PIP13_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIP13_ARATH
• UniProt AC: Q08733
• Protein Name: Aquaporin PIP1-3
• Gene Name: PIP1-3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 286
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Water channel required to facilitate the transport of water across cell membrane. Its function is impaired by Hg(2+)..
• Protein Sequence: MEGKEEDVRVGANKFPERQPIGTSAQTDKDYKEPPPAPFFEPGELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVFYIVMQCLGAICGAGVVKGFQPNPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIYNKDHAWDDHWIFWVGPFIGAALAALYHQLVIRAIPFKSRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGKEEDV -------CCCCHHHC	16.10	16839310
1	Sulfoxidation	-------MEGKEEDV -------CCCCHHHC	16.10	25693801
284	Phosphorylation	IRAIPFKSRS----- HHHCCCCCCC-----	37.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIP13_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIP13_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIP13_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIP27_ARATH	PIP3	physical	21798944
PIP23_ARATH	RD28	physical	21798944
PIP25_ARATH	PIP2;5	physical	21798944
PIP28_ARATH	PIP2;8	physical	21798944
PIP26_ARATH	PIP2E	physical	21798944
NAC89_ARATH	NAC089	physical	21798944
PIP25_ARATH	PIP2;5	physical	24833385
PIP15_ARATH	PIP1;5	physical	24833385
LUT1_ARATH	LUT1	physical	24833385
UTR2_ARATH	UTR2	physical	24833385
HHP4_ARATH	HHP4	physical	24833385
HHP1_ARATH	HHP1	physical	24833385
PIP22_ARATH	PIP2B	physical	24833385
FACE2_ARATH	FACE2	physical	24833385
LPAT2_ARATH	LPAT2	physical	24833385
AGP27_ARATH	AGP27	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
C71B6_ARATH	CYP71B6	physical	24833385
HSDD3_ARATH	AT2G43420	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385
RBL14_ARATH	RBL14	physical	24833385
RUS3_ARATH	RUS3	physical	24833385
BET12_ARATH	ATBET12	physical	24833385
TRXH7_ARATH	TH7	physical	24833385
MMGT_ARATH	AT5G03345	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Methylation of aquaporins in plant plasma membrane.";
Santoni V., Verdoucq L., Sommerer N., Vinh J., Pflieger D., Maurel C.;
Biochem. J. 400:189-197(2006).
Cited for: ACETYLATION AT MET-1, AND MASS SPECTROMETRY.
PubMed: 16839310