CAS_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAS_ARATH
• UniProt AC: Q9FN48
• Protein Name: Calcium sensing receptor, chloroplastic
• Gene Name: CAS
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 387
• Subcellular Localization: Plastid, chloroplast thylakoid membrane ; Single-pass membrane protein ; Stromal side .
• Protein Description: Modulates cytoplasmic Ca(2+) concentration and is crucial for proper stomatal regulation in response to elevated levels of external Ca(2+). May function by regulating concentrations of inositol 1,4,5-trisphosphate (IP3), which in turn triggers release of Ca(2+) from internal stores. May play a role in de-etiolation..
• Protein Sequence: MAMAEMATKSSLSAKLTLPSSSTKKTLSLRQVSVSLPTSTSISLLSLFASPPHEAKAAVSIPKDQIVSSLTEVEKTINQVQETGSSVFDATQRVFQVVGDALKPALDTALPIAKQAGEEAMKLASPAFSEASKKAQEAMQSSGFDSEPVFNAAKTVTDVAQQTSKAIEDAKPIASSTMDTISSADPSVIVVAAGAAFLAYLLLPPVFSAISFNFRGYKGDLTPAQTLDLLCTKNYLMVDIRSEKDKEKAGIPRLPSNAKNRVISIPLEELPNKVKGIVRNSKRVEAEIAALKISYLKKINKGSNIIILDSYTDSAKIVAKTLKVLGYKNCYIVTDGFSGGRGWLQSRLGTDSYNFSFAQVLSPSRIIPAASRSFGTRSGTKFLPSSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	SLTEVEKTINQVQET HHHHHHHHHHHHHHH	16.20	29797451
264	Phosphorylation	NAKNRVISIPLEELP CCCCCEEEEEHHHCC	18.46	19880383
350	Phosphorylation	WLQSRLGTDSYNFSF HHHHHHCCCCCCEEH	26.77	19376835
352	Phosphorylation	QSRLGTDSYNFSFAQ HHHHCCCCCCEEHHH	23.09	19376835
353	Phosphorylation	SRLGTDSYNFSFAQV HHHCCCCCCEEHHHH	24.04	19376835
356	Phosphorylation	GTDSYNFSFAQVLSP CCCCCCEEHHHHCCH	18.94	30291188
362	Phosphorylation	FSFAQVLSPSRIIPA EEHHHHCCHHHEEEH	23.21	19376835
364	Phosphorylation	FAQVLSPSRIIPAAS HHHHCCHHHEEEHHH	32.51	19376835
371	Phosphorylation	SRIIPAASRSFGTRS HHEEEHHHHCCCCCC	30.48	19376835
373	Phosphorylation	IIPAASRSFGTRSGT EEEHHHHCCCCCCCC	26.07	19376835
376	Phosphorylation	AASRSFGTRSGTKFL HHHHCCCCCCCCCCC	21.46	19376835
378	Phosphorylation	SRSFGTRSGTKFLPS HHCCCCCCCCCCCCC	51.13	23111157
380	Phosphorylation	SFGTRSGTKFLPSSD CCCCCCCCCCCCCCC	21.62	30291188
385	Phosphorylation	SGTKFLPSSD----- CCCCCCCCCC-----	49.65	27545962
386	Phosphorylation	GTKFLPSSD------ CCCCCCCCC------	45.45	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAS_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAS_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAS_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of CAS_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373; SER-378 ANDTHR-380, AND IDENTIFICATION BY MASS SPECTROMETRY.
PubMed: 19376835

"Light regulation of CaS, a novel phosphoprotein in the thylakoidmembrane of Arabidopsis thaliana.";
Vainonen J.P., Sakuragi Y., Stael S., Tikkanen M., Allahverdiyeva Y.,Paakkarinen V., Aro E., Suorsa M., Scheller H.V., Vener A.V.,Aro E.M.;
FEBS J. 275:1767-1777(2008).
Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-380, AND DISRUPTIONPHENOTYPE.
PubMed: 18331354