PCDG8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDG8_HUMAN
• UniProt AC: Q9Y5G5
• Protein Name: Protocadherin gamma-A8
• Gene Name: PCDHGA8
• Organism: Homo sapiens (Human).
• Sequence Length: 932
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MAAPQSRPRRGELILLCALLGTLWEIGRGQIRYSVPEETDKGSFVGNISKDLGLDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDREELCAQSPRCLININTLVEDKGKLFGVEIEIIDINDNNPKFQVEDLEVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLSPNHHFSLDVQTGDNGAINPELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVLDTNDNAPVFPHPIYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVGALLGRTKLLISVEDVNDNRPEVIITSLFSPVLENSLPGTVIAFLSVHDQDSGKNGQVVCYTRDNLPFKLEKSIGNYYRLVTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADINDNPPTFPHASYSAYILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDTLQGAPLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLTELGSLKPSVDPNDSSLTLYLVVAVAAISCVFLAFVAVLLGLRLRRWHKSRLLQDSGGRLVGVPASHFVGVEEVQAFLQTYSQEVSLTADSRKSHLIFPQPNYADMLISQEGCEKNDSLLTSVDFHEYKNEADHGQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	N-linked_Glycosylation	DKGSFVGNISKDLGL CCCCEEEEHHHCCCC	30.02	UniProtKB CARBOHYD
213	Phosphorylation	AAHHLVLTASDGGKP HHHEEEEEECCCCCC	19.35	-
215	Phosphorylation	HHLVLTASDGGKPPR HEEEEEECCCCCCCC	31.39	-
223	Phosphorylation	DGGKPPRSSTVRIHV CCCCCCCCCEEEEEE	35.81	17081983
224	Phosphorylation	GGKPPRSSTVRIHVT CCCCCCCCEEEEEEE	32.00	17081983
225	Phosphorylation	GKPPRSSTVRIHVTV CCCCCCCEEEEEEEE	18.30	17081983
259	Phosphorylation	LENMPPGTRLLTVTA HHCCCCCCEEEEEEE	24.74	23532336
414	N-linked_Glycosylation	RKYLDRENVSIYNIT HHHHCCCCEEEEEEE	33.46	UniProtKB CARBOHYD
419	N-linked_Glycosylation	RENVSIYNITVMASD CCCEEEEEEEEEHHH	23.06	UniProtKB CARBOHYD
545	N-linked_Glycosylation	GDPPLSSNMSLSLFV CCCCCCCCCEEEEEE	22.23	UniProtKB CARBOHYD
628	Phosphorylation	LHTGEVRTARALLDR CCCCCHHHHHHHCCH	26.18	20068231
685	N-linked_Glycosylation	LKPSVDPNDSSLTLY CCCCCCCCCCHHHHH	58.28	UniProtKB CARBOHYD
819	Phosphorylation	PNTDWRFSQAQRPGT CCCCCCCCCCCCCCC	18.94	25003641
879	Phosphorylation	TMGLSARYGPQFTLQ CCCCCCCCCCCEEEE	32.64	25884760
884	Phosphorylation	ARYGPQFTLQHVPDY CCCCCCEEEEECCCC	21.91	24961811
891	Phosphorylation	TLQHVPDYRQNVYIP EEEECCCCCCCEEEC	14.18	24927040
896	Phosphorylation	PDYRQNVYIPGSNAT CCCCCCEEECCCCCE	14.67	25884760
900	Phosphorylation	QNVYIPGSNATLTNA CCEEECCCCCEECCC	20.24	24719451
903	Phosphorylation	YIPGSNATLTNAAGK EECCCCCEECCCCCC	38.06	27050516
910	Ubiquitination	TLTNAAGKRDGKAPA EECCCCCCCCCCCCC	42.46	32142685
914	Ubiquitination	AAGKRDGKAPAGGNG CCCCCCCCCCCCCCC	56.33	32142685
923	Ubiquitination	PAGGNGNKKKSGKKE CCCCCCCCCCCCCCC	64.08	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDG8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDG8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDG8_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCDG8_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.