MIS4_SCHPO - dbPTM
MIS4_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MIS4_SCHPO
UniProt AC Q09725
Protein Name Sister chromatid cohesion protein mis4
Gene Name mis4
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1587
Subcellular Localization Nucleus. Chromosome. Associates with chromosomes in a punctate fashion throughout the cell cycle.
Protein Description Plays a structural role in chromatin. Chromatid cohesion molecule required for equal sister chromatid separation in anaphase. May form a stable link between chromatids in S phase that is split rather than removed in anaphase. Also required for spindle-kinetochore interaction in early mitosis and inhibit sister chromatid separation until the cleavage of Rad21 in anaphase..
Protein Sequence MLFEMTPETFKKVNSSNRIIKGLQYTPLASSIPLENGLQNVLYPSSKFQNEPLQLNSEESSIMQRYVDMLNPGATFVNDSETFNFYKNALSAMITEPAMPAMRVNASPVLDQKVCNSDSLSELNDFTKSLIQPSMLMCEPKEKPDASSINTNRSSSDNGFLTPSSSPRSPSCSRVFNAVQLCSPKKSKDDITTPKKRLMEDTYSPRESPSKIQRLQDVLLKQLQDTRLLISQVIEAENSEDFSSNSLFIKREDDDGKHISSHAIEKLYMALTKLSRLGACDKLLEEGSIILVKQILEKELKELPVACYSIINLHDSLTQFPNLDFILKTTALVLFIIFLVPSFKKLQNEESILHLLNILHSIFEYTVPEAIDNIVQSKTSDARTSEIQHLSVLLQKVANVLNILSKVAHEIPLSEAVVIRIVYLFPKVSTLDNSFKTKLPNCNSSSFDFLKAPLFQTLQYLFRLYPYQRDFIIEESLTNFSHLPTARSVSRTYRLSNGKSIQYYSTLFVRLIQSCSIQNLFDSEIVQSESKSTEALHSGNLTEHLKTVESILSKSRHEEYRIANHIVAYLLSRSLKQNKTESDNSFAILTKILLEDLLNMLSLPEWCGTETIIRQFAMNLVMTVTNDKQAVSSKNAALDLISLIVNKVLALFDLSLFEKHNIPAPTNFNDIISFIPSITRLNELSQVSFNHFYFLCKGDISLENILPYNYNKWFSFLLQLRKVCNDSEALKIIDNCIDKNMQKSQEGFQGPSPFKADENDEDIFIISLYHSSLFLNLKFFVSLIIGFLDSPQASLRTKCLRIINQMKTIPSILRTHPEVLAQIISKSNDQSAIVRDTVLDLLGTYIMAYRETIPQIYGCIISGISDPSTIVRKRAIKQLCEVYEATEDLNIRVDIASKLLTRSNDEEETISELSLEVLEKLWFSPASNELDCQKGYEQLTFLEKQKLRVQYFPILKLCAEPSTERHVLLVTSLKTMLTSKEEINLSTLHTQIRLLLSCLFNQLIEVVTEDQVDESTKGILYEIMSTLFVFSRAFPFLFDLSYLHLLKPYLRSASTIEEQRFLYYVVAIFRQVLPFQKEISESFLRSLESVLLQRLTKAGTATLMEIVPCLCSLFTRLNDYERLKKIVVSCLKSLEEARHSENNFQKMVRLIDLIGLFSRYGDLNRINDDWKHSLDFISPECDDAYVILLGYFQKLLKDAKGQLRIHIIDNMSRICLRETSLFISPLMLSTLDMIIAENNVNEVSVLFKSFLELLAADEDLIFEADQKLSLKGKQNVQSNKSVDRDMLKGTKDKQWIEGVSASLMQHFLPCILDSCFSKNLRYSMLGIEILKCIIHQGLVNPRMCFSTIIALESNAIKETREVAILLHTELHRRHESLIDGLYAQSADLIFSLQKTEEYQTFKLGEFSPFQSAYTIVSADKSSKSRKKLIMQILKPLKLDGIDLPSFTEEKVSFVSFCCVCLAGIPYVSIEEPLMIISTVDSVLATIGPTITGWMKKLDHERFKILAGINLCNLIYLKRYIKYAFSISDSSRPIREKKPLTLLNRGYVDLITSDAKPDIVSKLVIKLFEEENILSGEDQVEGEQLTVV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
