SY121_ARATH - dbPTM
SY121_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SY121_ARATH
UniProt AC Q9ZSD4
Protein Name Syntaxin-121
Gene Name SYP121
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 346
Subcellular Localization Cell membrane
Single-pass type IV membrane protein .
Protein Description Vesicle trafficking protein that functions in the secretory pathway..
Protein Sequence MNDLFSSSFSRFRSGEPSPRRDVAGGGDGVQMANPAGSTGGVNLDKFFEDVESVKEELKELDRLNETLSSCHEQSKTLHNAKAVKDLRSKMDGDVGVALKKAKMIKVKLEALDRANAANRSLPGCGPGSSSDRTRTSVLNGLRKKLMDSMDSFNRLRELISSEYRETVQRRYFTVTGENPDERTLDRLISTGESERFLQKAIQEQGRGRVLDTINEIQERHDAVKDIEKNLRELHQVFLDMAVLVEHQGAQLDDIESHVGRASSFIRGGTDQLQTARVYQKNTRKWTCIAIIILIIIITVVVLAVLKPWNNSSGGGGGGGGGGTTGGSQPNSGTPPNPPQARRLLR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MNDLFSSS
-------CCHHHCCC		8.7522223895
2 (in isoform 2)Acetylation-55.4822223895
6Phosphorylation--MNDLFSSSFSRFR
--CCHHHCCCCCCCC		32.1624924143
7Phosphorylation-MNDLFSSSFSRFRS
-CCHHHCCCCCCCCC		28.2419880383
8PhosphorylationMNDLFSSSFSRFRSG
CCHHHCCCCCCCCCC		26.5017317660
10PhosphorylationDLFSSSFSRFRSGEP
HHHCCCCCCCCCCCC		32.2427643528
14PhosphorylationSSFSRFRSGEPSPRR
CCCCCCCCCCCCCCC		44.8125561503
18PhosphorylationRFRSGEPSPRRDVAG
CCCCCCCCCCCCCCC		27.0823776212
38PhosphorylationQMANPAGSTGGVNLD
CCCCCCCCCCCCCHH		26.4530407730
39PhosphorylationMANPAGSTGGVNLDK
CCCCCCCCCCCCHHH		36.7230407730
130PhosphorylationPGCGPGSSSDRTRTS
CCCCCCCCCHHHHHH		42.0225561503
152PhosphorylationKLMDSMDSFNRLREL
HHHHCHHHHHHHHHH		18.7729654922
190PhosphorylationRTLDRLISTGESERF
HHHHHHHHCCCHHHH		34.6423776212
191PhosphorylationTLDRLISTGESERFL
HHHHHHHCCCHHHHH		37.6723776212
194PhosphorylationRLISTGESERFLQKA
HHHHCCCHHHHHHHH		35.1019376835
263PhosphorylationESHVGRASSFIRGGT
HHHHHHHHHHHCCCC		25.1523172892
264PhosphorylationSHVGRASSFIRGGTD
HHHHHHHHHHCCCCC		24.5730407730
270PhosphorylationSSFIRGGTDQLQTAR
HHHHCCCCCHHHHHH		24.3223172892
275PhosphorylationGGTDQLQTARVYQKN
CCCCHHHHHHHHCCC		25.6423172892
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SY121_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SY121_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SY121_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KAT3_ARATHKAT3physical
19794113
NIP11_ARATHNLM1physical
21798944
NUP35_ARATHAT3G16310physical
21798944
KEULE_ARATHKEUphysical
23572542
SNP33_ARATHSNAP33physical
23572542
VA721_ARATHVAMP721physical
23572542
RS3A1_ARATHAT3G04840physical
24556609
NOP5B_ARATHAT3G05060physical
24556609
RL4B_ARATHAT5G02870physical
24556609
RH5_ARATHSTRS1physical
24556609
VAP42_ARATHAT4G21450physical
24556609
RL171_ARATHAT1G27400physical
24556609
MD36B_ARATHFIB1physical
24556609
MD36A_ARATHFIB2physical
24556609
EXPB3_ARATHEXPB3physical
24556609
RL312_ARATHAT4G26230physical
24556609
ADT1_ARATHAAC1physical
24556609
RPF2_ARATHAT3G23620physical
24556609
RL351_ARATHAT3G09500physical
24556609
RL354_ARATHAT5G02610physical
24556609
RL51_ARATHATL5physical
24556609
IF2B_ARATHEIF2 BETAphysical
24556609
RS91_ARATHAT5G15200physical
24556609
RL281_ARATHAT2G19730physical
24556609
JAL20_ARATHAT2G25980physical
24556609
NOP5A_ARATHAT5G27120physical
24556609
RS143_ARATHAT3G52580physical
24556609
RS241_ARATHAT3G04920physical
24556609
HIR3_ARATHAT3G01290physical
24556609
CDC5L_ARATHCDC5physical
24556609
RL282_ARATHAT4G29410physical
24556609
VA721_ARATHVAMP721physical
24556609
RS41_ARATHAT2G17360physical
24556609
ENPL_ARATHSHDphysical
24556609
SYP71_ARATHSYP71physical
24556609
ANXD4_ARATHANNAT4physical
24556609
RL121_ARATHAT2G37190physical
24556609
RL81_ARATHEMB2296physical
24556609
RS30_ARATHAT2G19750physical
24556609
RS242_ARATHAT5G28060physical
24556609
JAL34_ARATHAT3G16460physical
24556609
SNP33_ARATHSNAP33physical
18273019
VA721_ARATHVAMP721physical
18273019
VA722_ARATHSAR1physical
18273019
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SY121_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-190, AND MASSSPECTROMETRY.

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