TM171_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM171_HUMAN
• UniProt AC: Q8WVE6
• Protein Name: Transmembrane protein 171
• Gene Name: TMEM171
• Organism: Homo sapiens (Human).
• Sequence Length: 324
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MSPAAAAEPDGDQQDRHVSKLIFCFFVFGAVLLCVGVLLSIFGFQACQYKPLPDCPMVLKVAGPACAVVGLGAVILARSRAQLQLRAGLQRGQQMDPDRAFICGESRQFAQCLIFGFLFLTSGMLISVLGIWVPGCGSNWAQEPLNETDTGDSEPRMCGFLSLQIMGPLIVLVGLCFFVVAHVKKRNTLNAGQDASEREEGQIQIMEPVQVTVGDSVIIFPPPPPPYFPESSASAVAESPGTNSLLPNENPPSYYSIFNYGRTPTSEGAASERDCESIYTISGTNSSSEASHTPHLPSELPPRYEEKENAAATFLPLSSEPSPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
196	Phosphorylation	LNAGQDASEREEGQI CCCCCCHHHCCCCCE	45.54	28509920
266	O-linked_Glycosylation	NYGRTPTSEGAASER CCCCCCCCCCCCCHH	34.92	30620550
279	Phosphorylation	ERDCESIYTISGTNS HHCCCEEEEEECCCC	13.80	27642862
288	Ubiquitination	ISGTNSSSEASHTPH EECCCCCCCCCCCCC	36.68	22817900
306	Ubiquitination	ELPPRYEEKENAAAT CCCCCHHHHCCCCCC	57.65	22817900
306 (in isoform 2)	Ubiquitination	-	57.65	21906983
307	Ubiquitination	LPPRYEEKENAAATF CCCCHHHHCCCCCCC	44.31	22817900
307 (in isoform 1)	Ubiquitination	-	44.31	21906983
313	Phosphorylation	EKENAAATFLPLSSE HHCCCCCCCCCCCCC	22.45	-
319	Phosphorylation	ATFLPLSSEPSPP-- CCCCCCCCCCCCC--	62.30	-
322	Phosphorylation	LPLSSEPSPP----- CCCCCCCCCC-----	45.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM171_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM171_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM171_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHAP1_HUMAN	CHAMP1	physical	26186194
NEDD4_HUMAN	NEDD4	physical	26186194
ITCH_HUMAN	ITCH	physical	26186194
NED4L_HUMAN	NEDD4L	physical	26186194
INT5_HUMAN	INTS5	physical	26186194
GPC5B_HUMAN	GPRC5B	physical	26186194
GPC5C_HUMAN	GPRC5C	physical	26186194
VPS45_HUMAN	VPS45	physical	26186194
HEAT3_HUMAN	HEATR3	physical	26186194
SNAA_HUMAN	NAPA	physical	26186194
STX4_HUMAN	STX4	physical	26186194
CKAP2_HUMAN	CKAP2	physical	26186194
HIP1R_HUMAN	HIP1R	physical	26186194
XPO2_HUMAN	CSE1L	physical	26186194
TTYH3_HUMAN	TTYH3	physical	26186194
ORC5_HUMAN	ORC5	physical	26186194
VIGLN_HUMAN	HDLBP	physical	26186194
STXB4_HUMAN	STXBP4	physical	26186194
MCM10_HUMAN	MCM10	physical	26186194
ERD23_HUMAN	KDELR3	physical	26186194
STX5_HUMAN	STX5	physical	26186194
BIG2_HUMAN	ARFGEF2	physical	26186194
WWOX_HUMAN	WWOX	physical	26186194
TM186_HUMAN	TMEM186	physical	26186194
GHITM_HUMAN	GHITM	physical	26186194
SCMC1_HUMAN	SLC25A24	physical	26186194
CD97_HUMAN	CD97	physical	26186194
TNPO3_HUMAN	TNPO3	physical	26186194
ALG6_HUMAN	ALG6	physical	26186194
CTR2_HUMAN	SLC7A2	physical	26186194
EMSY_HUMAN	C11orf30	physical	26186194
MSPD2_HUMAN	MOSPD2	physical	26186194
PAQR1_HUMAN	ADIPOR1	physical	26186194
STX8_HUMAN	STX8	physical	26186194
MAN1_HUMAN	LEMD3	physical	26186194
ABCB8_HUMAN	ABCB8	physical	26186194
HELLS_HUMAN	HELLS	physical	26186194
OSBL8_HUMAN	OSBPL8	physical	26186194
CHPT1_HUMAN	CHPT1	physical	26186194
KNTC1_HUMAN	KNTC1	physical	26186194
POGZ_HUMAN	POGZ	physical	26186194
MTX1_HUMAN	MTX1	physical	26186194
RFT1_HUMAN	RFT1	physical	26186194
DGLB_HUMAN	DAGLB	physical	26186194
TPC1_HUMAN	TPCN1	physical	26186194
OCLN_HUMAN	OCLN	physical	26186194
P52K_HUMAN	PRKRIR	physical	26186194
SYMPK_HUMAN	SYMPK	physical	26186194
SNAPN_HUMAN	SNAPIN	physical	26186194
MTX3_HUMAN	MTX3	physical	26186194
MTR1L_HUMAN	GPR50	physical	26186194
CKLF4_HUMAN	CMTM4	physical	26186194
CHAP1_HUMAN	CHAMP1	physical	28514442
WWOX_HUMAN	WWOX	physical	28514442
MCM10_HUMAN	MCM10	physical	28514442
NED4L_HUMAN	NEDD4L	physical	28514442
TPC1_HUMAN	TPCN1	physical	28514442
STXB4_HUMAN	STXBP4	physical	28514442
GPC5B_HUMAN	GPRC5B	physical	28514442
VIGLN_HUMAN	HDLBP	physical	28514442
NEDD4_HUMAN	NEDD4	physical	28514442
SCMC1_HUMAN	SLC25A24	physical	28514442
MTR1L_HUMAN	GPR50	physical	28514442
DGLB_HUMAN	DAGLB	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
EMSY_HUMAN	C11orf30	physical	28514442
MSPD2_HUMAN	MOSPD2	physical	28514442
CKLF4_HUMAN	CMTM4	physical	28514442
POGZ_HUMAN	POGZ	physical	28514442
CD97_HUMAN	CD97	physical	28514442
MTX3_HUMAN	MTX3	physical	28514442
TSN3_HUMAN	TSPAN3	physical	28514442
ORC5_HUMAN	ORC5	physical	28514442
GPC5C_HUMAN	GPRC5C	physical	28514442
CHPT1_HUMAN	CHPT1	physical	28514442
ITCH_HUMAN	ITCH	physical	28514442
PAQR1_HUMAN	ADIPOR1	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442
ABCB8_HUMAN	ABCB8	physical	28514442
CKAP2_HUMAN	CKAP2	physical	28514442
SNAPN_HUMAN	SNAPIN	physical	28514442
ERD23_HUMAN	KDELR3	physical	28514442
CXCR4_HUMAN	CXCR4	physical	28514442
HELLS_HUMAN	HELLS	physical	28514442
INT5_HUMAN	INTS5	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
P52K_HUMAN	PRKRIR	physical	28514442
STX8_HUMAN	STX8	physical	28514442
STX5_HUMAN	STX5	physical	28514442
MPC2_HUMAN	MPC2	physical	28514442
KNTC1_HUMAN	KNTC1	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442
TTYH3_HUMAN	TTYH3	physical	28514442
DOLK_HUMAN	DOLK	physical	28514442
NFRKB_HUMAN	NFRKB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.