107PhosphorylationPAMRVNASPVLDQKV
CCCCCCCCCCCCCCC		15.4429996109
162PhosphorylationSSDNGFLTPSSSPRS
CCCCCCCCCCCCCCC		20.9025720772
164PhosphorylationDNGFLTPSSSPRSPS
CCCCCCCCCCCCCCC		37.9125720772
166PhosphorylationGFLTPSSSPRSPSCS
CCCCCCCCCCCCCHH		28.7725720772
169PhosphorylationTPSSSPRSPSCSRVF
CCCCCCCCCCHHHHH		25.2525720772
183PhosphorylationFNAVQLCSPKKSKDD
HHHHHHCCCCCCCCC		48.6328889911
193PhosphorylationKSKDDITTPKKRLME
CCCCCCCCCHHHHHC		33.1827738172
202PhosphorylationKKRLMEDTYSPRESP
HHHHHCCCCCCCCCH		16.7629996109
203PhosphorylationKRLMEDTYSPRESPS
HHHHCCCCCCCCCHH		29.0621712547
204PhosphorylationRLMEDTYSPRESPSK
HHHCCCCCCCCCHHH		21.4124763107
208PhosphorylationDTYSPRESPSKIQRL
CCCCCCCCHHHHHHH		35.4324763107
210PhosphorylationYSPRESPSKIQRLQD
CCCCCCHHHHHHHHH		52.2321712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MIS4_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MIS4_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MIS4_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DNLI1_SCHPOcdc17genetic
9808627
MAD2_SCHPOmad2genetic
11882285
SCC4_SCHPOssl3physical
16682348
RAD21_SCHPOrad21physical
16682348
PDS5_SCHPOpds5genetic
11598020
SWI6_SCHPOswi6genetic
21189291
RAD21_SCHPOrad21genetic
21189291
RAD1_SCHPOrad1genetic
23050226
HUS1_SCHPOhus1genetic
23050226
RAD9_SCHPOrad9genetic
23050226
PST2_SCHPOpst2genetic
23050226
SWI6_SCHPOswi6genetic
23050226
CLR3_SCHPOclr3genetic
23050226
JHD1_SCHPOepe1genetic
23050226
RAF2_SCHPOraf2genetic
23050226
PDS5_SCHPOpds5genetic
23050226
RHP41_SCHPOrhp41genetic
23050226
NAB2_SCHPOnab2genetic
23050226
FUB1_SCHPOSPAC15E1.10genetic
23050226
DUS3_SCHPOdus3genetic
23050226
PPK4_SCHPOire1genetic
23050226
RL28E_SCHPOrpl44genetic
23050226
MDE1_SCHPOmde1genetic
23050226
YIN2_SCHPOSPAC1705.02genetic
23050226
PHB1_SCHPOphb1genetic
23050226
PLPL_SCHPOptl2genetic
23050226
YDFF_SCHPOSPAC17C9.15cgenetic
23050226
PEX7_SCHPOpex7genetic
23050226
YEO3_SCHPOSPAC17G6.03genetic
23050226
CID16_SCHPOcid16genetic
23050226
DAD2_SCHPOdad2genetic
23050226
MAL3_SCHPOmal3genetic
23050226
CTF8_SCHPOctf8genetic
23050226
YDA4_SCHPOSPAC1F12.04cgenetic
23050226
YK96_SCHPOSPAC20H4.06cgenetic
23050226
YDBJ_SCHPOsnt1genetic
23050226
RL16A_SCHPOrpl1602genetic
23050226
