GLH1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLH1_CAEEL
• UniProt AC: P34689
• Protein Name: ATP-dependent RNA helicase glh-1
• Gene Name: glh-1 {ECO:0000312|WormBase:T21G5.3}
• Organism: Caenorhabditis elegans.
• Sequence Length: 763
• Subcellular Localization: Cytoplasm . Cytoplasmic granule . Cytoplasm, perinuclear region . Perinuclear localization in germ cells but disperses into particles in cellularized oocytes. Component of P granules.
• Protein Description: Probable ATP-binding RNA helicase. [PubMed: 8415696 May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos]
• Protein Sequence: MSDGWSDSESAAKAKTGFGSGGGFGGGNNGGSGFGGGKNGGTGFGGGNTGGSGFGGGNTGGSGFGGGKTGGSGFGGGNTCGSGFGGGSTGGSPYGGASSGFGGSTATSGFGSGEKSSAFGGSGGFGGSATGFGSGGGSFGGGNSGFGEGGHGGGERNNNCFNCQQPGHRSSDCPEPRKEREPRVCYNCQQPGHTSRECTEERKPREGRTGGFGGGAGFGNNGGNDGFGGDGGFGGGEERGPMKCFNCKGEGHRSAECPEPPRGCFNCGEQGHRSNECPNPAKPREGVEGEGPKATYVPVEDNMEDVFNMQKISEGLMFNKFFDAEVKLTSSEKTVGIKPCKTFAEANLTETMQKNVAHAGYSKTTPIQQYALPLVHQGYDIMACAQTGSGKTAAFLLPIMTRLIDDNNLNTAGEGGCYPRCIILTPTRELADQIYNEGRKFAYQTMMEIKPVYGGLAVGYNKGQIEKGATIIVGTVGRIKHFCEEGTIKLDKCRFFVLDEADRMIDAMGFGTDIETIVNYDSMPRKENRQTLMFSATFPDSVQEAARAFLRENYVMIAIDKIGAANKCVLQEFERCERSEKKDKLLELLGIDIDSYTTEKSAEVYTKKTMVFVSQRAMADTLASILSSAQVPAITIHGAREQRERSEALRQFRNGSKPVLIATAVAERGLDIKGVDHVINYDMPDNIDDYIHRIGRTGRVGNSGRATSFISEDCSLLSELVGVLADAQQIVPDWMQGAAGGNYGASGFGSSVPTQVPQDEEGW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDGWSDSE ------CCCCCCCHH	44.84	19530675
6	Phosphorylation	--MSDGWSDSESAAK --CCCCCCCHHHHHH	36.47	19530675
8	Phosphorylation	MSDGWSDSESAAKAK CCCCCCCHHHHHHHH	28.12	19530675
10	Phosphorylation	DGWSDSESAAKAKTG CCCCCHHHHHHHHCC	37.16	19530675
16	Phosphorylation	ESAAKAKTGFGSGGG HHHHHHHCCCCCCCC	42.47	19060867
20	Phosphorylation	KAKTGFGSGGGFGGG HHHCCCCCCCCCCCC	31.81	19060867
79	Phosphorylation	SGFGGGNTCGSGFGG CCCCCCCCCCCCCCC	22.86	30078680
82	Phosphorylation	GGGNTCGSGFGGGST CCCCCCCCCCCCCCC	32.85	30078680
88	Phosphorylation	GSGFGGGSTGGSPYG CCCCCCCCCCCCCCC	27.44	30078680
89	Phosphorylation	SGFGGGSTGGSPYGG CCCCCCCCCCCCCCC	49.16	30078680
92	Phosphorylation	GGGSTGGSPYGGASS CCCCCCCCCCCCCCC	19.12	30078680
94	Phosphorylation	GSTGGSPYGGASSGF CCCCCCCCCCCCCCC	29.86	30078680
98	Phosphorylation	GSPYGGASSGFGGST CCCCCCCCCCCCCCC	33.98	30078680
99	Phosphorylation	SPYGGASSGFGGSTA CCCCCCCCCCCCCCC	37.29	30078680
104	Phosphorylation	ASSGFGGSTATSGFG CCCCCCCCCCCCCCC	18.43	30078680
105	Phosphorylation	SSGFGGSTATSGFGS CCCCCCCCCCCCCCC	36.91	30078680
107	Phosphorylation	GFGGSTATSGFGSGE CCCCCCCCCCCCCCC	29.48	30078680
108	Phosphorylation	FGGSTATSGFGSGEK CCCCCCCCCCCCCCC	29.66	30078680
313	Phosphorylation	VFNMQKISEGLMFNK HHCHHHHCCCHHHHH	32.42	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLH1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLH1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLH1_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of GLH1_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.