| UniProt ID | PD1L2_HUMAN | |
|---|---|---|
| UniProt AC | Q9BQ51 | |
| Protein Name | Programmed cell death 1 ligand 2 | |
| Gene Name | PDCD1LG2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 273 | |
| Subcellular Localization |
Isoform 3: Secreted . Isoform 2: Endomembrane system Single-pass type I membrane protein . Isoform 1: Cell membrane Single-pass type I membrane protein . |
|
| Protein Description | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).. | |
| Protein Sequence | MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPTWLLHIFIPFCIIAFIFIATVIALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | IFLLLMLSLELQLHQ HHHHHHHHHHHHHHH | 13.06 | 24719451 | |
| 22 | Phosphorylation | HQIAALFTVTVPKEL HHHHHHHEEEECCEE | 19.00 | 24719451 | |
| 37 | N-linked_Glycosylation | YIIEHGSNVTLECNF EEEECCCCEEEEEEC | 35.07 | UniProtKB CARBOHYD | |
| 64 | N-linked_Glycosylation | ASLQKVENDTSPHRE EEEHHHHCCCCCHHH | 61.93 | UniProtKB CARBOHYD | |
| 114 | Phosphorylation | GVAWDYKYLTLKVKA EEEECCEEEEEEEHE | 9.93 | - | |
| 116 | Phosphorylation | AWDYKYLTLKVKASY EECCEEEEEEEHEEE | 22.80 | - | |
| 128 | Phosphorylation | ASYRKINTHILKVPE EEEEECEEEEEECCC | 17.48 | - | |
| 157 | N-linked_Glycosylation | LAEVSWPNVSVPANT EEEEECCCEECCCCC | 32.22 | UniProtKB CARBOHYD | |
| 159 | Phosphorylation | EVSWPNVSVPANTSH EEECCCEECCCCCCC | 29.08 | - | |
| 163 | N-linked_Glycosylation | PNVSVPANTSHSRTP CCEECCCCCCCCCCC | 35.72 | UniProtKB CARBOHYD | |
| 165 | Phosphorylation | VSVPANTSHSRTPEG EECCCCCCCCCCCCC | 21.19 | - | |
| 167 | Phosphorylation | VPANTSHSRTPEGLY CCCCCCCCCCCCCEE | 37.30 | - | |
| 169 | Phosphorylation | ANTSHSRTPEGLYQV CCCCCCCCCCCEEEE | 28.80 | 29978859 | |
| 174 | Phosphorylation | SRTPEGLYQVTSVLR CCCCCCEEEEEEEEE | 16.28 | 29978859 | |
| 177 | Phosphorylation | PEGLYQVTSVLRLKP CCCEEEEEEEEEECC | 9.52 | 29978859 | |
| 178 | Phosphorylation | EGLYQVTSVLRLKPP CCEEEEEEEEEECCC | 21.94 | 29978859 | |
| 189 | N-linked_Glycosylation | LKPPPGRNFSCVFWN ECCCCCCCEEEEEEC | 38.81 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PD1L2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PD1L2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PD1L2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PD1L2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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