CPY57_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPY57_ARATH
• UniProt AC: Q6Q152
• Protein Name: Peptidyl-prolyl cis-trans isomerase CYP57
• Gene Name: CYP57
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 504
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Involved in plant response to pathogen infection by increasing PAD4 expression in absence of EDS1 up-regulation..
• Protein Sequence: MSTVYVLEPPTKGKVIVNTTHGPIDVELWPKEAPKSVRNFVQLCLEGYFDNTIFHRVIPGFLVQGGDPTGSGTGGDSIYGGVFADEFHSRLRFSHRGIVAMANASSPNSNGSQFFFTLDKCDWLDKKHTIFGKVTGDSIYNLLRLGEVDTSKDDRPLDPAPKILSVEVLWNPFEDIVPRVLAKTSEESAAEIKEPPTKPVKKLNLLSFGEEAEEEEKELAVVKQKIKSSHDVLNDPRLLKAEASDKERNASESKEVLSVREALNAKKEAAQKDKSFSVSDTVGNSDDDDDGEDETKFDAKMRNQVLSRRKEIGDTPSKPTQKKKSSSLKGREESTQRSDAVSSEDEKPRMEKLSLKKKGIGSEAKAEHMEKGDTDLQLYNASERARQLHKLKKRRLQGNEDSVLAKLEKFKQSISAKPFTSSNEPVVLTSSSEPVDNKEEDLSDWKNVKLKFAPERGKDKMSRRDDPDAYMVVDPLLEKGKEKFNRMQAKQKRREREWSGKSLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTVYVLEP ------CCEEEEECC		22223895
228	Phosphorylation	VVKQKIKSSHDVLND HHHHHHHHCHHHHCC		25561503
275	Phosphorylation	EAAQKDKSFSVSDTV HHHHHCCCCCCCCCC		23776212
277	Phosphorylation	AQKDKSFSVSDTVGN HHHCCCCCCCCCCCC		23776212
279	Phosphorylation	KDKSFSVSDTVGNSD HCCCCCCCCCCCCCC		23776212
281	Phosphorylation	KSFSVSDTVGNSDDD CCCCCCCCCCCCCCC		23776212
285	Phosphorylation	VSDTVGNSDDDDDGE CCCCCCCCCCCCCCC		23776212
338	Phosphorylation	REESTQRSDAVSSED CHHHHCHHCCCCCCC		23776212
342	Phosphorylation	TQRSDAVSSEDEKPR HCHHCCCCCCCCCCH		23776212
343	Phosphorylation	QRSDAVSSEDEKPRM CHHCCCCCCCCCCHH		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPY57_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPY57_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPY57_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of CPY57_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.