AT8A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT8A2_HUMAN
• UniProt AC: Q9NTI2
• Protein Name: Phospholipid-transporting ATPase IB
• Gene Name: ATP8A2
• Organism: Homo sapiens (Human).
• Sequence Length: 1148
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Golgi apparatus . Endosome. Cell projection, cilium, photoreceptor outer segment. Cell membrane . Localizes to the Golgi and endosomes in photoreceptor cells. Localizes to disk membranes of rod photoreceptor o
• Protein Description: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival..
• Protein Sequence: MSRATSVGDQLEAPARTIYLNQPHLNKFRDNQISTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHKADNAVNKKKTIVLRNGMWHTIMWKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMCYVETANLDGETNLKIRQGLSHTADMQTREVLMKLSGTIECEGPNRHLYDFTGNLNLDGKSLVALGPDQILLRGTQLRNTQWVFGIVVYTGHDTKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSAGALYWNRSHGEKNWYIKKMDTTSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDTDMYYIGNDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNIMNFKKCSIAGVTYGHFPELAREPSSDDFCRMPPPCSDSCDFDDPRLLKNIEDRHPTAPCIQEFLTLLAVCHTVVPEKDGDNIIYQASSPDEAALVKGAKKLGFVFTARTPFSVIIEAMGQEQTFGILNVLEFSSDRKRMSVIVRTPSGRLRLYCKGADNVIFERLSKDSKYMEETLCHLEYFATEGLRTLCVAYADLSENEYEEWLKVYQEASTILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTDLGNLLGKENDVALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEEHGAVSQEEVIRAYDTTKKKSRKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRATSVGD ------CCCCCCHHH	41.76	20363803
5	Phosphorylation	---MSRATSVGDQLE ---CCCCCCHHHHCC	23.88	20363803
6	Phosphorylation	--MSRATSVGDQLEA --CCCCCCHHHHCCC	24.10	20363803
23	Phosphorylation	RTIYLNQPHLNKFRD EEEEECCHHHHHCCC	32.62	24719451
24	Phosphorylation	TIYLNQPHLNKFRDN EEEECCHHHHHCCCC	32.07	24719451
30	Phosphorylation	PHLNKFRDNQISTAK HHHHHCCCCCCCHHH	55.29	24719451
34	Phosphorylation	KFRDNQISTAKYSVL HCCCCCCCHHHHHHH	16.73	-
45	Phosphorylation	YSVLTFLPRFLYEQI HHHHHHHHHHHHHHH	22.30	-
46	Phosphorylation	SVLTFLPRFLYEQIR HHHHHHHHHHHHHHH	36.03	19664994
112	Acetylation	ADNAVNKKKTIVLRN CCCCCCCCCEEEEEC	50.36	20167786
128	Acetylation	MWHTIMWKEVAVGDI CEEEEEEEEEECCCE	25.57	20167786
239	Phosphorylation	RGTQLRNTQWVFGIV ECCCCCCCCEEEEEE	19.85	-
248	Phosphorylation	WVFGIVVYTGHDTKL EEEEEEEEECCCHHH	8.98	-
249	Phosphorylation	VFGIVVYTGHDTKLM EEEEEEEECCCHHHC	19.21	-
253	Phosphorylation	VVYTGHDTKLMQNST EEEECCCHHHCCCCC	22.02	-
259	Phosphorylation	DTKLMQNSTKAPLKR CHHHCCCCCCCCCCC	17.88	-
260	Phosphorylation	TKLMQNSTKAPLKRS HHHCCCCCCCCCCCC	38.48	-
267	Phosphorylation	TKAPLKRSNVEKVTN CCCCCCCCCCCCCHH	43.57	-
372	Phosphorylation	DTPAMARTSNLNEEL CCHHHHHCCCCCHHH	16.66	-
373	Phosphorylation	TPAMARTSNLNEELG CHHHHHCCCCCHHHC	33.49	23898821
383	Ubiquitination	NEELGQVKYLFSDKT CHHHCCCEEEEECCC	28.48	-
384	Phosphorylation	EELGQVKYLFSDKTG HHHCCCEEEEECCCC	17.70	23898821
387	Phosphorylation	GQVKYLFSDKTGTLT CCCEEEEECCCCEEE	35.29	23898821
390	Phosphorylation	KYLFSDKTGTLTCNI EEEEECCCCEEEEEE	40.15	22210691
404	Phosphorylation	IMNFKKCSIAGVTYG EECCCCCEEEEEEEC	25.09	-
409	Phosphorylation	KCSIAGVTYGHFPEL CCEEEEEEECCCHHH	23.91	-
410	Phosphorylation	CSIAGVTYGHFPELA CEEEEEEECCCHHHC	13.24	-
421	Phosphorylation	PELAREPSSDDFCRM HHHCCCCCCCCCCCC	41.46	29691806
422	Phosphorylation	ELAREPSSDDFCRMP HHCCCCCCCCCCCCC	52.49	29691806
453	Phosphorylation	NIEDRHPTAPCIQEF CCHHHCCCCHHHHHH	36.79	-
506	Phosphorylation	GFVFTARTPFSVIIE CEEEEECCCCCHHHH	26.65	-
509	Phosphorylation	FTARTPFSVIIEAMG EEECCCCCHHHHHCC	17.38	-
563	Phosphorylation	NVIFERLSKDSKYME CEEEEECCCCCHHHH	40.41	20068231
566	Phosphorylation	FERLSKDSKYMEETL EEECCCCCHHHHHHH	29.44	20068231
603	Phosphorylation	ENEYEEWLKVYQEAS CCHHHHHHHHHHHHH	2.80	20068231
606	Phosphorylation	YEEWLKVYQEASTIL HHHHHHHHHHHHHHH	10.07	20068231
650	Phosphorylation	LQAGVPETIATLLKA HHCCCCHHHHHHHHH	15.16	-
695	Phosphorylation	LILLKEDSLDATRAA EEEEECCCCHHHHHH	29.28	-
762	Phosphorylation	RVSPLQKSEIVDVVK CCCCCCCCHHHHHHH	21.42	27794612
1005	Phosphorylation	WLVFFGIYSTIWPTI HHHHHHHHHHHCCCC	10.51	24248375
1006	Phosphorylation	LVFFGIYSTIWPTIP HHHHHHHHHHCCCCC	16.11	24248375
1101	Phosphorylation	IKRLGRKTPPTLFRG HHHHCCCCCCCCCCC	32.89	29691806
1104	Phosphorylation	LGRKTPPTLFRGSSL HCCCCCCCCCCCCCC	39.47	29691806
1109	Phosphorylation	PPTLFRGSSLQQGVP CCCCCCCCCCCCCCC	24.50	22210691
1110	Phosphorylation	PTLFRGSSLQQGVPH CCCCCCCCCCCCCCC	32.78	22210691
1119	Phosphorylation	QQGVPHGYAFSQEEH CCCCCCCCCCCHHHC	11.05	22210691
1130	Phosphorylation	QEEHGAVSQEEVIRA HHHCCCCCHHHHHHH	31.19	22210691
1138	Phosphorylation	QEEVIRAYDTTKKKS HHHHHHHHHCCCCCC	12.18	20860994
1141	Phosphorylation	VIRAYDTTKKKSRKK HHHHHHCCCCCCCCC	37.66	20860994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT8A2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT8A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT8A2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UIMC1_HUMAN	UIMC1	physical	17621610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.