LBN_HUMAN - dbPTM
LBN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LBN_HUMAN
UniProt AC Q86UK5
Protein Name Limbin
Gene Name EVC2
Organism Homo sapiens (Human).
Sequence Length 1308
Subcellular Localization Cell membrane
Single-pass type I membrane protein . Cytoplasm, cytoskeleton, cilium basal body . Cell projection, cilium . Cell projection, cilium membrane . Nucleus . The EvC complex localizes at the base of cilia in the EvC zone of primary cilia
Protein Description Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis..
Protein Sequence MDPSGSRGRPTWVLAGGLLAVALALGGRGCLGASSRPRWRPLGAQPPRDPQVAPRSGPGLRIPPGRSGAGPESSTQDLPCMIWPKVECCHFKTAVEAPLGMKLDKKMEVFIPLSTSAASSGPWAHSLFAFIPSWPKKNLFKRESPITHRLYGDISREVQGTSENGVIFQKCALVSGSSEAQTARIWLLVNNTKTTSSANLSELLLLDSIAGLTIWDSVGNRTSEGFQAFSKKFLQVGDAFAVSYAATLQAGDLGNGESLKLPAQLTFQSSSRNRTQLKVLFSITAEENVTVLPHHGLHAAGFFIAFLLSLVLTWAALFLMVRYQCLKGNMLTRHRVWQYESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEIATLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEIQEEYDRKMVALTAECDLETRKKMENQYQREMMAMEEAEELLKRAGERSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQIKSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQKHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDLKQEKKKLHQKLITKRRRELLQKHREQRREQASVGEAFRTVEDAGQYLHQKRSLMEEHGATLEELQERLDQAALDDLRTLTLSLFEKATDELRRLQNSAMTQELLKRGVPWLFLQQILEEHGKEMAARAEQLEGEERDRDQEGVQSVRQRLKDDAPEAVTEEQAELRRWEHLIFMKLCSSVFSLSEEELLRMRQEVHGCFAQMDRSLALPKIRARVLLQQFQTAWREAEFVKLDQAVAAPELQQQSKVRKSRSKSKSKGELLKKCIEDKIHLCEEQASEDLVEKVRGELLRERVQRMEAQEGGFAQSLVALQFQKASRVTETLSAYTALLSIQDLLLEELSASEMLTKSACTQILESHSRELQELERKLEDQLVQQEAAQQQQALASWQQWVADGPGILNEPGEVDSERQVSTVLHQALSKSQTLLEQHQQCLREEQQNSVVLEDLLENMEADTFATLCSQELRLASYLARMAMVPGATLRRLLSVVLPTASQPQLLALLDSATERHVDHAAESDGGAEQADVGRRRKHQSWWQALDGKLRGDLISRGLEKMLWARKRKQSILKKTCLPLRERMIFSGKGSWPHLSLEPIGELAPVPIVGAETIDLLNTGEKLFIFRNPKEPEISLHVPPRKKKNFLNAKKAMRALGMD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MDPSGSRGRPT
----CCCCCCCCCCE		62.8324043423
6Phosphorylation--MDPSGSRGRPTWV
--CCCCCCCCCCEEC		35.5824043423
11PhosphorylationSGSRGRPTWVLAGGL
CCCCCCCEECHHHHH		27.1824043423
93PhosphorylationVECCHFKTAVEAPLG
CCCCCCCCCCCCCCC		34.68-
220N-linked_GlycosylationTIWDSVGNRTSEGFQ
EEECCCCCCCCHHHH		41.73UniProtKB CARBOHYD
339PhosphorylationTRHRVWQYESKLEPL
HHHHEEEEECCCCCC		13.3728152594
341PhosphorylationHRVWQYESKLEPLPF
HHEEEEECCCCCCCC		37.2928152594
415PhosphorylationALLLKNLTSSGHLSP
HHHHHHCCCCCCCCH		30.1823911959
416PhosphorylationLLLKNLTSSGHLSPQ
HHHHHCCCCCCCCHH		37.1723911959
417PhosphorylationLLKNLTSSGHLSPQV
HHHHCCCCCCCCHHH		25.6223911959
429PhosphorylationPQVERKMSAVFKKQF
HHHHHHHHHHHHHHH		25.0627251275
455PhosphorylationDRKMVALTAECDLET
HHHHHHHHHHCCHHH		15.63-
547PhosphorylationIFFTQIKSAIFKGEL
HHHHHHHHHHHCCCC		28.3827251275
905PhosphorylationAPELQQQSKVRKSRS
CHHHHHHHHHHHHHH		28.87-
910PhosphorylationQQSKVRKSRSKSKSK
HHHHHHHHHHCCCCH		31.08-
912PhosphorylationSKVRKSRSKSKSKGE
HHHHHHHHCCCCHHH		48.66-
1008PhosphorylationASEMLTKSACTQILE
CCHHHCHHHHHHHHH		24.28-
1011PhosphorylationMLTKSACTQILESHS
HHCHHHHHHHHHHHH		20.54-
1220PhosphorylationWARKRKQSILKKTCL
HHHHHHHHHHHHHCC		32.6824719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LBN_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LBN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LBN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCP60_HUMANACBD3physical
