ZSC20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZSC20_HUMAN
• UniProt AC: P17040
• Protein Name: Zinc finger and SCAN domain-containing protein 20
• Gene Name: ZSCAN20
• Organism: Homo sapiens (Human).
• Sequence Length: 1043
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAMALELQAQASPQPEPEELLIVKLEEDSWGSESKLWEKDRGSVSGPEASRQRFRQFQYRDAAGPHEAFSQLWALCCRWLRPEIRLKEQILELLVLEQFLTILPREVQTWVQARHPESGEEAVALVEDWHRETRTAGQSGLELHTEETRPLKTGEEAQSFQLQPVDPWPEGQSQKKGVKNTCPDLPNHLNAEVAPQPLKESAVLTPRVPTLPKMGSVGDWEVTAESQEALGPGKHAEKELCKDPPGDDCGNSVCLGVPVSKPSNTSEKEQGPEFWGLSLINSGKRSTADYSLDNEPAQALTWRDSRAWEEQYQWDVEDMKVSGVHWGYEETKTFLAILSESPFSEKLRTCHQNRQVYRAIAEQLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRATDGPGEAVALPRLGYSDAEMDEQEEGGWDPEEMAEDCNGAGLVNVESTQGPRIAGAPALFQSRIAGVHWGYEETKAFLAILSESPFSEKLRTCHQNSQVYRAIAERLCALGFLRTLEQCRYRFKNLLRSYRKAKSSHPPGTCPFYEELDSLMRARAAVRAMGTVREAAGLPRCGQSSAETDAQEAWGEVANEDAVKPSTLCPKAPDMGFEMRHEDEDQISEQDIFEGLPGALSKCPTEAVCQPLDWGEDSENENEDEGQWGNPSQEQWQESSSEEDLEKLIDHQGLYLAEKPYKCDTCMKSFSRSSHFIAHQRIHTGEKPYKCLECGKNFSDRSNLNTHQRIHTGEKPYKCLECGKSFSDHSNLITHQRIHTGEKPYKCGECWKSFNQSSNLLKHQRIHLGGNPDQCSEPGGNFAQSPSFSAHWRNSTEETAPEQPQSISKDLNSPGPHSTNSGEKLYECSECGRSFSKSSALISHQRIHTGEKPYECAECGKSFSKSSTLANHQRTHTGEKPYKCVDCGKCFSERSKLITHQRVHTGEKPYKCLECGKFFRDRSNLITHQRIHTGEKPYKCRECGKCFNQSSSLIIHQRIHTGEKPYKCTECGKDFNNSSHFSAHRRTHAGGKAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	LELQAQASPQPEPEE HHHHHHCCCCCCCCC	16.40	29507054
35	Ubiquitination	DSWGSESKLWEKDRG CCCCCCCCCCCCCCC	54.27	-
50	Phosphorylation	SVSGPEASRQRFRQF CCCCHHHHHHHHHHH	27.55	24732914
133	Phosphorylation	VEDWHRETRTAGQSG HHHHHHHHHCCCCCC	33.02	29507054
135	Phosphorylation	DWHRETRTAGQSGLE HHHHHHHCCCCCCCE	42.43	29507054
145	Phosphorylation	QSGLELHTEETRPLK CCCCEEECCCCCCCC	48.41	29507054
205	Phosphorylation	LKESAVLTPRVPTLP CCCCCCCCCCCCCCC	11.49	-
282	Phosphorylation	WGLSLINSGKRSTAD CEEEEECCCCCCCCC	38.40	-
339	Phosphorylation	KTFLAILSESPFSEK HHHHHHHCCCCCCHH	29.89	22199227
341	Phosphorylation	FLAILSESPFSEKLR HHHHHCCCCCCHHHH	28.06	21815630
392	Phosphorylation	RNYRKAKSSHPPGTC HHHHHHHHCCCCCCC	38.44	-
402	Phosphorylation	PPGTCPFYEELEALV CCCCCCHHHHHHHHH	8.14	-
499	Phosphorylation	KAFLAILSESPFSEK HHHHHHHHCCCCCHH	29.89	22199227
501	Phosphorylation	FLAILSESPFSEKLR HHHHHHCCCCCHHHH	28.06	28348404
504	Phosphorylation	ILSESPFSEKLRTCH HHHCCCCCHHHHHHH	36.89	22199227
567	Phosphorylation	PFYEELDSLMRARAA CHHHHHHHHHHHHHH	36.37	-
637	Phosphorylation	HEDEDQISEQDIFEG CCCCCCCCHHHHHCC	24.46	30108239
710	Phosphorylation	LYLAEKPYKCDTCMK CEECCCCCCCCCHHH	35.00	-
720	Phosphorylation	DTCMKSFSRSSHFIA CCHHHHCCCCCCHHE	38.04	17081983