PDP3_SCHPOpdp3genetic
23050226
PPK9_SCHPOppk9genetic
23050226
FFT3_SCHPOfft3genetic
23050226
YEG5_SCHPOmga2genetic
23050226
ETFA_SCHPOetf1genetic
23050226
YEI1_SCHPOSPAC27E2.01genetic
23050226
SEC72_SCHPOSPAC2F3.02genetic
23050226
PEX13_SCHPOpex13genetic
23050226
FEN1_SCHPOrad2genetic
23050226
SNT2_SCHPOsnt2genetic
23050226
DIL1_SCHPOdli1genetic
23050226
ISP6_SCHPOisp6genetic
23050226
MET8_SCHPOSPAC4D7.06cgenetic
23050226
DNPEP_SCHPOaap1genetic
23050226
DID4_SCHPOdid4genetic
23050226
YAY6_SCHPOSPAC4H3.06genetic
23050226
YFE3_SCHPOSPAC637.03genetic
23050226
SEN1_SCHPOsen1genetic
23050226
YETB_SCHPOfra2genetic
23050226
RAD24_SCHPOrad24genetic
23050226
YF15_SCHPOSPAC9E9.05genetic
23050226
YKM7_SCHPOSPAPB24D3.07cgenetic
23050226
RL3B_SCHPOrpl302genetic
23050226
YIPL_SCHPOSPAPJ691.02genetic
23050226
AMPD_SCHPOada1genetic
23050226
PTR2_SCHPOptr2genetic
23050226
KLP9_SCHPOklp9genetic
23050226
YBE3_SCHPOSPBC17D11.03cgenetic
23050226
YGL1_SCHPOpsy2genetic
23050226
YOX1_SCHPOyox1genetic
23050226
LTN1_SCHPOrkr1genetic
23050226
YG41_SCHPOcxr1genetic
23050226
RLA4_SCHPOrpp202genetic
23050226
EXO1_SCHPOexo1genetic
23050226
PDP1_SCHPOpdp1genetic
23050226
WSC1_SCHPOwsc1genetic
23050226
SWI3_SCHPOswi3genetic
23050226
MUB1_SCHPOSPBC31F10.10cgenetic
23050226
PAN3_SCHPOppk26genetic
23050226
ERG28_SCHPOerg28genetic
23050226
YGR8_SCHPOSPBC365.08cgenetic
23050226
LYS9_SCHPOSPBC3B8.03genetic
23050226
NEM1_SCHPOnem1genetic
23050226
MTXL_SCHPOSPBC409.19cgenetic
23050226
PPA2_SCHPOpho4genetic
23050226
PTEN_SCHPOptn1genetic
23050226
OFD1_SCHPOofd1genetic
23050226
WHI5_SCHPOwhi5genetic
23050226
YG1B_SCHPOpet2genetic
23050226
HPC2_SCHPOhip4genetic
23050226
YCDA_SCHPOSPCC1322.10genetic
23050226
RL19B_SCHPOrpl1902genetic
23050226
YQJ9_SCHPOSPCC1840.09genetic
23050226
YJX4_SCHPOSPCC23B6.04cgenetic
23050226
POF3_SCHPOpof3genetic
23050226
CBF11_SCHPOcbf11genetic
23050226
MUG24_SCHPOmug24genetic
23050226
RNC1_SCHPOrnc1genetic
23050226
ELP2_SCHPOelp2genetic
23050226
YQMA_SCHPOSPCP1E11.10genetic
23050226
TRMB_SCHPOtrm8genetic
23050226
CLR3_SCHPOclr3genetic
18354085
PHD1_SCHPOhos2genetic
18354085
SMC1_SCHPOpsm1physical
26687354
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MIS4_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, AND MASSSPECTROMETRY.

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