YLAT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YLAT2_HUMAN
• UniProt AC: Q92536
• Protein Name: Y+L amino acid transporter 2
• Gene Name: SLC7A6 {ECO:0000312|HGNC:HGNC:11064}
• Organism: Homo sapiens (Human).
• Sequence Length: 515
• Subcellular Localization: Basolateral cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells..
• Protein Sequence: MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	AREPGRPTPTYHLVP CCCCCCCCCCEEECC	27.23	21945579
12	Phosphorylation	EPGRPTPTYHLVPNT CCCCCCCCEEECCCC	26.50	21945579
13	Phosphorylation	PGRPTPTYHLVPNTS CCCCCCCEEECCCCC	8.38	21945579
19	Phosphorylation	TYHLVPNTSQSQVEE CEEECCCCCHHHCCC	23.29	21945579
20	Phosphorylation	YHLVPNTSQSQVEED EEECCCCCHHHCCCC	34.18	21945579
22	Phosphorylation	LVPNTSQSQVEEDVS ECCCCCHHHCCCCCC	35.64	21945579
29	Phosphorylation	SQVEEDVSSPPQRSS HHCCCCCCCCCCCCH	49.83	21945579
30	Phosphorylation	QVEEDVSSPPQRSSE HCCCCCCCCCCCCHH	40.21	21945579
35	Phosphorylation	VSSPPQRSSETMQLK CCCCCCCCHHHHHHH	27.55	29978859
36	Phosphorylation	SSPPQRSSETMQLKK CCCCCCCHHHHHHHH	39.00	23312004
38	Phosphorylation	PPQRSSETMQLKKEI CCCCCHHHHHHHHHH	16.50	29978859
42	Ubiquitination	SSETMQLKKEISLLN CHHHHHHHHHHHHHC	31.31	-
131	Phosphorylation	AFIRLWVSLLVVEPT HHHHHHHHHHCCCCC	12.38	-
347	Phosphorylation	SRLFFVGSREGHLPD CCEEECCCCCCCHHH	23.12	21712546
488	Phosphorylation	RNVLAAITRGTQQLC HHHHHHHHHHHHHHH	20.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YLAT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YLAT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YLAT2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of YLAT2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.