dbPTM

PDP3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PDP3_SCHPO
UniProt AC	Q09842
Protein Name	PWWP domain-containing protein 3
Gene Name	pdp3
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	407
Subcellular Localization	Nucleus .
Protein Description	Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation..
Protein Sequence	MMVARTRSQKRKLEEINNQKKIKTKKKATGQQTSNTKNLRDVKKKGKQLAYVPRTSPRKSYKNGEYVLAKMSSFPWWPARVASQKSIPTEVRERLKRNFRMDNGIFVQFLPSRDYAIISSSNVLPLTVDESRFILDHDLSTKYIQKTVGLIIASVKRKVSFSDVEEDEFEPENTRKKLQKPIEKPKKEKIEATPKIDGGKRLKNEKSSAEISQTSKQRPSRRSARVRMATDNAQKSPSPIPSPKKTAKKRVRFAGSLEELPKFSLEYQLAQPISTVDMYAQVHYIRFNTLLYYRYQLQEILLSYNHYPQESDMSHVHQILEMIENFSAINSELLESTKLYSLFTLLVKLSDIPLDEKYDFSSRFSTLLLQFQAFVQPKTMTSNVSTAPIGKNAQVNTEAARPSVITT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	KSYKNGEYVLAKMSS CCCCCCCEEEEECCC	11.36	25720772
83	Phosphorylation	WWPARVASQKSIPTE CCHHHHHCCCCCCHH	34.97	25720772
160	Phosphorylation	ASVKRKVSFSDVEED HHCCCCCCCCCCCCC	23.28	28889911
162	Phosphorylation	VKRKVSFSDVEEDEF CCCCCCCCCCCCCCC	32.99	28889911
236	Phosphorylation	ATDNAQKSPSPIPSP HCCCCCCCCCCCCCC	20.66	28889911
238	Phosphorylation	DNAQKSPSPIPSPKK CCCCCCCCCCCCCCC	42.42	28889911
242	Phosphorylation	KSPSPIPSPKKTAKK CCCCCCCCCCCCHHH	50.50	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PDP3_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PDP3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PDP3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NTO1_SCHPO	nto1	physical	22184112
MST2_SCHPO	mst2	physical	22184112
TAF14_SCHPO	tfg3	physical	22184112
PTF1_SCHPO	ptf1	physical	22184112
EAF6_SCHPO	eaf6	physical	22184112
PTF2_SCHPO	ptf2	physical	22184112

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PDP3_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160; SER-162; SER-236;SER-238 AND SER-242, AND MASS SPECTROMETRY.	18257517 [Abstract]