28514442
TM87A_HUMAN	TMEM87A	physical	28514442
PIEZ1_HUMAN	PIEZO1	physical	28514442
AT2B3_HUMAN	ATP2B3	physical	28514442
RDH11_HUMAN	RDH11	physical	28514442
NDC1_HUMAN	NDC1	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
SOAT1_HUMAN	SOAT1	physical	28514442
THA11_HUMAN	THAP11	physical	28514442
SC5D_HUMAN	SC5D	physical	28514442
BSCL2_HUMAN	BSCL2	physical	28514442
CD47_HUMAN	CD47	physical	28514442
ALG8_HUMAN	ALG8	physical	28514442
CTR2_HUMAN	SLC7A2	physical	28514442
LCLT1_HUMAN	LCLAT1	physical	28514442
TIM14_HUMAN	DNAJC19	physical	28514442
PRAF2_HUMAN	PRAF2	physical	28514442
GHDC_HUMAN	GHDC	physical	28514442
GP1BB_HUMAN	GP1BB	physical	28514442
ALG11_HUMAN	ALG11	physical	28514442
S38A2_HUMAN	SLC38A2	physical	28514442
TV23C_HUMAN	TVP23C	physical	28514442
PLCC_HUMAN	AGPAT3	physical	28514442
DGLB_HUMAN	DAGLB	physical	28514442
F213A_HUMAN	FAM213A	physical	28514442
EFNB1_HUMAN	EFNB1	physical	28514442
NAT14_HUMAN	NAT14	physical	28514442
B4GT1_HUMAN	B4GALT1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.