GPA1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPA1_ARATH
• UniProt AC: P18064
• Protein Name: Guanine nucleotide-binding protein alpha-1 subunit {ECO:0000303|PubMed:2111018}
• Gene Name: GPA1 {ECO:0000303|PubMed:2111018}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 383
• Subcellular Localization: Cell membrane .
• Protein Description: Exhibits a fast rate of basal nucleotide exchange. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Together with GCR1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate (IP(3)) as a second messenger. Promotes abscisic acid (ABA) responses in guard cells. But, together with GCR1 and GB1, acts as a negative regulator of ABA during seed germination and early seedling development. Involved in the blue light (BL) signaling. Together with GCR1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings. Modulates root architecture (e.g. lateral root formation). Negatively regulated by RGS1..
• Protein Sequence: MGLLCSRSRHHTEDTDENTQAAEIERRIEQEAKAEKHIRKLLLLGAGESGKSTIFKQIKLLFQTGFDEGELKSYVPVIHANVYQTIKLLHDGTKEFAQNETDSAKYMLSSESIAIGEKLSEIGGRLDYPRLTKDIAEGIETLWKDPAIQETCARGNELQVPDCTKYLMENLKRLSDINYIPTKEDVLYARVRTTGVVEIQFSPVGENKKSGEVYRLFDVGGQRNERRKWIHLFEGVTAVIFCAAISEYDQTLFEDEQKNRMMETKELFDWVLKQPCFEKTSFMLFLNKFDIFEKKVLDVPLNVCEWFRDYQPVSSGKQEIEHAYEFVKKKFEELYYQNTAPDRVDRVFKIYRTTALDQKLVKKTFKLVDETLRRRNLLEAGLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGLLCSRSR ------CCCCCCCCC	27.62	-
2	Myristoylation	------MGLLCSRSR ------CCCCCCCCC	27.62	12912986
5	S-palmitoylation	---MGLLCSRSRHHT ---CCCCCCCCCCCC	3.69	17158913
12	Phosphorylation	CSRSRHHTEDTDENT CCCCCCCCCCCCCHH	29.45	19880383
15	Phosphorylation	SRHHTEDTDENTQAA CCCCCCCCCCHHHHH	38.69	19880383
19	Phosphorylation	TEDTDENTQAAEIER CCCCCCHHHHHHHHH	19.96	20374526
49	Phosphorylation	LLLGAGESGKSTIFK HHHCCCCCCCCHHHH	51.07	19880383
166	Phosphorylation	QVPDCTKYLMENLKR CCCHHHHHHHHHHHH	7.98	20374526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPA1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPA1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPA1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GCR1_ARATH	GCR1	physical	15155892
PRN1_ARATH	PRN	physical	12837948
GTG2_ARATH	GTG2	physical	19135895
GTG1_ARATH	GTG1	physical	19135895
PLDA1_ARATH	PLDALPHA1	physical	14594812
AROD3_ARATH	PD1	physical	16415218
THF1_ARATH	PSB29	physical	16582010
MTND4_ARATH	ARD4	physical	21952135
TCP7_ARATH	AT5G23280	physical	21952135
CAS_ARATH	CaS	physical	21952135
SPX1_ARATH	SPX1	physical	21952135
Y5659_ARATH	LRR1	physical	21952135
DEF1B_ARATH	PDF1B	physical	21952135
KN14A_ARATH	KAC1	physical	21952135
MYB32_ARATH	MYB32	physical	21952135
CPY57_ARATH	AT4G33060	physical	21952135
SODF1_ARATH	FSD1	physical	21952135
SYP23_ARATH	SYP23	physical	21952135
EIF3A_ARATH	EIF3A	physical	21952135
PRN1_ARATH	PRN	physical	21952135
TCP16_ARATH	TCP16	physical	21952135
RGS1_ARATH	RGS1	physical	21952135
AGP16_ARATH	AGP16	physical	21952135
BAG6_ARATH	BAG6	physical	21952135
TCP9_ARATH	AT2G45680	physical	21952135
VOZ2_ARATH	VOZ2	physical	21952135
RS252_ARATH	AT2G21580	physical	21952135
THF1_ARATH	PSB29	physical	21952135
XTH4_ARATH	XTH4	physical	21952135
TCP3_ARATH	TCP3	physical	21952135
VOZ1_ARATH	VOZ1	physical	21952135
CSN5A_ARATH	CSN5A	physical	21952135
AROD1_ARATH	ADT1	physical	21952135
CDPK1_ARATH	CPK1	physical	22737156
GDU2_ARATH	GDU2	physical	22737156
CAAT9_ARATH	CAT9	physical	22737156
PLDA1_ARATH	PLDALPHA1	physical	25187041
RGS1_ARATH	RGS1	physical	15313574
CERK1_ARATH	CERK1	physical	26414709
Y5838_ARATH	BIR1	physical	26414709
BAK1_ARATH	BAK1	physical	26414709

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Unexpected protein families including cell defense components featurein the N-myristoylome of a higher eukaryote.";
Boisson B., Giglione C., Meinnel T.;
J. Biol. Chem. 278:43418-43429(2003).
Cited for: N-MYRISTOYLATION.
PubMed: 12912986