ARCH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARCH_HUMAN
• UniProt AC: Q8IWT0
• Protein Name: Protein archease
• Gene Name: ZBTB8OS
• Organism: Homo sapiens (Human).
• Sequence Length: 167
• Protein Description: Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation..
• Protein Sequence: MAQEEEDVRDYNLTEEQKAIKAKYPPVNRKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFFIPREVKVLSIDQRNFKLRSIGWGEEFSLSKHPQGTEVKAITYSAMQVYNEENPEVFVIIDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQEEEDVR ------CCCCHHHHH	26.03	19413330
18	Ubiquitination	YNLTEEQKAIKAKYP CCCCHHHHHHHCCCC	56.19	-
23	Ubiquitination	EQKAIKAKYPPVNRK HHHHHHCCCCCCCCC	53.97	-
30	Ubiquitination	KYPPVNRKYEYLDHT CCCCCCCCEEECCCC	36.91	-
35	Ubiquitination	NRKYEYLDHTADVQL CCCEEECCCCCCEEE	35.87	-
112	Ubiquitination	FFIPREVKVLSIDQR CCCCCEEEEEEECCC	32.48	21890473
124	Ubiquitination	DQRNFKLRSIGWGEE CCCCEEEEECCCCCC	27.15	-
124 (in isoform 1)	Ubiquitination	-	27.15	21890473
148	Ubiquitination	TEVKAITYSAMQVYN CCEEEEEEEEEEHHC	6.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARCH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARCH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARCH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT8A2_HUMAN	ATP8A2	physical	26344197
ENPL_HUMAN	HSP90B1	physical	26344197
PR40A_HUMAN	PRPF40A	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330