MEP1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEP1_CAEEL
• UniProt AC: Q21502
• Protein Name: MOG interacting and ectopic P-granules protein 1
• Gene Name: mep-1 {ECO:0000312|WormBase:M04B2.1}
• Organism: Caenorhabditis elegans.
• Sequence Length: 870
• Subcellular Localization: Nucleus . Found in all nuclei in the germline, including oocytes, but not those of mature sperm and spermatocytes.
• Protein Description: Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR..
• Protein Sequence: MVTADETVLATTTNTTSMSVEPTDPRSAGESSSDSEPDTIEQLKAEQREVMADAANGSEVNGNQENGKEEAASADVEVIEIDDTEESTDPSPDGSDENGDAASTSVPIEEEARKKDEGASEVTVASSEIEQDDDGDVMEITEEPNGKSEDTANGTVTEEVLDEEEPEPSVNGTTEIATEKEPEDSSMPVEQNGKGVKRPVECIELDDDDDDEIQEISTPAPAKKAKIDDVKATSVPEEDNNEQAQKRLLDKLEEYVKEQKDQPSSKSRKVLDTLLGAINAQVQKEPLSVRKLILDKVLVLPNTISFPPSQVCDLLIEHDPEMPLTKVINRMFGEERPKLSDSEKRERAQLKQHNPVPNMTKLLVDIGQDLVQEATYCDIVHAKNLPEVPKNLETYKQVAAQLKPVWETLKRKNEPYKLKMHRCDVCGFQTESKLVMSTHKENLHFTGSKFQCTMCKETDTSEQRMKDHYFETHLVIAKSEEKESKYPCAICEEDFNFKGVREQHYKQCKKDYIRIRNIMMPKQDDHLYINRWLWERPQLDPSILQQQQQAALQQAQQKKQQQLLHQQQAAQAAAAAQLLRKQQLQQQQQQQQARLREQQQAAQFRQVAQLLQQQSAQAQRAQQNQGNVNHNTLIAAMQASLRRGGQQGNSLAVSQLLQKQMAALKSQQGAQQLQAAVNSMRSQNSQKTPTHRSSKLVTTPSHATVGSSSAPTFVCEICDASVQEKEKYLQHLQTTHKQMVGKVLQDMSQGAPLACSRCRDRFWTYEGLERHLVMSHGLVTADLLLKAQKKEDGGRCKTCGKNYAFNMLQHLVADHQVKLCSAEIMYSCDVCAFKCSSYQTLEAHLTSNHPKGDKKTSTPAKKDDCITLDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	DPRSAGESSSDSEPD CCCCCCCCCCCCCCC	33.94	30078680
32	Phosphorylation	PRSAGESSSDSEPDT CCCCCCCCCCCCCCH	33.59	30078680
33	Phosphorylation	RSAGESSSDSEPDTI CCCCCCCCCCCCCHH	55.20	30078680
35	Phosphorylation	AGESSSDSEPDTIEQ CCCCCCCCCCCHHHH	53.64	30078680
39	Phosphorylation	SSDSEPDTIEQLKAE CCCCCCCHHHHHHHH	36.81	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEP1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEP1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEP1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LE418_CAEEL	let-418	physical	12507426
HDA1_CAEEL	hda-1	physical	12507426
PIE1_CAEEL	pie-1	physical	12507426
MEP1_CAEEL	mep-1	physical	12088146
MOG1_CAEEL	mog-1	physical	12088146
DHX16_CAEEL	mog-4	physical	12088146
MOG5_CAEEL	mog-5	physical	12088146

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.