CDC26_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDC26_MOUSE
• UniProt AC: Q99JP4
• Protein Name: Anaphase-promoting complex subunit CDC26
• Gene Name: Cdc26
• Organism: Mus musculus (Mouse).
• Sequence Length: 85
• Subcellular Localization: Nucleus.
• Protein Description: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity)..
• Protein Sequence: MLRRKPTRLELKLDDIEEFESIRKDLEARKKQKEDVEGVGTSDGEGAAGLSSDPKSREQMINDRIGYKPQLKSNNRTSQFGNFEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLRRKPTRLELKLD -CCCCCCCCEEEEHH	51.42	-
41	Phosphorylation	EDVEGVGTSDGEGAA HHCCCCCCCCCCCCC	22.65	25521595
42	Phosphorylation	DVEGVGTSDGEGAAG HCCCCCCCCCCCCCC	37.38	25521595
51	Phosphorylation	GEGAAGLSSDPKSRE CCCCCCCCCCHHHHH	31.60	25619855
52	Phosphorylation	EGAAGLSSDPKSREQ CCCCCCCCCHHHHHH	64.08	25619855
67	Phosphorylation	MINDRIGYKPQLKSN HHHCCCCCCCCCCCC	19.68	29514104
73	Phosphorylation	GYKPQLKSNNRTSQF CCCCCCCCCCCCCCC	48.18	26643407
77	Phosphorylation	QLKSNNRTSQFGNFE CCCCCCCCCCCCCCC	29.07	26643407
78	Phosphorylation	LKSNNRTSQFGNFEF CCCCCCCCCCCCCCC	21.92	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDC26_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDC26_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDC26_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BUB1B_HUMAN	BUB1B	physical	26496610
CDC20_HUMAN	CDC20	physical	26496610
CDC27_HUMAN	CDC27	physical	26496610
CDN2A_HUMAN	CDKN2A	physical	26496610
ARF_HUMAN	CDKN2A	physical	26496610
CO4A1_HUMAN	COL4A1	physical	26496610
ADX_HUMAN	FDX1	physical	26496610
HD_HUMAN	HTT	physical	26496610
I5P2_HUMAN	INPP5B	physical	26496610
MECP2_HUMAN	MECP2	physical	26496610
MSH3_HUMAN	MSH3	physical	26496610
NEK2_HUMAN	NEK2	physical	26496610
PRDX1_HUMAN	PRDX1	physical	26496610
PEX10_HUMAN	PEX10	physical	26496610
PIPNA_HUMAN	PITPNA	physical	26496610
PLOD1_HUMAN	PLOD1	physical	26496610
RIR2_HUMAN	RRM2	physical	26496610
LAP2A_HUMAN	TMPO	physical	26496610
LAP2B_HUMAN	TMPO	physical	26496610
HIRA_HUMAN	HIRA	physical	26496610
ZNF12_HUMAN	ZNF12	physical	26496610
CDC23_HUMAN	CDC23	physical	26496610
CDC16_HUMAN	CDC16	physical	26496610
BUB3_HUMAN	BUB3	physical	26496610
BCL7B_HUMAN	BCL7B	physical	26496610
SCAM3_HUMAN	SCAMP3	physical	26496610
VINEX_HUMAN	SORBS3	physical	26496610
MARH6_HUMAN	MARCH6	physical	26496610
CEPT1_HUMAN	CEPT1	physical	26496610
APC10_HUMAN	ANAPC10	physical	26496610
HOIL1_HUMAN	RBCK1	physical	26496610
PRDX3_HUMAN	PRDX3	physical	26496610
RPC1_HUMAN	POLR3A	physical	26496610
HPS5_HUMAN	HPS5	physical	26496610
SI1L3_HUMAN	SIPA1L3	physical	26496610
CAMP2_HUMAN	CAMSAP2	physical	26496610
UBR2_HUMAN	UBR2	physical	26496610
NNTM_HUMAN	NNT	physical	26496610
APC13_HUMAN	ANAPC13	physical	26496610
APC15_HUMAN	ANAPC15	physical	26496610
FBX5_HUMAN	FBXO5	physical	26496610
ANR11_HUMAN	ANKRD11	physical	26496610
ANC2_HUMAN	ANAPC2	physical	26496610
APC4_HUMAN	ANAPC4	physical	26496610
RM37_HUMAN	MRPL37	physical	26496610
FZR1_HUMAN	FZR1	physical	26496610
APC5_HUMAN	ANAPC5	physical	26496610
APC7_HUMAN	ANAPC7	physical	26496610
SIR6_HUMAN	SIRT6	physical	26496610
MREG_HUMAN	MREG	physical	26496610
PARD3_HUMAN	PARD3	physical	26496610
TOM22_HUMAN	TOMM22	physical	26496610
CFA97_HUMAN	CFAP97	physical	26496610
E41L5_HUMAN	EPB41L5	physical	26496610
APC1_HUMAN	ANAPC1	physical	26496610
GNPTA_HUMAN	GNPTAB	physical	26496610
KI18A_HUMAN	KIF18A	physical	26496610
GNPTG_HUMAN	GNPTG	physical	26496610
RRFM_HUMAN	MRRF	physical	26496610
APC16_HUMAN	ANAPC16	physical	26496610
RM55_HUMAN	MRPL55	physical	26496610
TTC9C_HUMAN	TTC9C	physical	26496610
HNRC1_HUMAN	HNRNPCL1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.