VAP11_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VAP11_ARATH
• UniProt AC: Q8VZ95
• Protein Name: Vesicle-associated protein 1-1
• Gene Name: PVA11
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 256
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . Protein storage vacuole membrane ; Single-pass type IV membrane protein ; Cytoplasmic side . Localizes to immobile punctate structures reminiscent of the ER-plasma membrane conta
• Protein Description: Part of a membrane-cytoskeletal adapter complex that forms a bridge between the endoplasmic reticulum and the plasma membrane. Associates with microtubules..
• Protein Sequence: MSNIDLIGMSNRDLIGMSNSELLTVEPLDLQFPFELKKQISCSLYLTNKTDNNVAFKVKTTNPKKYCVRPNTGVVLPRSTCEVLVTMQAQKEAPSDMQCKDKFLLQGVIASPGVTAKEVTPEMFSKEAGHRVEETKLRVTYVAPPRPPSPVHEGSEEGSSPRASVSDNGHGSEFSFERFIVDNKAGHQENTSEARALITKLTEEKQSAIQLNNRLQRELDQLRRESKKSQSGGIPFMYVLLVGLIGLILGYIMKRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MSNIDLIG -------CCCCCEEE	6.63	-
2	Acetylation	------MSNIDLIGM ------CCCCCEEEC	42.36	22223895
2	Phosphorylation	------MSNIDLIGM ------CCCCCEEEC	42.36	27288362
111	Phosphorylation	LLQGVIASPGVTAKE HHHHECCCCCCCHHH	15.86	30291188
140	Phosphorylation	EETKLRVTYVAPPRP EEEEEEEEEECCCCC	13.07	23776212
141	Phosphorylation	ETKLRVTYVAPPRPP EEEEEEEEECCCCCC	7.55	23776212
149	Phosphorylation	VAPPRPPSPVHEGSE ECCCCCCCCCCCCCC	42.09	27532006
155	Phosphorylation	PSPVHEGSEEGSSPR CCCCCCCCCCCCCCC	29.50	24601666
159	Phosphorylation	HEGSEEGSSPRASVS CCCCCCCCCCCEECC	40.21	27532006
160	Phosphorylation	EGSEEGSSPRASVSD CCCCCCCCCCEECCC	29.30	24601666
164	Phosphorylation	EGSSPRASVSDNGHG CCCCCCEECCCCCCC	24.35	19376835
166	Phosphorylation	SSPRASVSDNGHGSE CCCCEECCCCCCCCC	23.90	19688752
172	Phosphorylation	VSDNGHGSEFSFERF CCCCCCCCCEEEEEE	29.78	19376835
175	Phosphorylation	NGHGSEFSFERFIVD CCCCCCEEEEEEEEE	23.34	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VAP11_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VAP11_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VAP11_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NIP11_ARATH	NLM1	physical	21798944
TPT_ARATH	APE2	physical	21798944
PLST4_ARATH	PGLCT	physical	21798944
VAP11_ARATH	VAP	physical	21798944
MEB2_ARATH	AT5G24290	physical	21798944
Y4645_ARATH	AT4G26450	physical	21798944
PLP9_ARATH	PLP9	physical	21798944
CYB5E_ARATH	CB5-E	physical	21798944
TIP22_ARATH	TIP2;2	physical	21798944
SYP31_ARATH	SYP31	physical	21798944
PIP27_ARATH	PIP3	physical	21798944
Y4958_ARATH	AT4G09580	physical	21798944
SY132_ARATH	SYP132	physical	21798944
NAC89_ARATH	NAC089	physical	21798944
ORP2A_ARATH	ORP2A	physical	21798944
BAM8_ARATH	BMY2	physical	21798944
KMS1_ARATH	AT4G14950	physical	21798944
DME_ARATH	DME	physical	21952135
SUI11_ARATH	AT4G27130	physical	21952135
SODF1_ARATH	FSD1	physical	21952135
ACT2_ARATH	ACT2	physical	21952135
SYP71_ARATH	SYP71	physical	23696741

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-155 ANDSER-160, AND MASS SPECTROMETRY.
PubMed: 19376835

"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis.";
de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.;
J. Proteome Res. 7:2458-2470(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149 AND SER-155, ANDMASS SPECTROMETRY.
PubMed: 18433157