dbPTM

PIP14_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PIP14_ARATH
UniProt AC	Q39196
Protein Name	Probable aquaporin PIP1-4
Gene Name	PIP1.4
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	287
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes..
Protein Sequence	MEGKEEDVRVGANKFPERQPIGTSAQSTDKDYKEPPPAPLFEPGELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVFYMIMQCLGAICGAGVVKGFQPTPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHSWDDHWIFWVGPFIGAALAALYHQIVIRAIPFKSKS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGKEEDV -------CCCCHHHC	16.10	16839310
24	Phosphorylation	ERQPIGTSAQSTDKD CCCCCCCCCCCCCCC	21.06	30407730
27	Phosphorylation	PIGTSAQSTDKDYKE CCCCCCCCCCCCCCC	37.99	30407730
28	Phosphorylation	IGTSAQSTDKDYKEP CCCCCCCCCCCCCCC	34.68	30407730
285	Phosphorylation	IRAIPFKSKS----- HHHCCCCCCC-----	38.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PIP14_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PIP14_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PIP14_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIP27_ARATH	PIP3	physical	21798944
PIP25_ARATH	PIP2;5	physical	24833385
PIP13_ARATH	PIP1C	physical	24833385
PIP22_ARATH	PIP2B	physical	24833385
FACE2_ARATH	FACE2	physical	24833385
PIP21_ARATH	PIP2A	physical	24833385
Y1747_ARATH	AT1G67470	physical	24833385

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PIP14_ARATH

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Methylation of aquaporins in plant plasma membrane."; Santoni V., Verdoucq L., Sommerer N., Vinh J., Pflieger D., Maurel C.; Biochem. J. 400:189-197(2006). Cited for: ACETYLATION AT MET-1, AND MASS SPECTROMETRY.	16839310 [Abstract]