dbPTM

PLDG3_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PLDG3_ARATH
UniProt AC	Q9T052
Protein Name	Phospholipase D gamma 3 {ECO:0000303\|PubMed:11891260}
Gene Name	PLDGAMMA3 {ECO:0000303\|PubMed:11891260}
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	866
Subcellular Localization	Cytoplasm . Membrane Peripheral membrane protein . Found mainly associated with intracellular membranes but also with mitochondrial membranes, nuclei and clathrin-coated vesicles. Not found in chloroplast.
Protein Description	Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence. Can use phosphatidylserine but prefers ethanolamine-containing lipids as substrates..
Protein Sequence	MAYHPVYNETMSMGGGSSNEFGQWLDKQLVPFDTSSGSLRVELLHGNLDIWVKEAKHLPNMDGFHNTLVGGMFFGLGRRNHKVDGENSSKITSDPYVTVSISGAVIGRTFVISNSENPVWMQHFDVPVAHSAAKVHFVVKDSDIIGSQIIGAVEIPTEQLCSGNRIEGLFPILNSRGKPCKQGAVLSLSIQYIPMERMRLYQKGVGFGVECVGVPGTYFPLRKGGRVTLYQDAHVDDGTLPSVHLDGGIQYRHGKCWEDMADAIRRARRLIYITGWSVFHPVRLVRRNNDPTQGTLGELLKVKSQEGVRVLVLVWDDPTSRSLLGFSTKGLMNTSDEETRRFFKHSSVQVLLCPRYGGKGHSFIKKSEVETIYTHHQKTMIVDAEAAQNRRKIVAFVGGLDLCNGRFDTPKHPLFRTLKTIHKDDFHNPNFVTTADDGPREPWHDLHSKIDGPAAYDVLANFEERWMKASKPRGIGRLRTSSDDSLLRLDRIPDIMGLSEASSANDNDPESWHVQVFRSIDSSSVKGFPKDPKEATGRNLLCGKNILIDMSIHAAYVKAIRSAQHFIYIENQYFLGSSFNWDSNKNLGANNLIPMEIALKIANKIRAREKFAAYIVIPMWPEGAPTSNPIQRILYWQHKTMQMMYQTIYKALVEVGLDGQLEPQDFLNFFCLGTREVGTREVPDGTVSVYNSPRKPPQLNAAQVQALKSRRFMIYVHSKGMVVDDEFVLIGSANINQRSLEGTRDTEIAMGGYQPHHSWAKKGSRPRGQIFGYRMSLWAEHLGFLEQEFEEPENMECVRRVRQLSELNWRQYAAEEVTEMPGHLLKYPVQVDRTGKVSSLPGYETFPDLGGKIIGSFLVVEENLTI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
448	Phosphorylation	EPWHDLHSKIDGPAA CCHHHHHHCCCCHHH	38.31	24243849
480	Phosphorylation	RGIGRLRTSSDDSLL CCCCCCCCCCCCCCH	36.85	25561503
481	Phosphorylation	GIGRLRTSSDDSLLR CCCCCCCCCCCCCHH	25.90	25561503
482	Phosphorylation	IGRLRTSSDDSLLRL CCCCCCCCCCCCHHH	44.84	25561503
692	Phosphorylation	GTVSVYNSPRKPPQL CEEEEECCCCCCCCC	14.37	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PLDG3_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PLDG3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PLDG3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PLDG3_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PLDG3_ARATH

Related Literatures of Post-Translational Modification