KPK2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPK2_ARATH
• UniProt AC: Q39030
• Protein Name: Serine/threonine-protein kinase AtPK2/AtPK19
• Gene Name: ATPK2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 471
• Protein Description: Downstream effector of TOR signaling pathway. May be involved in adaptation of plant to cold or high-salt conditions..
• Protein Sequence: MVSSQCSVANKNQTGKPFQKHLSLSISPPKSVLGDNLELQFSDVFGPMPEANSEEACDVAYDEPAVVYSRSHSLVGPSLVVSHSLKMNKLTLRETEDSVDLVECVEGESIKENDEFSGNDDTDSEKSPEEVSGVVGIEDFEVLKVVGQGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNHAEYMKAERDILTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDVDGHVMLTDFGLAKEFEENTRSNSMCGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPFLGSKGKIQQKIVKDKIKLPQFLSNEAHALLKGLLQKEPERRLGSGPSGAEEIKKHKWFKAINWKKLEAREVQPSFKPAVSGRQCIANFDKCWTDMSVLDSPASSPNSDAKANPFTNFTYVRPPHSFLHRTTSNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
296	Phosphorylation	EENTRSNSMCGTTEY HHHCCCCCCCCCCCC	19.39	16377759
455	Phosphorylation	ANPFTNFTYVRPPHS CCCCCCCEEECCCCH	24.15	22134914

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
296	S	Phosphorylation	Kinase	PDPK1	Q9XF67	Uniprot
455	T	Phosphorylation	Kinase	TOR	Q9FR53	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
455	T	Phosphorylation	Phosphorylated at Thr-455 by TOR.	22134914

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPK2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAP46_ARATH	TAP46	physical	25399018

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Rapamycin and glucose-target of rapamycin (TOR) protein signaling inplants.";
Xiong Y., Sheen J.;
J. Biol. Chem. 287:2836-2842(2012).
Cited for: PHOSPHORYLATION AT THR-455 BY TOR.
PubMed: 22134914