CERK1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CERK1_ARATH
• UniProt AC: A8R7E6
• Protein Name: Chitin elicitor receptor kinase 1
• Gene Name: CERK1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 617
• Subcellular Localization: Cell membrane ; Single-pass membrane protein .
• Protein Description: Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP). Plays an essential role in detecting peptidoglycans (e.g. PGNs) and restricting bacterial growth. Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv. tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI). Mediates chitin-induced phosphorylation of PBL27. [PubMed: 24750441]
• Protein Sequence: MKLKISLIAPILLLFSFFFAVESKCRTSCPLALASYYLENGTTLSVINQNLNSSIAPYDQINFDPILRYNSNIKDKDRIQMGSRVLVPFPCECQPGDFLGHNFSYSVRQEDTYERVAISNYANLTTMESLQARNPFPATNIPLSATLNVLVNCSCGDESVSKDFGLFVTYPLRPEDSLSSIARSSGVSADILQRYNPGVNFNSGNGIVYVPGRDPNGAFPPFKSSKQDGVGAGVIAGIVIGVIVALLLILFIVYYAYRKNKSKGDSFSSSIPLSTKADHASSTSLQSGGLGGAGVSPGIAAISVDKSVEFSLEELAKATDNFNLSFKIGQGGFGAVYYAELRGEKAAIKKMDMEASKQFLAELKVLTRVHHVNLVRLIGYCVEGSLFLVYEYVENGNLGQHLHGSGREPLPWTKRVQIALDSARGLEYIHEHTVPVYVHRDIKSANILIDQKFRAKVADFGLTKLTEVGGSATRGAMGTFGYMAPETVYGEVSAKVDVYAFGVVLYELISAKGAVVKMTEAVGEFRGLVGVFEESFKETDKEEALRKIIDPRLGDSYPFDSVYKMAELGKACTQENAQLRPSMRYIVVALSTLFSSTGNWDVGNFQNEDLVSLMSGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	N-linked_Glycosylation	LASYYLENGTTLSVI HHHHHHHCCCEEEEE		22654057
52	N-linked_Glycosylation	SVINQNLNSSIAPYD EEEECCCCCCCCCHH		22654057
102	N-linked_Glycosylation	PGDFLGHNFSYSVRQ CCCCCCCCCEEEEEC		22654057
123	N-linked_Glycosylation	VAISNYANLTTMESL EEEECCCCCCHHHHH		22654057
152	N-linked_Glycosylation	ATLNVLVNCSCGDES EEEEEEEECCCCCCC		22654057
185	Phosphorylation	LSSIARSSGVSADIL HHHHHHHCCCCHHHH		29797451
266	Phosphorylation	KNKSKGDSFSSSIPL HCCCCCCCCCCCCCC		20610395
268	Phosphorylation	KSKGDSFSSSIPLST CCCCCCCCCCCCCCC		20610395
270	Phosphorylation	KGDSFSSSIPLSTKA CCCCCCCCCCCCCCC		22654057
274	Phosphorylation	FSSSIPLSTKADHAS CCCCCCCCCCCCCCC		20610395
281	Phosphorylation	STKADHASSTSLQSG CCCCCCCCCCCCCCC		27288362
282	Phosphorylation	TKADHASSTSLQSGG CCCCCCCCCCCCCCC		27288362
283	Phosphorylation	KADHASSTSLQSGGL CCCCCCCCCCCCCCC		27288362
284	Phosphorylation	ADHASSTSLQSGGLG CCCCCCCCCCCCCCC		27288362
287	Phosphorylation	ASSTSLQSGGLGGAG CCCCCCCCCCCCCCC		17317660
296	Phosphorylation	GLGGAGVSPGIAAIS CCCCCCCCCCEEEEE		27288362
303	Phosphorylation	SPGIAAISVDKSVEF CCCEEEEECCCCCEE		27288362
390	Phosphorylation	EGSLFLVYEYVENGN HCEEEEEEEEHHCCC		-
466	Phosphorylation	DFGLTKLTEVGGSAT HCCCEEEEEECCCCC		19880383
479	Phosphorylation	ATRGAMGTFGYMAPE CCCCCCCCCCCCCCC		-
519	Phosphorylation	KGAVVKMTEAVGEFR CCCEEEHHHHHHHHH		24750441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CERK1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CERK1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CERK1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CERK1_ARATH	CERK1	physical	25070640
APX1_ARATH	APX1	physical	25036661
SODC1_ARATH	CSD1	physical	25036661
TRXH4_ARATH	ATTRX4	physical	25036661
FNRL2_ARATH	FNR2	physical	25036661
IF5A2_ARATH	FBR12	physical	25036661
ACBP6_ARATH	ACBP6	physical	25036661
G3PB_ARATH	GAPB	physical	25036661
ERF82_ARATH	ERF3	physical	25036661
BGL18_ARATH	BGLU18	physical	25036661
FER2_ARATH	FED A	physical	25036661
KCS10_ARATH	KCS10	physical	25036661
CID7_ARATH	CID7	physical	25036661
SODC2_ARATH	CSD2	physical	25036661
PP14_ARATH	TOPP4	physical	25036661
SPCS2_ARATH	AT2G39960	physical	25036661
IQD14_ARATH	IQD14	physical	25036661
SPL3_ARATH	SPL3	physical	25036661
NLTP6_ARATH	LTP6	physical	25036661
CML36_ARATH	AT3G10190	physical	25036661
PSA5B_ARATH	PAE2	physical	25036661
Y3148_ARATH	AT3G14840	physical	25036661
Y3684_ARATH	AT3G26840	physical	25036661
NACA2_ARATH	NACA2	physical	25036661
SUT31_ARATH	SULTR3;1	physical	25036661
CAB6_ARATH	LHCA1	physical	25036661
MED21_ARATH	MED21	physical	25036661
PIP27_ARATH	PIP3	physical	25036661
AGP18_ARATH	AGP18	physical	25036661
UBQ3_ARATH	UBQ3	physical	25036661
GRP17_ARATH	GRP17	physical	25036661
KIN1_ARATH	KIN1	physical	25036661
EF1B2_ARATH	AT5G19510	physical	25036661
PIST_ARATH	PI	physical	25036661
GRXC4_ARATH	AT5G20500	physical	25036661
VSP2_ARATH	VSP2	physical	25036661
DIRL1_ARATH	DIR1	physical	25036661
RH35_ARATH	AT5G51280	physical	25036661
CIPK7_ARATH	CIPK7	physical	24833385
AKT6_ARATH	SPIK	physical	24833385
WNK8_ARATH	WNK8	physical	24833385
ANXD1_ARATH	ANNAT1	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
CHX28_ARATH	chx28	physical	24833385
LYK5_ARATH	AT2G33580	physical	25340959
CERK1_ARATH	CERK1	physical	25340959

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.