LET60_CAEEL - dbPTM
LET60_CAEEL - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LET60_CAEEL
UniProt AC P22981
Protein Name Ras protein let-60
Gene Name let-60
Organism Caenorhabditis elegans.
Sequence Length 184
Subcellular Localization Cell membrane
Lipid-anchor.
Protein Description The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. [PubMed: 2257629]
Protein Sequence MTEYKLVVVGDGGVGKSALTIQLIQNHFVEEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNEAKSFENVANYREQIRRVKDSDDVPMVLVGNKCDLSSRSVDFRTVSETAKGYGIPNVDTSAKTRMGVDEAFYTLVREIRKHRERHDNNKPQKKKKCQIM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
181MethylationKPQKKKKCQIM----
CCCCCCCCCCC----
4.56-
181FarnesylationKPQKKKKCQIM----
CCCCCCCCCCC----
4.56-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LET60_CAEEL !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LET60_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LET60_CAEEL !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BTF3_CAEELicd-1physical
14704431
SHOC2_CAEELsoc-2genetic
17897480
DHX16_CAEELmog-4genetic
17897480
LE756_CAEELlet-756genetic
17897480
PDI2_CAEELpdi-2genetic
17897480
CGH1_CAEELcgh-1genetic
17897480
LIN39_CAEELlin-39genetic
17897480
ROCK_CAEELlet-502genetic
17897480
RO60_CAEELrop-1genetic
17897480
SEM5_CAEELsem-5genetic
17897480
TRA2_CAEELtra-2genetic
17897480
ROL3_CAEELrol-3genetic
17897480
LAG3_CAEELsel-8genetic
17897480
SMA6_CAEELsma-6genetic
17897480
CCNE_CAEELcye-1genetic
17897480
PAL1_CAEELpal-1genetic
17897480
HDA1_CAEELhda-1genetic
17897480
LAM2_CAEELlam-2genetic
17897480
BAR1_CAEELbar-1genetic
17897480
BTF3_CAEELicd-1genetic
17897480
MOG5_CAEELmog-5genetic
17897480
ZYG9_CAEELzyg-9genetic
17897480
LRP_CAEELlrp-1genetic
17897480
ITPR_CAEELitr-1genetic
17897480
LIN3_CAEELlin-3genetic
17897480
PHA4_CAEELpha-4genetic
17897480
MOM2_CAEELmom-2genetic
17897480
MED23_CAEELsur-2genetic
17897480
UNC6_CAEELunc-6genetic
17897480
MPK1_CAEELmpk-1genetic
17897480
UNC53_CAEELunc-53genetic
17897480
DPY7_CAEELdpy-7genetic
17897480
MED12_CAEELdpy-22genetic
17897480
HMG12_CAEELhmg-1.2genetic
17897480
LIN25_CAEELlin-25genetic
17897480
MEI2_CAEELmei-2genetic
17897480
HMP2_CAEELhmp-2genetic
17897480
MPIP1_CAEELcdc-25.1genetic
17897480
MUP4_CAEELmup-4genetic
17897480
EPI1_CAEELepi-1genetic
17897480
MUA3_CAEELmua-3genetic
17897480
SUMO_CAEELsmo-1genetic
17897480
PROS1_CAEELpros-1genetic
17897480
14331_CAEELpar-5genetic
17897480
SPT6H_CAEELemb-5genetic
17897480
DPY2_CAEELdpy-2genetic
17897480
DPY10_CAEELdpy-10genetic
17897480
GLH1_CAEELglh-1genetic
17897480
GLD1_CAEELgld-1genetic
17897480
PAR6_CAEELpar-6genetic
17897480
UNC62_CAEELunc-62genetic
17897480
APH1_CAEELaph-1genetic
17897480
MEX5_CAEELmex-5genetic
17897480
TMED2_CAEELsel-9genetic
17897480
POP1_CAEELpop-1genetic
17897480
GSK3_CAEELgsk-3genetic
17897480
CHK1_CAEELchk-1genetic
17897480
PIE1_CAEELpie-1genetic
17897480
VPS28_CAEELvps-28genetic
17897480
UNC52_CAEELunc-52genetic
17897480
PAT3_CAEELpat-3genetic
17897480
YWIE_CAEELZK546.14genetic
17897480
MED1_CAEELsop-3genetic
16845399
EGL27_CAEELegl-27genetic
16845399
H11_CAEELhis-24genetic
16845399
ILA2_CAEELins-22genetic
16845399
NHR44_CAEELnhr-44genetic
16845399
LAR_CAEELptp-3genetic
16845399

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LET60_CAEEL

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Related Literatures of Post-Translational Modification

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