RGS1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS1_ARATH
• UniProt AC: Q8H1F2
• Protein Name: Regulator of G-protein signaling 1
• Gene Name: RGS1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 459
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . accumulates at the nascent cell plate during cytokinesis.
• Protein Description: Glucose-regulated GTPase-accelerating protein (GAP) for the GTP-bound self-activating heterotrimeric G alpha protein GPA1. Cooperates with G beta-gamma dimers to maintain an unactivated but fully functional pool of GPA1. Phosphorylation-dependent endocytosis of RGS1 physically uncouples the two proteins, resulting in signal activation. Free AGB1 is essential, but not sufficient, for RGS1 endocytosis. Modulates cell proliferation, abscisic acid (ABA) and drought stress signal transduction by acting in a hexokinase-independent glucose-signaling pathway. [PubMed: 26528314 Involved in the shapes of leaves, the development of floral buds, the elongation of stems, siliques, and hypocotyls, the time of flowering and the regulation of guard-cell K(+) and anion channels. Important for the kinetics of voltage activation of inward K(+) current but not for the current amplitude.]
• Protein Sequence: MASGCALHGGCPSDYVAVAISVICFFVLLSRSVLPCLIHKAPRTNSSSFWIPVIQVISSFNLLFSIMMSVNLLRFRTKHWWRYCYLWAVWIEGPLGFGLLMSCRITQAFQLYFIFVKKRLPPVKSYIFLPLVLLPWIFGAAIIHATKPLNDKCHMGLQWTFPVAGLHALYVLALIAFTRAVRHVEFRFDELRDLWKGILVSATSIVIWVTAFVLNEIHEEISWLQVASRFVLLVTGGILVVVFFSISSNQPLLSQISLKKRQNFEFQRMGQALGIPDSGLLFRKEEFRPVDPNEPLDKLLLNKRFRHSFMEFADSCYAGETLHFFEEVYEHGKIPEDDSIRRIYMARHIMEKFIVAGAEMELNLSHKTRQEILTTQDLTHTDLFKNALNEVMQLIKMNLVRDYWSSIYFIKFKEEESCHEAMHKEGYSFSSPRLSSVQGSDDPFYQEHMSKSSRCSSPG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
278	Phosphorylation	QALGIPDSGLLFRKE HHHCCCCCCCEECCH		17317660
428	Phosphorylation	AMHKEGYSFSSPRLS HHHHCCCCCCCCCHH		22940907

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGS1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
435	S	Phosphorylation	Also phosphorylated at Ser-435 or Ser-436.	22940907
436	S	Phosphorylation	Also phosphorylated at Ser-435 or Ser-436.	22940907

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSK21_ARATH	CKA1	physical	21952135
TGA1_ARATH	TGA1	physical	21952135
CVIF2_ARATH	C/VIF2	physical	21952135
PER71_ARATH	AT5G64120	physical	21952135
XTH22_ARATH	TCH4	physical	21952135
PER66_ARATH	AT5G51890	physical	21952135
PAT1_ARATH	PAT1	physical	21952135
GAUT4_ARATH	GAUT4	physical	21952135
B561J_ARATH	AT5G47530	physical	21952135
PHL1_ARATH	AT5G29000	physical	21952135
PP18_ARATH	TOPP8	physical	21952135
EBF2_ARATH	EBF2	physical	21952135
KNAT3_ARATH	KNAT3	physical	21952135
SUSY1_ARATH	SUS1	physical	21952135
SPX1_ARATH	SPX1	physical	21952135
NADB_ARATH	AO	physical	21952135
LIP2_ARATH	MPL1	physical	21952135
SYP31_ARATH	SYP31	physical	21952135
OFP1_ARATH	OFP1	physical	21952135
CB4A_ARATH	LHCB4.1	physical	21952135
Y4372_ARATH	AT4G37250	physical	21952135
SCL15_ARATH	AT4G36710	physical	21952135
