WNK8_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNK8_ARATH
• UniProt AC: Q944Q0
• Protein Name: Serine/threonine-protein kinase WNK8
• Gene Name: WNK8
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 563
• Subcellular Localization: Nucleus .
• Protein Description: Regulates flowering time by modulating the photoperiod pathway. Phosphorylates the vacuolar ATPase subunit C (VATC) and RGS1. [PubMed: 16427632]
• Protein Sequence: MASGSGFLGQISSMEEADFAEKDPSGRYIRYDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSALLASSSTSSKYVRPPQLEHLPMDVDHNENKSVSSNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLLSDRTSSHHNQNSPRLTHEDHEAANQQTVNSKDEEAAGQSMKSDISADYYFPYSANDGNAAMEAGRDAESMSSYLDSCSMMSTIYNLSISDNDYPEDLKTELNLIESQFNQSFQDLLKLKEDAIENAKRKWITKKQKAVNIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
326	Phosphorylation	VDHNENKSVSSNEDY CCCCCCCCCCCCCCC	38.52	30407730
328	Phosphorylation	HNENKSVSSNEDYPW CCCCCCCCCCCCCCH	34.24	30407730
329	Phosphorylation	NENKSVSSNEDYPWS CCCCCCCCCCCCCHH	41.92	30407730
333	Phosphorylation	SVSSNEDYPWSQTIE CCCCCCCCCHHHEEE	10.62	30407730
336	Phosphorylation	SNEDYPWSQTIELQR CCCCCCHHHEEEHHH	16.97	30407730
509	Phosphorylation	MSTIYNLSISDNDYP HHHHHHCCCCCCCCC	19.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNK8_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNK8_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WNK8_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EMF1_ARATH	EMF1	physical	21700722
GPLPC_ARATH	RACK1C_AT	physical	25489024
WNK8_ARATH	WNK8	physical	16427632
VATC_ARATH	DET3	physical	16427632

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.