PIP12_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIP12_ARATH
• UniProt AC: Q06611
• Protein Name: Aquaporin PIP1-2
• Gene Name: PIP1-2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 286
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Water channel required to facilitate the transport of water across cell membrane. Essential for the water permeability of the plasma membrane and for the morphology of the root system. Its function is impaired by Hg(2+). Inhibited by cytosolic acidosis which occurs during anoxia in roots..
• Protein Sequence: MEGKEEDVRVGANKFPERQPIGTSAQSDKDYKEPPPAPLFEPGELASWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDNAWDDHWVFWVGPFIGAALAALYHVIVIRAIPFKSRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGKEEDV -------CCCCHHHC	16.10	16839310
23	Phosphorylation	PERQPIGTSAQSDKD CCCCCCCCCCCCCCC	22.93	30407730
24	Phosphorylation	ERQPIGTSAQSDKDY CCCCCCCCCCCCCCC	21.06	26811356
27	Phosphorylation	PIGTSAQSDKDYKEP CCCCCCCCCCCCCCC	46.47	26811356
284	Phosphorylation	IRAIPFKSRS----- HCCCCCCCCC-----	37.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIP12_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIP12_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIP12_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIP25_ARATH	PIP2;5	physical	21798944
PIP27_ARATH	PIP3	physical	21798944
GDU2_ARATH	GDU2	physical	22737156
UTR2_ARATH	UTR2	physical	24833385
HHP2_ARATH	HHP2	physical	24833385
HHP4_ARATH	HHP4	physical	24833385
UBC32_ARATH	UBC32	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
PIP13_ARATH	PIP1C	physical	24833385
FACE2_ARATH	FACE2	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385
BET12_ARATH	ATBET12	physical	24833385
TBL18_ARATH	TBL18	physical	24833385
MMGT_ARATH	AT5G03345	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Methylation of aquaporins in plant plasma membrane.";
Santoni V., Verdoucq L., Sommerer N., Vinh J., Pflieger D., Maurel C.;
Biochem. J. 400:189-197(2006).
Cited for: ACETYLATION AT MET-1, AND MASS SPECTROMETRY.
PubMed: 16839310