RH5_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RH5_ARATH
• UniProt AC: Q9C551
• Protein Name: DEAD-box ATP-dependent RNA helicase 5
• Gene Name: RH5
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 537
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity)..
• Protein Sequence: MAGQKQELPVSGEPLAVESPMTNKKKKKSKKNKHTEENHEVEEVPQEVTNGVEEELSNKEKKKKRKREEKESEKNKKKDVPEKKLEAEDLGEGESEQQKVVVTGKGVEEAKYAALKTFAESNLPENVLDCCKTFEKPSPIQSHTWPFLLDGRDLIGIAKTGSGKTLAFGIPAIMHVLKKNKKIGGGSKKVNPTCLVLSPTRELAVQISDVLREAGEPCGLKSICVYGGSSKGPQISAIRSGVDIVIGTPGRLRDLIESNVLRLSDVSFVVLDEADRMLDMGFEEPVRFILSNTNKVRQMVMFSATWPLDVHKLAQEFMDPNPIKVIIGSVDLAANHDVMQIIEVLDERARDQRLIALLEKYHKSQKNRVLVFALYKVEAERLERFLQQRGWKAVSIHGNKAQSERTRSLSLFKEGSCPLLVATDVAARGLDIPDVEVVINYTFPLTTEDYVHRIGRTGRAGKKGVAHTFFTPLNKGLAGELVNVLREAGQVVPADLLKFGTHVKKKESKLYGAHFKEIAADAPKATKITFDNSDDED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	GEPLAVESPMTNKKK CCCCCCCCCCCCCCC	17.24	30291188
22	Phosphorylation	LAVESPMTNKKKKKS CCCCCCCCCCCCCCC	47.47	25561503
160	Phosphorylation	DLIGIAKTGSGKTLA EEEEEEECCCCCCHH	27.79	24894044
165	Phosphorylation	AKTGSGKTLAFGIPA EECCCCCCHHHHHHH	27.18	24894044
291	Phosphorylation	EPVRFILSNTNKVRQ CCCEEHHCCCCHHEE	36.47	24894044
529	Phosphorylation	APKATKITFDNSDDE CCCCEECEECCCCCC	26.88	23776212
533	Phosphorylation	TKITFDNSDDED--- EECEECCCCCCC---	48.56	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RH5_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RH5_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RH5_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of RH5_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533, AND MASSSPECTROMETRY.
PubMed: 19376835