MEX5_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEX5_CAEEL
• UniProt AC: Q9XUB2
• Protein Name: Zinc finger protein mex-5
• Gene Name: mex-5 {ECO:0000312|WormBase:W02A2.7}
• Organism: Caenorhabditis elegans.
• Sequence Length: 468
• Subcellular Localization: Cytoplasm .
• Protein Description: Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. [PubMed: 10882103]
• Protein Sequence: MKAASNSVSSAGGSVSPTTTQPPLPPGQSSHPQIYDQQMQYYFAAAMPNQPMATYAAQNGSSQQYAPAAPYYQDANGQYVQVPANGSMAPQQHMMVSGQPYLYMAQPQQGAQQVMQSGQPQLIYYQQSMAPQAAPMYFHPMQAAPMLPEQMGVMPHTQPAIPPQQQPRQVGVEISSTRTAPLTSSTPLPTSLEYETVQRDNRNRNIQFRYHRVMEHDELPIDEISKITLDNHNDDTMSAEKENHFHEHRGEKFGRRGFPIPETDSQQPPNYKTRLCMMHASGIKPCDMGARCKFAHGLKELRATDAPARYPNNKYKTKLCKNFARGGTGFCPYGLRCEFVHPTDKEFQNIPPYQRMSHDDQDYDQDVIPEDYVVARHQPRFMRTGGRATTPTKVMLKHRNVAGSMMCLSNAGRDLQAGGDYNQPESNEDDLPPHLRRNRRENPPMNKRRTSLSTKWTSEENLGLRGHY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
186	Phosphorylation	TAPLTSSTPLPTSLE CCCCCCCCCCCCCEE	28.72	18199581
450	Phosphorylation	PPMNKRRTSLSTKWT CCCCCCCCCCCCCCC	37.74	19530675
451	Phosphorylation	PMNKRRTSLSTKWTS CCCCCCCCCCCCCCC	20.64	19530675
453	Phosphorylation	NKRRTSLSTKWTSEE CCCCCCCCCCCCCHH	27.92	19530675
454	Phosphorylation	KRRTSLSTKWTSEEN CCCCCCCCCCCCHHH	35.57	19530675
457	Phosphorylation	TSLSTKWTSEENLGL CCCCCCCCCHHHCCC	28.02	30078680
458	Phosphorylation	SLSTKWTSEENLGLR CCCCCCCCHHHCCCC	41.62	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
186	T	Phosphorylation	Kinase	MBK-2	Q9XTF3	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEX5_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEX5_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of MEX5_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- andPAR-1-dependent phosphorylation.";
Tenlen J.R., Molk J.N., London N., Page B.D., Priess J.R.;
Development 135:3665-3675(2008).
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION ATSER-458, AND MUTAGENESIS OF SER-458.
PubMed: 18842813