IF5A2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF5A2_ARATH
• UniProt AC: Q93VP3
• Protein Name: Eukaryotic translation initiation factor 5A-2
• Gene Name: ELF5A-2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 159
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: The precise role of eIF-5A in protein biosynthesis is not known but it may function as a bimodular protein capable of binding to both RNA and proteins. Regulates cytokinin-mediated root protoxylem specification and represses secifically the expression of AHP6. Regulates the induction of programmed cell death caused by infection with virulent pathogen..
• Protein Sequence: MSDDEHHFEASESGASKTYPQSAGNIRKGGHIVIKNRPCKVVEVSTSKTGKHGHAKCHFVAIDIFTAKKLEDIVPSSHNCDVPHVNRVDYQLIDITEDGFVSLLTDSGGTKDDLKLPTDDGLTAQMRLGFDEGKDIVVSVMSSMGEEQICAVKEVGGGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDDEHHFE ------CCCCCCCEE	54.49	30291188
11	Phosphorylation	DEHHFEASESGASKT CCCCEECCCCCCCCC	25.71	23172892
13	Phosphorylation	HHFEASESGASKTYP CCEECCCCCCCCCCC	36.84	25561503
16	Phosphorylation	EASESGASKTYPQSA ECCCCCCCCCCCCCC	29.11	25561503
51	Hypusine	VSTSKTGKHGHAKCH EECCCCCCCCCCEEE	52.20	-
51	Other	VSTSKTGKHGHAKCH EECCCCCCCCCCEEE	52.20	-
76	Phosphorylation	KLEDIVPSSHNCDVP HHHHCCCCCCCCCCC	33.08	19880383
77	Phosphorylation	LEDIVPSSHNCDVPH HHHCCCCCCCCCCCC	16.79	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF5A2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF5A2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF5A2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AHP1_ARATH	AHP1	physical	24163315
AHK4_ARATH	WOL	physical	24163315

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASSSPECTROMETRY.
PubMed: 19376835