TPC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPC2_HUMAN
• UniProt AC: Q8NHX9
• Protein Name: Two pore calcium channel protein 2
• Gene Name: TPCN2
• Organism: Homo sapiens (Human).
• Sequence Length: 752
• Subcellular Localization: Lysosome membrane; Multi-pass membrane protein. Only the acidic lysosomal fraction is sensitive to NAADP..
• Protein Description: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction..
• Protein Sequence: MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWLCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	GDWPAGLTTYRSIQV CCCCCCCCEEEEEEC	22.36	-
28	Phosphorylation	DWPAGLTTYRSIQVG CCCCCCCEEEEEECC	23.21	-
29	Phosphorylation	WPAGLTTYRSIQVGP CCCCCCEEEEEECCC	9.34	-
31	Phosphorylation	AGLTTYRSIQVGPGA CCCCEEEEEECCCCH	13.63	28555341
326	Phosphorylation	LMKSLQTSLFRRRLG HHHHHHHHHHHHHHH	16.73	24719451
376	Acetylation	VQLDSSHKQAMMEKV HCCCCHHHHHHHHHH	41.52	7683799
376	Ubiquitination	VQLDSSHKQAMMEKV HCCCCHHHHHHHHHH	41.52	-
398	Ubiquitination	LSAEEFQKLFNELDR HCHHHHHHHHHHHHH	61.44	-
498	Phosphorylation	LGLRGYLSYPSNVFD HHHHCHHCCCCCHHH	26.89	-
539	Phosphorylation	PEMVGLLSLWDMTRM HHHHHHHHHHHHHHH	32.24	28258704
571	Phosphorylation	LMAVVASTVLGLVQN HHHHHHHHHHHHHHH	15.26	-
611	N-linked_Glycosylation	VIVALPGNSSLAPAN EEEECCCCCCCCCCC	26.87	UniProtKB CARBOHYD
618	N-linked_Glycosylation	NSSLAPANGSAPCGS CCCCCCCCCCCCCCC	43.84	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
376	Acetylation	376 (0)	K ⇒ R	rs3750965	Hair color	20585627

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANR27_HUMAN	ANKRD27	physical	28514442
CBPC5_HUMAN	AGBL5	physical	28514442
UBP32_HUMAN	USP32	physical	28514442
DEN6A_HUMAN	DENND6A	physical	28514442
TPPC8_HUMAN	TRAPPC8	physical	28514442
WDR44_HUMAN	WDR44	physical	28514442
CLCN3_HUMAN	CLCN3	physical	28514442
FBX10_HUMAN	FBXO10	physical	28514442
ARRB2_HUMAN	ARRB2	physical	28514442
RRAGB_HUMAN	RRAGB	physical	28514442
P4K2A_HUMAN	PI4K2A	physical	28514442
TR19L_HUMAN	RELT	physical	28514442
AP3B1_HUMAN	AP3B1	physical	28514442
WDR11_HUMAN	WDR11	physical	28514442
TSR3_HUMAN	TSR3	physical	28514442
PCDH9_HUMAN	PCDH9	physical	28514442
DIP2A_HUMAN	DIP2A	physical	28514442
RAB6B_HUMAN	RAB6B	physical	28514442
ZRAB3_HUMAN	ZRANB3	physical	28514442
AP3D1_HUMAN	AP3D1	physical	28514442
CD320_HUMAN	CD320	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
CERK1_HUMAN	CERK	physical	28514442
OCRL_HUMAN	OCRL	physical	28514442
AP3S1_HUMAN	AP3S1	physical	28514442
DP13A_HUMAN	APPL1	physical	28514442
HXK3_HUMAN	HK3	physical	28514442
MP2K7_HUMAN	MAP2K7	physical	28514442
DGLB_HUMAN	DAGLB	physical	28514442
B4GT5_HUMAN	B4GALT5	physical	28514442
TMM56_HUMAN	TMEM56	physical	28514442
RN149_HUMAN	RNF149	physical	28514442
LRP10_HUMAN	LRP10	physical	28514442
VAMP2_HUMAN	VAMP2	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
SNX17_HUMAN	SNX17	physical	28514442
PTPRD_HUMAN	PTPRD	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
STX6_HUMAN	STX6	physical	28514442
TPPC5_HUMAN	TRAPPC5	physical	28514442
EHD4_HUMAN	EHD4	physical	28514442
KC1G3_HUMAN	CSNK1G3	physical	28514442
NFIP1_HUMAN	NDFIP1	physical	28514442
FGFR1_HUMAN	FGFR1	physical	28514442
NOMO3_HUMAN	NOMO3	physical	28514442
UXS1_HUMAN	UXS1	physical	28514442
EBP_HUMAN	EBP	physical	28514442
ZDH18_HUMAN	ZDHHC18	physical	28514442
NOMO1_HUMAN	NOMO1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.