26638075
ACSL3_HUMANACSL3physical
26638075
SAHH_HUMANAHCYphysical
26638075
AL3A2_HUMANALDH3A2physical
26638075
ANKL2_HUMANANKLE2physical
26638075
VAS1_HUMANATP6AP1physical
26638075
RENR_HUMANATP6AP2physical
26638075
BAG2_HUMANBAG2physical
26638075
BAP31_HUMANBCAP31physical
26638075
THEM6_HUMANTHEM6physical
26638075
CAMLG_HUMANCAMLGphysical
26638075
CCD47_HUMANCCDC47physical
26638075
CDKAL_HUMANCDKAL1physical
26638075
CKAP4_HUMANCKAP4physical
26638075
DDRGK_HUMANDDRGK1physical
26638075
DHRS7_HUMANDHRS7physical
26638075
EMD_HUMANEMDphysical
26638075
ESYT1_HUMANESYT1physical
26638075
FND3A_HUMANFNDC3Aphysical
26638075
GLMN_HUMANGLMNphysical
26638075
HMOX2_HUMANHMOX2physical
26638075
JPH1_HUMANJPH1physical
26638075
LBR_HUMANLBRphysical
26638075
MAGT1_HUMANMAGT1physical
26638075
MLXPL_HUMANMLXIPLphysical
26638075
MOGS_HUMANMOGSphysical
26638075
NSDHL_HUMANNSDHLphysical
26638075
NUDC_HUMANNUDCphysical
26638075
NUDC2_HUMANNUDCD2physical
26638075
NUDC3_HUMANNUDCD3physical
26638075
PGRC2_HUMANPGRMC2physical
26638075
PLD3_HUMANPLD3physical
26638075
NCPR_HUMANPORphysical
26638075
PREB_HUMANPREBphysical
26638075
RABL3_HUMANRABL3physical
26638075
RPN1_HUMANRPN1physical
26638075
SCFD1_HUMANSCFD1physical
26638075
SC11A_HUMANSEC11Aphysical
26638075
SC24B_HUMANSEC24Bphysical
26638075
SEC63_HUMANSEC63physical
26638075
ACATN_HUMANSLC33A1physical
26638075
NSMA3_HUMANSMPD4physical
26638075
SOAT1_HUMANSOAT1physical
26638075
SPCS2_HUMANSPCS2physical
26638075
SPCS3_HUMANSPCS3physical
26638075
SRPRA_HUMANSRPRphysical
26638075
SRPRB_HUMANSRPRBphysical
26638075
STIM1_HUMANSTIM1physical
26638075
STT3B_HUMANSTT3Bphysical
26638075
STX5_HUMANSTX5physical
26638075
TM199_HUMANTMEM199physical
26638075
MACOI_HUMANTMEM57physical
26638075
TMX1_HUMANTMX1physical
26638075
TOIP1_HUMANTOR1AIP1physical
26638075
TRI13_HUMANTRIM13physical
26638075
EMC2_HUMANEMC2physical
26638075
UBXN4_HUMANUBXN4physical
26638075
VANG1_HUMANVANGL1physical
26638075
VEZA_HUMANVEZTphysical
26638075
VMA21_HUMANVMA21physical
26638075
VRK2_HUMANVRK2physical
26638075
ARP2_HUMANACTR2physical
26638075
CDC37_HUMANCDC37physical
26638075
CLCC1_HUMANCLCC1physical
26638075
CP51A_HUMANCYP51A1physical
26638075
DNJC7_HUMANDNAJC7physical
26638075
FKBP8_HUMANFKBP8physical
26638075
GRM5_HUMANGRM5physical
26638075
GYS1_HUMANGYS1physical
26638075
HPBP1_HUMANHSPBP1physical
26638075
ISOC1_HUMANISOC1physical
26638075
LMBRL_HUMANLMBR1Lphysical
26638075
NU155_HUMANNUP155physical
26638075
PTN1_HUMANPTPN1physical
26638075
ST7_HUMANST7physical
26638075
STIP1_HUMANSTIP1physical
26638075
CHIP_HUMANSTUB1physical
26638075
SGT1_HUMANSUGT1physical
26638075
NDC1_HUMANNDC1physical
26638075
TTC1_HUMANTTC1physical
26638075
UB2J1_HUMANUBE2J1physical
26638075
UN45A_HUMANUNC45Aphysical
26638075
1433F_HUMANYWHAHphysical
26638075
Drug and Disease Associations
Kegg Disease
H00503 EVC-related disorders, including: Ellis-van Creveld syndrome; Weyers acrodental dysostosis
OMIM Disease
225500Ellis-van Creveld syndrome (EVC)
193530Acrofacial dysostosis, Weyers type (WAD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LBN_HUMAN

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Related Literatures of Post-Translational Modification

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