MEB2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEB2_ARATH
• UniProt AC: F4KFS7
• Protein Name: Membrane protein of ER body 2
• Gene Name: MEB2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 550
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Located in ER bodies.
• Protein Description: May sequester excess cytosolic iron and manganese into endoplasmic reticulum to reduce metal ion toxicity. Not essential for the accumulation of ER body components, including PYK10..
• Protein Sequence: MEKSNQPVHVTLSELKDGDKEIVDAEFLVDLLESYRFGKDNVPAREFRSKAAATAPAPVNTTEIELEEDNDGSQAQGNNSVSESTSSLFSDSDPIVLESTVSETGSNEESETGSNEENGNNWLESSSTNLPNVENKRQRNGEDCEIEEEEENNERSLSDSEEKSNLEKLLGTQENYELGNEDEEKNERSSSDSEEKSNLENLLATQENYELYCPSCSTCITRNVVLKKRKRGKHVNSSLDLKPDIPVVEPDEPSDIEEMESPVKVYVPETRIEDDQEDKEGTIFTCLVCDLKYFIRLGTKFLQLDYIRGKPVEKSVEEYIDVRKSINTTQSPPQIQPDGERFAIELLKSTVYGGLTETITSLGVVSSASASGSSTMNILALAVANLAGGLIVLAQNFQDLRNSSDQEKDRYEELLGRRTKSRIHILVAVMSYIFFGLIPPLVYAFSFYETGIKNYKLISVFLGSLVCVILLGSIKVYVRKPTNSCGSTKAYLKSAAYYTSIVVASCGISYVVGDIMGEYIEKLSLVGLDQISITSPCYGIKPEECRFTSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
140	Phosphorylation	VENKRQRNGEDCEIE CCCHHHHCCCCCCHH		24243849
142	Phosphorylation	NKRQRNGEDCEIEEE CHHHHCCCCCCHHHH		24243849
156	Phosphorylation	EEENNERSLSDSEEK HHHHCCCCCCHHHHH		19880383
158	Phosphorylation	ENNERSLSDSEEKSN HHCCCCCCHHHHHHH		19880383
160	Phosphorylation	NERSLSDSEEKSNLE CCCCCCHHHHHHHHH		25561503
237	Phosphorylation	KRGKHVNSSLDLKPD CCCCCCCCCCCCCCC		27643528
238	Phosphorylation	RGKHVNSSLDLKPDI CCCCCCCCCCCCCCC		27643528
254	Phosphorylation	VVEPDEPSDIEEMES CCCCCCCCCHHHCCC		27643528
261	Phosphorylation	SDIEEMESPVKVYVP CCHHHCCCCCEEEEC		27643528
484	Phosphorylation	YVRKPTNSCGSTKAY EEECCCCCCCCHHHH		22074104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEB2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEB2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEB2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of MEB2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.