MAS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAS_HUMAN
• UniProt AC: P04201
• Protein Name: Proto-oncogene Mas
• Gene Name: MAS1
• Organism: Homo sapiens (Human).
• Sequence Length: 325
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1..
• Protein Sequence: MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	N-linked_Glycosylation	---MDGSNVTSFVVE ---CCCCCCEEEEEE	46.76	UniProtKB CARBOHYD
16	N-linked_Glycosylation	FVVEEPTNISTGRNA EEEECCCCCCCCCCC	36.61	UniProtKB CARBOHYD
22	N-linked_Glycosylation	TNISTGRNASVGNAH CCCCCCCCCCCCCCC	37.60	UniProtKB CARBOHYD
121	Phosphorylation	FGYNTGLYLLTAISV ECCCHHHHHHHHHCH	10.87	-
133	Phosphorylation	ISVERCLSVLYPIWY HCHHHHHHHHHHHHH	17.44	29083192
136	Phosphorylation	ERCLSVLYPIWYRCH HHHHHHHHHHHHHCC	7.19	29083192
140	Phosphorylation	SVLYPIWYRCHRPKY HHHHHHHHHCCCCHH	12.23	29083192
227	Phosphorylation	ASHSSKLYIVIMVTI CCCCCHHHHHHHHHH	9.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTR1L_HUMAN	GPR50	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
EFHD1_HUMAN	EFHD1	physical	28514442
ABCD1_HUMAN	ABCD1	physical	28514442
SPG7_HUMAN	SPG7	physical	28514442
TR19L_HUMAN	RELT	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
S35G2_HUMAN	SLC35G2	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
ZYX_HUMAN	ZYX	physical	28514442
TMM11_HUMAN	TMEM11	physical	28514442
AVR2B_HUMAN	ACVR2B	physical	28514442
ACD10_HUMAN	ACAD10	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442
AB17B_HUMAN	ABHD17B	physical	28514442
IPRI_HUMAN	ITPRIP	physical	28514442
ZNT5_HUMAN	SLC30A5	physical	28514442
CRYAB_HUMAN	CRYAB	physical	28514442
PDS5A_HUMAN	PDS5A	physical	28514442
SFXN5_HUMAN	SFXN5	physical	28514442
MET15_HUMAN	METTL15	physical	28514442
RAB3B_HUMAN	RAB3B	physical	28514442
ARL10_HUMAN	ARL10	physical	28514442
S4A7_HUMAN	SLC4A7	physical	28514442
ZFPL1_HUMAN	ZFPL1	physical	28514442
VGFR3_HUMAN	FLT4	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
GCP2_HUMAN	TUBGCP2	physical	28514442
CND3_HUMAN	NCAPG	physical	28514442
ATLA2_HUMAN	ATL2	physical	28514442
GCN1_HUMAN	GCN1L1	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
ARL8B_HUMAN	ARL8B	physical	28514442
PKN3_HUMAN	PKN3	physical	28514442
INT12_HUMAN	INTS12	physical	28514442
ABHD3_HUMAN	ABHD3	physical	28514442
VATH_HUMAN	ATP6V1H	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
SYEM_HUMAN	EARS2	physical	28514442
BTAF1_HUMAN	BTAF1	physical	28514442
RETR3_HUMAN	FAM134C	physical	28514442
FAKD1_HUMAN	FASTKD1	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442
TTK_HUMAN	TTK	physical	28514442
ATM_HUMAN	ATM	physical	28514442
ECM29_HUMAN	KIAA0368	physical	28514442
PDS5B_HUMAN	PDS5B	physical	28514442
AT133_HUMAN	ATP13A3	physical	28514442
KIRR1_HUMAN	KIRREL	physical	28514442
EPHA2_HUMAN	EPHA2	physical	28514442
CJ035_HUMAN	C10orf35	physical	28514442
APRV1_HUMAN	ASPRV1	physical	28514442
JAK1_HUMAN	JAK1	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
VMP1_HUMAN	VMP1	physical	28514442
ERBB2_HUMAN	ERBB2	physical	28514442
IDHP_HUMAN	IDH2	physical	28514442
SGPP1_HUMAN	SGPP1	physical	28514442
CND1_HUMAN	NCAPD2	physical	28514442
ATAD1_HUMAN	ATAD1	physical	28514442
TYK2_HUMAN	TYK2	physical	28514442
GPHRA_HUMAN	GPR89B	physical	28514442
GPHRB_HUMAN	GPR89B	physical	28514442
YLAT2_HUMAN	SLC7A6	physical	28514442
TBRG4_HUMAN	TBRG4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.