RDH12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RDH12_HUMAN
• UniProt AC: Q96NR8
• Protein Name: Retinol dehydrogenase 12
• Gene Name: RDH12
• Organism: Homo sapiens (Human).
• Sequence Length: 316
• Protein Description: Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments..
• Protein Sequence: MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLVTLGLLTSF ----CCHHHHHHHHH	15.90	24043423
9	Phosphorylation	LVTLGLLTSFFSFLY CHHHHHHHHHHHHHH	28.64	24043423
10	Phosphorylation	VTLGLLTSFFSFLYM HHHHHHHHHHHHHHH	25.02	24043423
13	Phosphorylation	GLLTSFFSFLYMVAP HHHHHHHHHHHHHCH	16.60	24043423
16	Phosphorylation	TSFFSFLYMVAPSIR HHHHHHHHHHCHHHH	6.37	24043423
21	Phosphorylation	FLYMVAPSIRKFFAG HHHHHCHHHHHHHCC	25.86	24043423
45	Phosphorylation	PGKVVVITGANTGIG CCCEEEEECCCCCCC	20.73	24719451
49	Phosphorylation	VVITGANTGIGKETA EEEECCCCCCCHHHH	29.64	24719451
61	Phosphorylation	ETARELASRGARVYI HHHHHHHHCCCEEEE	43.82	24719451
78	Phosphorylation	RDVLKGESAASEIRV HHHHCCCCCCCEEEE	37.49	23403867
81	Phosphorylation	LKGESAASEIRVDTK HCCCCCCCEEEEECC	33.02	23403867
90	Phosphorylation	IRVDTKNSQVLVRKL EEEECCCCEEEEEEC	24.19	28857561
96	Ubiquitination	NSQVLVRKLDLSDTK CCEEEEEECCCCCCH	38.58	-
102	Phosphorylation	RKLDLSDTKSIRAFA EECCCCCCHHHHHHH	24.26	23312004
103	Ubiquitination	KLDLSDTKSIRAFAE ECCCCCCHHHHHHHH	49.21	21890473
103	Ubiquitination	KLDLSDTKSIRAFAE ECCCCCCHHHHHHHH	49.21	21890473
104	Phosphorylation	LDLSDTKSIRAFAEG CCCCCCHHHHHHHHC	21.28	23312004
165	Phosphorylation	LLERLKVSAPARVVN HHHHHCCCCCCEEEE	27.26	26437602
174	Phosphorylation	PARVVNVSSVAHHIG CCEEEEHHHHHHHCC	17.56	26437602
175	Phosphorylation	ARVVNVSSVAHHIGK CEEEEHHHHHHHCCC	21.02	26437602
225	Phosphorylation	LQGTGVTTYAVHPGV HCCCCCEEEEECCCC	13.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RDH12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RDH12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RDH12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AGFG1_HUMAN	AGFG1	physical	26186194
UBE2T_HUMAN	UBE2T	physical	26186194
RN123_HUMAN	RNF123	physical	26186194
CCD25_HUMAN	CCDC25	physical	26186194
UB2D2_HUMAN	UBE2D2	physical	26186194
ARCH_HUMAN	ZBTB8OS	physical	26186194
UB2E3_HUMAN	UBE2E3	physical	26186194
LASP1_HUMAN	LASP1	physical	26186194
ARPIN_HUMAN	ARPIN	physical	26186194
ARFG1_HUMAN	ARFGAP1	physical	26186194
TKFC_HUMAN	DAK	physical	26186194
UBAC1_HUMAN	UBAC1	physical	26186194
TKFC_HUMAN	DAK	physical	28514442
LASP1_HUMAN	LASP1	physical	28514442
4EBP2_HUMAN	EIF4EBP2	physical	28514442
UB2E3_HUMAN	UBE2E3	physical	28514442
ARPIN_HUMAN	ARPIN	physical	28514442
STABP_HUMAN	STAMBP	physical	28514442
RN123_HUMAN	RNF123	physical	28514442
TES_HUMAN	TES	physical	28514442
PMVK_HUMAN	PMVK	physical	28514442
CGL_HUMAN	CTH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 612712: Leber congenital amaurosis 13 (LCA13)
• 612712: Retinitis pigmentosa 53 (RP53)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00162: Vitamin A