PDCD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDCD1_HUMAN
• UniProt AC: Q15116
• Protein Name: Programmed cell death protein 1
• Gene Name: PDCD1
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors..
• Protein Sequence: MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	N-linked_Glycosylation	LVVTEGDNATFTCSF EEEECCCCEEEEEEE	52.30	28165004
58	N-linked_Glycosylation	TFTCSFSNTSESFVL EEEEEECCCCCEEEE	45.68	28165004
74	N-linked_Glycosylation	WYRMSPSNQTDKLAA EEECCCCCCCCCEEC	52.75	28165004
116	N-linked_Glycosylation	SVVRARRNDSGTYLC EEEEEEECCCCCEEE	42.10	28165004
118	Phosphorylation	VRARRNDSGTYLCGA EEEEECCCCCEEEEE	36.26	25278378
120	Phosphorylation	ARRNDSGTYLCGAIS EEECCCCCEEEEEEE	19.78	25278378
121	Phosphorylation	RRNDSGTYLCGAISL EECCCCCEEEEEEEE	11.97	25278378
127	Phosphorylation	TYLCGAISLAPKAQI CEEEEEEEECCHHHH	20.25	25278378
159	Phosphorylation	PTAHPSPSPRPAGQF CCCCCCCCCCCCCCC	37.57	17081983
223	Phosphorylation	VPVFSVDYGELDFQW CCEEEEECCCCCEEE	15.45	-
248	Phosphorylation	CVPEQTEYATIVFPS CCCCCCCEEEEECCC	16.66	-
255	Phosphorylation	YATIVFPSGMGTSSP EEEEECCCCCCCCCC	29.91	28348404
259	Phosphorylation	VFPSGMGTSSPARRG ECCCCCCCCCCCCCC	19.69	28348404
260	Phosphorylation	FPSGMGTSSPARRGS CCCCCCCCCCCCCCC	28.70	28348404
261	Phosphorylation	PSGMGTSSPARRGSA CCCCCCCCCCCCCCC	23.55	28348404
285	Phosphorylation	RPEDGHCSWPL---- CCCCCCCCCCC----	26.50	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDCD1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
58	N	Glycosylation	N-glycosylation at Asn-58 contains at least two N-acetylglucosamine units and one fucose.	28165004
233	K	ubiquitylation	Ubiquitinated at Lys-233 by the SCF(FBXO38) complex, leading to its proteasomal degradation.	30487606

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDCD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PD1L2_HUMAN	PDCD1LG2	physical	12893276
SOCS1_HUMAN	SOCS1	physical	21263070
PD1L2_MOUSE	Pdcd1lg2	physical	11224527
PD1L1_HUMAN	CD274	physical	21982860
CT024_HUMAN	C20orf24	physical	28514442
POP5_HUMAN	POP5	physical	28514442
SFXN3_HUMAN	SFXN3	physical	28514442
SCMC3_HUMAN	SLC25A23	physical	28514442
DGLB_HUMAN	DAGLB	physical	28514442
EMRE_HUMAN	SMDT1	physical	28514442
RHDF2_HUMAN	RHBDF2	physical	28514442
DEN6A_HUMAN	DENND6A	physical	28514442
MFRN2_HUMAN	SLC25A28	physical	28514442
INT4_HUMAN	INTS4	physical	28514442
ABD18_HUMAN	C4orf29	physical	28514442
RTL8C_HUMAN	FAM127A	physical	28514442
INT7_HUMAN	INTS7	physical	28514442
GDC_HUMAN	SLC25A16	physical	28514442
DCP2_HUMAN	DCP2	physical	28514442
PLPL6_HUMAN	PNPLA6	physical	28514442
WDFY3_HUMAN	WDFY3	physical	28514442
DAD1_HUMAN	DAD1	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442
S2546_HUMAN	SLC25A46	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
FAM3C_HUMAN	FAM3C	physical	28514442
TM223_HUMAN	TMEM223	physical	28514442
XPR1_HUMAN	XPR1	physical	28514442
SH3B4_HUMAN	SH3BP4	physical	28514442
NAV1_HUMAN	NAV1	physical	28514442
PTN9_HUMAN	PTPN9	physical	28514442
ARF6_HUMAN	ARF6	physical	28514442
PTN11_HUMAN	PTPN11	physical	28514442
ORNT1_HUMAN	SLC25A15	physical	28514442
SPPL3_HUMAN	SPPL3	physical	28514442
GLT11_HUMAN	GALNT11	physical	28514442
ADT3_HUMAN	SLC25A6	physical	28514442
CHPT1_HUMAN	CHPT1	physical	28514442
RPTOR_HUMAN	RPTOR	physical	28514442
GCP4_HUMAN	TUBGCP4	physical	28514442
ARL5B_HUMAN	ARL5B	physical	28514442
GLPK_HUMAN	GK	physical	28514442
T126B_HUMAN	TMEM126B	physical	28514442
MCU_HUMAN	MCU	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442
BIG2_HUMAN	ARFGEF2	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
HEAT6_HUMAN	HEATR6	physical	28514442
LGR4_HUMAN	LGR4	physical	28514442
S26A6_HUMAN	SLC26A6	physical	28514442
RTEL1_HUMAN	RTEL1	physical	28514442
T184B_HUMAN	TMEM184B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.