MED1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED1_CAEEL
• UniProt AC: Q9N4G4
• Protein Name: Mediator of RNA polymerase II transcription subunit 1.1
• Gene Name: sop-3
• Organism: Caenorhabditis elegans.
• Sequence Length: 1475
• Subcellular Localization: Nucleus.
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)..
• Protein Sequence: MIIEERKNHELNLESIDRDLRMENVRQSAEKLGWEHFARSVRRNLLEKRQTLDARTRLDVLGSLVFMKEHLPIDNDATIARKVQQLSEGLGEHCVFSTQNSGFSIRNPDVTIDIGVAEDQISTCKIGYFGQPLTDAPGALALMKNGEFSKLRDSITAILSSLPKEITLSEKNACKEAFRALDQLLIRDAADSSFTAINTGKYGFYAPRNELRSGRIYYVAEPVLIRLAEKEGKTKADASYLDLLPYIEISFFKHDKPSKLPVFTQTGEWSTFNDANVCICVRFNQGFLLSQQTIRKLSHIVPKSPLVRNYVNFYRYMTGRVGVKSNLKLLTQFPDEGDIQQQYQVDSKMLTKEDDVVAMEMYLSDFRDLSKLIETLRSEWKHASLWESILAICESSKGEQKEVNAVDMQLVLRRTEFFLQFDTDYGSMTMQIFEKSPSNYVVKTTSQITGESPSLDFDKMLTEKLNSTWSIPATLTFAITDLKCRINSVLNCVISFDSSSSSDKQHQNYWSISNNNTQLMQSAAQKSAAKCTKKKVTVLEVGPAIEPTQLVYTRENDEEFQGSLLSSFGEVDDYYVKTSTIGRTRPQPRPKREPNQLTSMDMMSAELDKSRHTMEGSMRDAQTSSFLDAARVRMKQSIGAAHAVGLASHQPPASPVAAAAAAPGGPMRHNSYPSGFEPPPSVAPYDFPADPSKKQRKQRAKKQPGEEPPAGRGKGGKKGRGAGAVGAAAAGGRKSAGGAGENPFGMDPMRPPMLQRSSSEQHNPNPHQMSQYQMQQYQQNQQFRMHQMQQQQQQQFQMQSPKNPLVPAYTDEDSDEECDPPPPPKPQVSTSSRMSSVPSHPPPPPQQLGNPMVGYPGMPLQSPNHLPLTPSPLSAPPKPFSPEQQHHFGMKMRETSYWKELERLETKPDVEKLKQQLSSSSSSSQAEASDPPSTSTEAQDPPKPSSSSAPPPPKKKLGLEAAISKIRGQQEQALQKQLQQQESVESELATPHPGSSGAPPLAPHQVNRARNLNDIFDDEADDSSPTADIKPSLQALQKPTDTSSQSTSSEPPPKKEPADEQPEREKEKLILKIPKMLKPVVDDRREDRKERDRDRDRDRDRDEDREKVRDKEDKAQREKDKKEKERERRRQRDRDRTEQKKSDREKEPSKKRKLEKKDEKEKDRREPERKKGKSDGKEYSKASTTSLIPTLSLKNFRIPKKDTVEEEKKDVKEEAPGPSSSTESKKEPPSAAPITRKESTTAPVAPAVQQQQQRKESFTALPSLPEQQQHHREPLLKKKPPLQPPPPPQMTGPPIGIYPGPPAPGNLPGSSRPSGNRKQPLPPPPPMIRGPPPDQMYRDRSGGGGGSMRGGFPPASHYHGGTSGVNKQVASYAQGLPPGMGPPVVKPHGNNYQASQWVRPPTHRDSSHSYHGMPSLGPPQLQREPPAPPPPQMIPLPKDPPVLREHPREHRAHRGGADDDGPDSPEEGTLRIDDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
654	Phosphorylation	ASHQPPASPVAAAAA HCCCCCCCHHHHHHH	26.19	28854356
735	Phosphorylation	AAAGGRKSAGGAGEN HHCCCCCCCCCCCCC	30.68	28854356
800	Phosphorylation	QQQFQMQSPKNPLVP HHHHHHCCCCCCCCC	32.28	21082442
983	Phosphorylation	KQLQQQESVESELAT HHHHHHHHHHHHHCC	27.18	21082442
1023	Phosphorylation	FDDEADDSSPTADIK CCCCCCCCCCCCCCH	38.47	30078680
1024	Phosphorylation	DDEADDSSPTADIKP CCCCCCCCCCCCCHH	33.01	30078680
1026	Phosphorylation	EADDSSPTADIKPSL CCCCCCCCCCCHHHH	38.62	30078680
1239	Phosphorylation	APITRKESTTAPVAP CCCCCCCCCCCCCCH	33.81	19060867
1240	Phosphorylation	PITRKESTTAPVAPA CCCCCCCCCCCCCHH	28.24	30078680
1241	Phosphorylation	ITRKESTTAPVAPAV CCCCCCCCCCCCHHH	37.94	30078680
1257	Phosphorylation	QQQQRKESFTALPSL HHHHHHHCCCCCCCC	30.82	28854356
1259	Phosphorylation	QQRKESFTALPSLPE HHHHHCCCCCCCCHH	36.24	19530675
1263	Phosphorylation	ESFTALPSLPEQQQH HCCCCCCCCHHHHHH	58.36	19530675
1464	Phosphorylation	ADDDGPDSPEEGTLR CCCCCCCCCCCCCCC	37.03	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED1_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of MED1_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.