GCR1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCR1_ARATH
• UniProt AC: O04714
• Protein Name: G-protein coupled receptor 1
• Gene Name: GCR1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 326
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Localized to the outer edge of the leaf epidermal cells in a punctuate pattern.
• Protein Description: Together with GPA1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate(IP(3)) as a second messenger. Acts as a negative regulator of GPA1-mediated abscisic acid (ABA) responses in guard cells, and together with GPA1 and GB1 during seed germination and early seedling development. Promotes PI-PLC activity and IP(3) accumulation. Involved in the blue light (BL) signaling. Together with GPA1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings. Probably involved in cytokinin signal transduction. Plays a positive role in gibberellin- (GA) and brassinosteroid- (BR) regulated seed germination, probably independently of a heterotrimeric G-protein. Mediates seed dormancy abolition, and promotes seed germination and flowering..
• Protein Sequence: MSAVLTAGGGLTAGDRSIITAINTGASSLSFVGSAFIVLCYCLFKELRKFSFKLVFYLALSDMLCSFFLIVGDPSKGFICYAQGYTTHFFCVASFLWTTTIAFTLHRTVVKHKTDVEDLEAMFHLYVWGTSLVVTVIRSFGNNHSHLGPWCWTQTGLKGKAVHFLTFYAPLWGAILYNGFTYFQVIRMLRNARRMAVGMSDRVDQFDNRAELKVLNRWGYYPLILIGSWAFGTINRIHDFIEPGHKIFWLSVLDVGTAALMGLFNSIAYGFNSSVRRAIHERLELFLPERLYRWLPSNFRPKNHLILHQQQQQRSEMVSLKTEDQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAVLTAGG ------CCCEEECCC	27.38	22223895
51	Phosphorylation	FKELRKFSFKLVFYL HHHHHHCHHHHHHHH	25.22	19880383
143	N-linked_Glycosylation	VIRSFGNNHSHLGPW HHHHHCCCCCCCCCE	38.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCR1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCR1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCR1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GPA1_ARATH	GP ALPHA 1	physical	15155892
NAC89_ARATH	NAC089	physical	21798944
PLST4_ARATH	PGLCT	physical	22737156
PTR2_ARATH	PTR2	physical	22737156

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.