EGL27_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EGL27_CAEEL
• UniProt AC: Q09228
• Protein Name: Egg-laying defective protein 27
• Gene Name: egl-27
• Organism: Caenorhabditis elegans.
• Sequence Length: 1129
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor which promotes stress survival and delays aging. Required for normal T-cell polarity, for correct migration of QL neuroblast descendants and other cells, for embryonic patterning and for the embryonic expression of hlh-8. Also required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development..
• Protein Sequence: MSRFDSQCSSEDVNKEDECVPSSSEDSQDGVSSPMENDDEPEFSQKHYDIEPCYYSLTGKSDRNCRGIVYRYRQDSDLKGFQSHDGTLYRLRDSVFVEVSQNEPYVIAAICGFKYTKRDHVVVKLTRYFRADDIPEISLNLMKQERAELEINPHLCPQSLNRELFNSELQITQPVSCLRGKCIVEYVKDVRHARTVADFSLDNDTFFFCLHYNQDSTKLASTHYAIRVGTSFQATLPPMAECSVGDDSDRDELLYRPNSIESGEEEDYIKLARCYRTYTLSGNHMLDSQKNARSLQVSDLLMDEAIIQLHRSGYKIDDALSELNANDIILTTDVDNMTQDDAKKFAKGIKQLGKNFSRIHRELLPHHSREQLVSYYYLWKKTPEATKPKQAARRVNPTSIKRPTKEKVKASRPTSTEYLDFDSASESDVENNGPSGRACHHCYGAESKDWHHANGLLLCTDCRLHYKKYGQLRQIANRPSQVPACLFKRSNSDEEESGVRTRAGKKEQRRRTPSSMSETPDRRSPSTVSNGAPNLTAEETPTKKLNGSVKRAPKRPLHNGVINNVEKSNSSEEPASPTTPPPTLTNGLTNGHGPESSTPNGETISKRMKVEPSYDDDDDEEEGKMTIDEGDDDPMPVLNGFKKEESVEEIKLELNGTIKKENGVETDPTTPTCSMEAENEVCETPAVVSVEIRDETNGETNSDLKDDENVEPDSPEDTFELGSNVEFETKNAMFVRSIVRSCGPRCARTDLIFKIKVGGVWEKSIKEKEERKKVHLQNQRIQDSEKVAIQQNQIKKEQQQSQPTPQQIHQQQAQQNAQHLQQLQQAVMLGHLPPEVLRQMMPPQFGVDPTAILMQQMMAGQQSQGVNAAFQHQMALQQQLEAHQVQFQLMMAHQHQQKMIAEQQQQQRHAAAQQLREREQREQRERERERQHQQQAQQALHQQQQQHAAAAANQLNPAMMQMMALMANSAASQQDIARLMEMAAQQQQQQQQAAQAQAQRDQERERREREAREREAAREREREQAAREAAARDQAAREHAQAVQAAAAAAQQAQALTPDMQHMHLLQQLMLNPALMMQLQQAQAQQQQQQPQVTNPLQMLQHGMAAQSANQAEMMRRIHPEPAMRPQHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
492	Phosphorylation	CLFKRSNSDEEESGV EEEECCCCCHHHHCC	47.87	30078680
524	Phosphorylation	SETPDRRSPSTVSNG CCCCCCCCCCCCCCC	24.89	28854356
526	Phosphorylation	TPDRRSPSTVSNGAP CCCCCCCCCCCCCCC	42.56	19530675
536	Phosphorylation	SNGAPNLTAEETPTK CCCCCCCCCCCCCCC	38.37	19530675
540	Phosphorylation	PNLTAEETPTKKLNG CCCCCCCCCCCCCCC	27.97	19530675
542	Phosphorylation	LTAEETPTKKLNGSV CCCCCCCCCCCCCCC	48.51	19530675
646	Phosphorylation	NGFKKEESVEEIKLE CCCCCCCCHHHHHHE	35.60	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EGL27_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EGL27_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EGL27_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEP1_CAEEL	mep-1	physical	25567989

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.