STR15_ARATH	SEN1	physical	21952135
APX6_ARATH	APX6	physical	21952135
CAP1_ARATH	AT4G32285	physical	21952135
SODF1_ARATH	FSD1	physical	21952135
ZHD2_ARATH	HB22	physical	21952135
PYRC_ARATH	PYR4	physical	21952135
SYP23_ARATH	SYP23	physical	21952135
B651B_ARATH	AT4G17280	physical	21952135
SCL13_ARATH	SCL13	physical	21952135
PPD_ARATH	MES16	physical	21952135
MYB6_ARATH	MYB6	physical	21952135
EXO_ARATH	EXO	physical	21952135
PER37_ARATH	AT4G08770	physical	21952135
CUT1A_ARATH	AT4G01150	physical	21952135
PRN1_ARATH	PRN	physical	21952135
C3H47_ARATH	SZF1	physical	21952135
SRS6_ARATH	SRS6	physical	21952135
LRK42_ARATH	AT3G53810	physical	21952135
ACOX4_ARATH	ACX4	physical	21952135
MS5L2_ARATH	AT3G51280	physical	21952135
CSK22_ARATH	CKA2	physical	21952135
ABIL2_ARATH	ABIL2	physical	21952135
PER34_ARATH	PRXCB	physical	21952135
SELT_ARATH	SELT	physical	21952135
ZAT8_ARATH	AT3G46080	physical	21952135
SUS4_ARATH	SUS4	physical	21952135
PER32_ARATH	AT3G32980	physical	21952135
RGS1_ARATH	RGS1	physical	21952135
ERF83_ARATH	ERF7	physical	21952135
PUB29_ARATH	PUB29	physical	21952135
NAI2_ARATH	NAI2	physical	21952135
ESM1_ARATH	ESM1	physical	21952135
RSH2C_ARATH	RSH2	physical	21952135
CHIB_ARATH	HCHIB	physical	21952135
NDUA6_ARATH	AT3G12260	physical	21952135
KPK1_ARATH	PK1	physical	21952135
KPK2_ARATH	S6K2	physical	21952135
OBE1_ARATH	OBE1	physical	21952135
U80A2_ARATH	AT3G07020	physical	21952135
BPM2_ARATH	BPM2	physical	21952135
6GPD3_ARATH	AT3G02360	physical	21952135
MPPB_ARATH	MPPBETA	physical	21952135
CD48C_ARATH	CDC48C	physical	21952135
PHR2_ARATH	PHR2	physical	21952135
RAH1B_ARATH	RAB6A	physical	21952135
CISY4_ARATH	ATCS	physical	21952135
CTU1_ARATH	ROL5	physical	21952135
C98A3_ARATH	CYP98A3	physical	21952135
C3H29_ARATH	CZF1	physical	21952135
HSPR2_ARATH	HSPRO2	physical	21952135
NDADB_ARATH	AT2G33220	physical	21952135
VA722_ARATH	SAR1	physical	21952135
PSBW_ARATH	PSBW	physical	21952135
SODC2_ARATH	CSD2	physical	21952135
MTND1_ARATH	ARD3	physical	21952135
GPA1_ARATH	GP ALPHA 1	physical	21952135
BPC4_ARATH	BPC4	physical	21952135
THF1_ARATH	PSB29	physical	21952135
GGH3_ARATH	GGH3	physical	21952135
BLH3_ARATH	BLH3	physical	21952135
CHLP_ARATH	AT1G74470	physical	21952135
PRI2_ARATH	AT1G67320	physical	21952135
DI191_ARATH	DI19	physical	21952135
RSH3C_ARATH	RSH3	physical	21952135
CSE_ARATH	LysoPL2	physical	21952135
2ABA_ARATH	B ALPHA	physical	21952135
SDH5_ARATH	SDH5	physical	21952135
VOZ1_ARATH	VOZ1	physical	21952135
CAF1D_ARATH	AT1G27890	physical	21952135
ADHL1_ARATH	AT1G22430	physical	21952135
VATB3_ARATH	AT1G20260	physical	21952135
PTHC_ARATH	AT1G18440	physical	21952135
GBLPA_ARATH	ATARCA	physical	21952135
R10A1_ARATH	AT1G08360	physical	21952135
KSG9_ARATH	GSK1	physical	21952135
Y1500_ARATH	AT1G05000	physical	21952135
GPA1_ARATH	GP ALPHA 1	physical	22310500
GNAI1_HUMAN	GNAI1	physical	22310500
HHP2_ARATH	HHP2	physical	24833385
POT7_ARATH	KUP7	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385
PLDG3_ARATH	PLDGAMMA3	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.