dbPTM

PIP27_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PIP27_ARATH
UniProt AC	P93004
Protein Name	Aquaporin PIP2-7
Gene Name	PIP2-7
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	280
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Water channel required to facilitate the transport of water across cell membrane. May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition..
Protein Sequence	MSKEVSEEGKTHHGKDYVDPPPAPLLDMGELKSWSFYRALIAEFIATLLFLYVTVATVIGHKKQTGPCDGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLVRALGYMIAQCLGAICGVGFVKAFMKTPYNTLGGGANTVADGYSKGTALGAEIIGTFVLVYTVFSATDPKRSARDSHIPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKAWDDQWIFWVGPFLGALAAAAYHQYILRASAIKALGSFRSNATN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MSKEVSEE -------CCHHCCCC	13.41	-
2	Phosphorylation	------MSKEVSEEG ------CCHHCCCCC	37.21	25561503
3	"N6,N6-dimethyllysine"	-----MSKEVSEEGK -----CCHHCCCCCC	61.92	-
3	Methylation	-----MSKEVSEEGK -----CCHHCCCCCC	61.92	-
6	Phosphorylation	--MSKEVSEEGKTHH --CCHHCCCCCCCCC	30.90	19880383
11	Phosphorylation	EVSEEGKTHHGKDYV HCCCCCCCCCCCCCC	29.93	25561503
266	Phosphorylation	HQYILRASAIKALGS HHHHHHHHHHHHHHH	24.88	19376835
273	Phosphorylation	SAIKALGSFRSNATN HHHHHHHHHHHCCCC	20.52	30291188
276	Phosphorylation	KALGSFRSNATN--- HHHHHHHHCCCC---	28.89	19880383
279	Phosphorylation	GSFRSNATN------ HHHHHCCCC------	45.79	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PIP27_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PIP27_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PIP27_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAC89_ARATH	NAC089	physical	21798944
SY121_ARATH	SYP121	physical	25082856
SYP61_ARATH	SYP61	physical	25082856
PIP27_ARATH	PIP3	physical	25082856
TSPO_ARATH	TSPO	physical	25538184
PIP15_ARATH	PIP1;5	physical	24833385
UTR2_ARATH	UTR2	physical	24833385
HHP2_ARATH	HHP2	physical	24833385
HHP4_ARATH	HHP4	physical	24833385
PIP14_ARATH	PIP1;4	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
ACBP6_ARATH	ACBP6	physical	24833385
PIP22_ARATH	PIP2B	physical	24833385
ELIP2_ARATH	ELIP2	physical	24833385
HSDD3_ARATH	AT2G43420	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385
BETL2_ARATH	AT1G29060	physical	24833385
VAP21_ARATH	AT5G47180	physical	24833385

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PIP27_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-276 ANDTHR-279, AND MASS SPECTROMETRY.	19376835 [Abstract]
"Novel subsets of the Arabidopsis plasmalemma phosphoproteome identifyphosphorylation sites in secondary active transporters."; Hem S., Rofidal V., Sommerer N., Rossignol M.; Biochem. Biophys. Res. Commun. 363:375-380(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-276 ANDTHR-279, AND MASS SPECTROMETRY.	17869214 [Abstract]
"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database."; Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.; Plant Cell 16:2394-2405(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273, AND MASSSPECTROMETRY.	15308754 [Abstract]