dbPTM

LIN25_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LIN25_CAEEL
UniProt AC	Q10573
Protein Name	Protein lin-25
Gene Name	lin-25
Organism	Caenorhabditis elegans.
Sequence Length	1139
Subcellular Localization	Nucleus . Cytoplasm .
Protein Description	Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade to regulate specification and differentiation of many cell types. [PubMed: 11063686 Positively regulates the fate of vulval precursor cells]
Protein Sequence	MNSIKIDSSTKIVIEYIDKLRNCSNEKRQKVSSVIRPVDFPGISTQQLCDILIRFAYNGTYIDDVFRDHLLKLVVDKSITWNQVIHSVINTKTDRIYSKCLQCELIREMVNYVQIKSFSDKLHADELISIMKPTVFFLAQLIQDVLSDEDELEMIQIEYGDVRKAYYKPLEALSAFIHDDLCSSLLAFSEASEITHQLELCRDSFSKLRSPDKSATTLVEMLIERHIEKCKPVKFQYIPEGIALFDLKNPSIRILIPIFACFKNHESSKLMAETIQTFAEIMRFYGPDVIFDILHGAILLKCEESMDLLHFPKQHRADFRWQSTTFFYKKLPQIIEYLIRSEKLTVAEVQFGLEKALTDLSMMFDAADVAWQNASFLTLLNELEPVLGKTITDPLRLRRREHMKTNDQLLPFADTDNQLIENTDIDKLLNAVKEVMNLQFGQTEEFSKLFVDKVKTGQTDNFDAITSILITEGRLMEVGKAFVLKNVEAQRSSAVGVNERIQIFDDTFILLSRILIKNPSVSINMFVNGGPGKSDAEQTMFYKWSMRYVKRVAKHRDPEPKDETEYIALRKEVEMLMRLANAEVGIEDDLENDVEEEMPEVQEPNIETQNVDEISIPDPLHLLIENDPTVTAESKETEEVKFNPEGVEQMDTNEKPAEISDSLIEPTLLEEPKDILENIIVPIIKVEAPKPDSPIKKKKDPDVTWHEVHCPLPRISRRTARAYLAQMKEGIPFWKTDDPNLNIGSILAAIPRLGQLLVDEHEEKRNRIDRKSAEENMTNILHAIESMPSLFLCLLEWLDCEPESGARTSLAFTINLSLERYLAVSTHGINYMKWIFIKSTVQQMIDELVDKSPAFPEVTCTAFSTARRFCPFVGRNENPDQLKLKHAWYYMRQQAWASPHALRLLEHANTAREYDVWSHIYISKTIKSGCGDIMTSSVDMIFSFLMLDDLNSIIRIHESLMAFWLSEDAGQCQADGRFDPLSIRVVIRLMTQVLLIAEWTLDRLLNEDPAFVERLNLKEVKAPEPEDPDKREKWIFLLRSMLERTINRFFKIVRKGLLSNVVNTIIQLLKSIAGSADCKAKRLLVKRIPPDLIFQLAYIEPSSVDYSLMNIYCDPDNKEHTQTKIMFLCALRRSQSFSF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
693	Phosphorylation	VEAPKPDSPIKKKKD EECCCCCCCCCCCCC	36.73	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LIN25_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LIN25_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LIN25_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HMG12_CAEEL	hmg-1.2	genetic	16845399
CDC42_CAEEL	cdc-42	genetic	16845399
KRAF1_CAEEL	lin-45	genetic	16845399
TIP60_CAEEL	mys-1	genetic	16845399
CNR14_CAEEL	sex-1	genetic	16845399

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LIN25_CAEEL

Related Literatures of Post-Translational Modification