PCDG5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDG5_HUMAN
• UniProt AC: Q9Y5G8
• Protein Name: Protocadherin gamma-A5
• Gene Name: PCDHGA5
• Organism: Homo sapiens (Human).
• Sequence Length: 931
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MASPPRGWGCGELLLPFMLLGTLCEPGSGQIRYSMPEELDKGSFVGNIAKDLGLEPQELAERGVRIVSRGRTQLFALNPRSGSLVTAGRIDREELCAQSPLCVVNFNILVENKMKIYGVEVEIIDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDADVGVNSLRSYQLSSNLHFSLDVVSGTDGQKYPELVLEQPLDREKETVHDLLLTALDGGDPVLSGTTHIRVTVLDANDNAPLFTPSEYSVSVPENIPVGTRLLMLTATDPDEGINGKLTYSFRNEEEKISETFQLDSNLGEISTLQSLDYEESRFYLMEVVAQDGGALVASAKVVVTVQDVNDNAPEVILTSLTSSISEDCLPGTVIALFSVHDGDSGENGEIACSIPRNLPFKLEKSVDNYYHLLTTRDLDREETSDYNITLTVMDHGTPPLSTESHIPLKVADVNDNPPNFPQASYSTSVTENNPRGVSIFSVTAHDPDSGDNARVTYSLAEDTFQGAPLSSYVSINSDTGVLYALRSFDYEQLRDLQLWVTASDSGNPPLSSNVSLSLFVLDQNDNTPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGLHTGEVRTARALLDRDALKQSLVVAVEDHGQPPLSATFTVTVAVADRIPDILADLGSIKTPIDPEDLDLTLYLVVAVAAVSCVFLAFVIVLLVLRLRRWHKSRLLQAEGSRLAGVPASHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLLSEESCEKSEPLLMSDKVDANKEERRVQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	LFALNPRSGSLVTAG EEEECCCCCCEEEEC	33.71	27251275
191	Phosphorylation	SGTDGQKYPELVLEQ ECCCCCCCCHHHCCC	8.28	-
397	Phosphorylation	LPFKLEKSVDNYYHL CCCCEEECCCCEEEE	25.90	25690035
402	Phosphorylation	EKSVDNYYHLLTTRD EECCCCEEEEEEECC	7.70	25690035
419	N-linked_Glycosylation	REETSDYNITLTVMD CCCCCCCEEEEEEEC	26.26	UniProtKB CARBOHYD
545	N-linked_Glycosylation	GNPPLSSNVSLSLFV CCCCCCCCEEEEEEE	24.83	UniProtKB CARBOHYD
628	Phosphorylation	LHTGEVRTARALLDR ECCCCHHHHHHHCCH	26.18	20068231
753	Phosphorylation	VRAFLQTYSHEVSLT HHHHHHHHCCEEEEC	8.62	25884760
758	Phosphorylation	QTYSHEVSLTADSRK HHHCCEEEECCCCCC	19.61	24961811
818	Phosphorylation	PNTDWRFSQAQRPGT CCCCCCCCCCCCCCC	18.94	25003641
878	Phosphorylation	TMGLSARYGPQFTLQ CCCCCCCCCCCEEEE	32.64	25884760
883	Phosphorylation	ARYGPQFTLQHVPDY CCCCCCEEEEECCCC	21.91	24961811
890	Phosphorylation	TLQHVPDYRQNVYIP EEEECCCCCCCEEEC	14.18	24927040
895	Phosphorylation	PDYRQNVYIPGSNAT CCCCCCEEECCCCCE	14.67	25884760
899	Phosphorylation	QNVYIPGSNATLTNA CCEEECCCCCEECCC	20.24	24719451
902	Phosphorylation	YIPGSNATLTNAAGK EECCCCCEECCCCCC	38.06	27050516
909	Ubiquitination	TLTNAAGKRDGKAPA EECCCCCCCCCCCCC	42.46	32142685
913	Ubiquitination	AAGKRDGKAPAGGNG CCCCCCCCCCCCCCC	56.33	32142685
922	Ubiquitination	PAGGNGNKKKSGKKE CCCCCCCCCCCCCCC	64.08	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDG5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDG5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDG5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCDG9_HUMAN	PCDHGA9	physical	28514442
DCMC_HUMAN	MLYCD	physical	28514442
PCDG7_HUMAN	PCDHGA7	physical	28514442
GINM1_HUMAN	GINM1	physical	28514442
DAG1_HUMAN	DAG1	physical	28514442
PCDG8_HUMAN	PCDHGA8	physical	28514442
AREL1_HUMAN	AREL1	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442
AVR2B_HUMAN	ACVR2B	physical	28514442
MELK_HUMAN	MELK	physical	28514442
SEM6A_HUMAN	SEMA6A	physical	28514442
TM199_HUMAN	TMEM199	physical	28514442
KLH20_HUMAN	KLHL20	physical	28514442
CBX6_HUMAN	CBX6	physical	28514442
MBLC2_HUMAN	MBLAC2	physical	28514442
NB5R1_HUMAN	CYB5R1	physical	28514442
GDF11_HUMAN	GDF11	physical	28514442
RDH13_HUMAN	RDH13	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
SNX14_HUMAN	SNX14	physical	28514442
EPHB4_HUMAN	EPHB4	physical	28514442
MAP7_HUMAN	MAP7	physical	28514442
TM39A_HUMAN	TMEM39A	physical	28514442
DHRS7_HUMAN	DHRS7	physical	28514442
ADCY3_HUMAN	ADCY3	physical	28514442
ITA7_HUMAN	ITGA7	physical	28514442
CNTP3_HUMAN	CNTNAP3	physical	28514442
LTBP1_HUMAN	LTBP1	physical	28514442
DGLB_HUMAN	DAGLB	physical	28514442
Z518A_HUMAN	ZNF518A	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
ERG1_HUMAN	SQLE	physical	28514442
FND3A_HUMAN	FNDC3A	physical	28514442
F189B_HUMAN	FAM189B	physical	28514442
ITA6_HUMAN	ITGA6	physical	28514442
HYEP_HUMAN	EPHX1	physical	28514442
NXPE3_HUMAN	NXPE3	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442
BCD1_HUMAN	ZNHIT6	physical	28514442
BT2A2_HUMAN	BTN2A2	physical	28514442
LRIF1_HUMAN	LRIF1	physical	28514442
TYW1_HUMAN	TYW1	physical	28514442
NSMA_HUMAN	SMPD2	physical	28514442
OSBP1_HUMAN	OSBP	physical	28514442
CDC6_HUMAN	CDC6	physical	28514442
ABCB9_HUMAN	ABCB9	physical	28514442
MP2K7_HUMAN	MAP2K7	physical	28514442
RETST_HUMAN	RETSAT	physical	28514442
AT2A3_HUMAN	ATP2A3	physical	28514442
MARC1_HUMAN	MARC1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.