PIP28_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIP28_ARATH
• UniProt AC: Q9ZVX8
• Protein Name: Probable aquaporin PIP2-8
• Gene Name: PIP2-8
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 278
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes..
• Protein Sequence: MSKEVSEEGRHGKDYVDPPPAPLLDMAELKLWSFYRAIIAEFIATLLFLYVTVATVIGHKNQTGPCGGVGLLGIAWAFGGMIFVLVYCTAGISGGHINPAVTFGLFLARKVSLPRAVAYMVAQCLGAICGVGLVKAFMMTPYKRLGGGANTVADGYSTGTALGAEIIGTFVLVYTVFSATDPKRSARDSHVPVLAPLPIGFAVFMVHLATIPITGTGINPARSFGAAVIYNNEKAWDDHWIFWVGPFVGALAAAAYHQYILRAAAIKALASFRSNPTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MSKEVSEE -------CCCCCCCC	13.41	-
2	Phosphorylation	------MSKEVSEEG ------CCCCCCCCC	37.21	25561503
3	"N6,N6-dimethyllysine"	-----MSKEVSEEGR -----CCCCCCCCCC	61.92	-
3	Methylation	-----MSKEVSEEGR -----CCCCCCCCCC	61.92	-
6	Phosphorylation	--MSKEVSEEGRHGK --CCCCCCCCCCCCC	30.90	25561503
151	Phosphorylation	RLGGGANTVADGYST CCCCCCCCCCCCCCC	19.28	25368622
156	Phosphorylation	ANTVADGYSTGTALG CCCCCCCCCCCHHHH	12.01	25368622
157	Phosphorylation	NTVADGYSTGTALGA CCCCCCCCCCHHHHH	26.37	25368622
158	Phosphorylation	TVADGYSTGTALGAE CCCCCCCCCHHHHHH	30.02	25368622
160	Phosphorylation	ADGYSTGTALGAEII CCCCCCCHHHHHHHE	20.85	25368622
271	Phosphorylation	AAIKALASFRSNPTN HHHHHHHHHHCCCCC	23.26	19880383
274	Phosphorylation	KALASFRSNPTN--- HHHHHHHCCCCC---	45.19	19880383
277	Phosphorylation	ASFRSNPTN------ HHHHCCCCC------	58.78	23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIP28_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIP28_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIP28_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAC89_ARATH	NAC089	physical	21798944
PIP12_ARATH	PIP1B	physical	21798944
PIP23_ARATH	RD28	physical	21798944
PIP14_ARATH	PIP1;4	physical	21798944
Y4645_ARATH	AT4G26450	physical	21798944
NIP11_ARATH	NLM1	physical	21798944
PIP15_ARATH	PIP1;5	physical	21798944
PIP27_ARATH	PIP3	physical	21798944
PIP25_ARATH	PIP2;5	physical	21798944
VAP11_ARATH	VAP	physical	21798944
PIP14_ARATH	PIP1;4	physical	24833385
TCMO_ARATH	C4H	physical	24833385
POT7_ARATH	KUP7	physical	24833385
BETL2_ARATH	AT1G29060	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271; SER-274 ANDTHR-277, AND MASS SPECTROMETRY.
PubMed: 19376835