dbPTM

SHOC2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SHOC2_CAEEL
UniProt AC	Q22875
Protein Name	Leucine-rich repeat protein soc-2
Gene Name	soc-2
Organism	Caenorhabditis elegans.
Sequence Length	559
Subcellular Localization
Protein Description	Acts as a Ras effector and participates in MAPK pathway activation. [PubMed: 9674433]
Protein Sequence	METSKEFEFRPAKETSRSKSPGGIVGRLSNFARNKARHSLSEKGSNSVGGSGGAGFDKPRKDLLKEFHKCKEAQDQRLDLSSIEITSIPSPIKELTQLTELFLYKNKLTCLPTEIGQLVNLKKLGLSENALTSLPDSLASLESLETLDLRHNKLTEVPSVIYKIGSLETLWLRYNRIVAVDEQIGNLSKLKMLDVRENKIRELPSAIGKLTSLVVCLVSYNHLTRVPEEIGDCHSLTQLDLQHNDLSELPYSIGKLVNLVRIGIRYNKIRCIPSELESCQQLEEFIVESNHLQLLPPNLLTMLPKIHTVNLSRNELTAFPAGGPQQFVSTVTINMEHNQISKIPIGIFSKATRLTKLNLKENELVSLPLDMGSWTSITELNLSTNQLKVLPEDIEKLVNLEILVLSNNQLKKLPNQIGNLNKLRELDLEENELETVPTEIGFLQHLTKLWVQSNKILTLPRSIGNLCSLQDLRLGENNLTAIPEEIGHLDSLKSLYLNDNSSLHNLPFELALCQSLEIMSIENSPLSQIPPEITAGGPSLVIQYLKMQGPYRGVVMNSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	PAKETSRSKSPGGIV CCCCCCCCCCCCCHH	36.93	19530675
20	Phosphorylation	KETSRSKSPGGIVGR CCCCCCCCCCCHHHH	29.98	28854356
39	Phosphorylation	ARNKARHSLSEKGSN HHHHHHHHHCCCCCC	28.21	28854356
41	Phosphorylation	NKARHSLSEKGSNSV HHHHHHHCCCCCCCC	40.03	19530675
90	Phosphorylation	IEITSIPSPIKELTQ EEECCCCCCHHHHHH	37.27	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SHOC2_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SHOC2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SHOC2_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
LET60_CAEEL	let-60	physical	14704431

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SHOC2_CAEEL

Related Literatures of Post-Translational Modification