733	Phosphorylation	IAHQRIHTGEKPYKC HEECCCCCCCCCEEE	44.67	29496963
738	Phosphorylation	IHTGEKPYKCLECGK CCCCCCCEEEECCCC	25.96	15592455
739	Sumoylation	HTGEKPYKCLECGKN CCCCCCEEEECCCCC	40.65	-
739	Sumoylation	HTGEKPYKCLECGKN CCCCCCEEEECCCCC	40.65	-
755	Phosphorylation	SDRSNLNTHQRIHTG CCCCCCCCCCCCCCC	23.66	-
761	Phosphorylation	NTHQRIHTGEKPYKC CCCCCCCCCCCCEEE	44.67	29496963
766	Phosphorylation	IHTGEKPYKCLECGK CCCCCCCEEEECCCC	25.96	15592455
767	Sumoylation	HTGEKPYKCLECGKS CCCCCCEEEECCCCC	40.65	-
767	Sumoylation	HTGEKPYKCLECGKS CCCCCCEEEECCCCC	40.65	-
789	Phosphorylation	ITHQRIHTGEKPYKC CCCCEEECCCCCCCC	44.67	29496963
834	Phosphorylation	PGGNFAQSPSFSAHW CCCCCCCCCCCCCCC	21.05	-
857	Phosphorylation	PEQPQSISKDLNSPG CCCCCCCCCCCCCCC	25.93	-
862	Phosphorylation	SISKDLNSPGPHSTN CCCCCCCCCCCCCCC	38.23	23663014
867	Phosphorylation	LNSPGPHSTNSGEKL CCCCCCCCCCCCCCE	32.20	29255136
868	Phosphorylation	NSPGPHSTNSGEKLY CCCCCCCCCCCCCEE	30.30	29255136
883	Phosphorylation	ECSECGRSFSKSSAL ECCCCCCCCCCCHHH	21.11	24719451
898	Phosphorylation	ISHQRIHTGEKPYEC HCCCEECCCCCCCCH	44.67	28111955
911	Phosphorylation	ECAECGKSFSKSSTL CHHHCCCCCCCCHHH	21.75	24719451
924	Phosphorylation	TLANHQRTHTGEKPY HHCCCCCCCCCCCCE	19.74	28348404
926	Phosphorylation	ANHQRTHTGEKPYKC CCCCCCCCCCCCEEE	46.56	26270265
929	Ubiquitination	QRTHTGEKPYKCVDC CCCCCCCCCEEEECC	55.80	-
945	Sumoylation	KCFSERSKLITHQRV CCCCCCCCCCCCCCC	50.56	-
945	Sumoylation	KCFSERSKLITHQRV CCCCCCCCCCCCCCC	50.56	-
954	Phosphorylation	ITHQRVHTGEKPYKC CCCCCCCCCCCCEEE	44.15	29496963
957	Ubiquitination	QRVHTGEKPYKCLEC CCCCCCCCCEEEECC	55.80	-
957	Sumoylation	QRVHTGEKPYKCLEC CCCCCCCCCEEEECC	55.80	-
957	Sumoylation	QRVHTGEKPYKCLEC CCCCCCCCCEEEECC	55.80	-
960	Sumoylation	HTGEKPYKCLECGKF CCCCCCEEEECCCCC	40.65	-
960	Sumoylation	HTGEKPYKCLECGKF CCCCCCEEEECCCCC	40.65	-
966	Ubiquitination	YKCLECGKFFRDRSN EEEECCCCCCCCCCC	53.65	-
982	Phosphorylation	ITHQRIHTGEKPYKC CCCCCCCCCCCCEEC	44.67	29496963
999	Phosphorylation	CGKCFNQSSSLIIHQ CHHHCCCCCCEEEEE	24.01	23186163
1000	Phosphorylation	GKCFNQSSSLIIHQR HHHCCCCCCEEEEEE	21.28	23186163
1001	Phosphorylation	KCFNQSSSLIIHQRI HHCCCCCCEEEEEEE	28.91	25106551
1010	Phosphorylation	IIHQRIHTGEKPYKC EEEEEEECCCCCEEC	44.67	29496963

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZSC20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZSC20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZSC20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCND1_HUMAN	SCAND1	physical	16189514
EPIPL_HUMAN	EPPK1	physical	26186194
HMOX1_HUMAN	HMOX1	physical	26186194
SCND3_HUMAN	ZBED9	physical	26186194
ZN232_HUMAN	ZNF232	physical	26186194
ZKSC5_HUMAN	ZKSCAN5	physical	26186194
ZSC21_HUMAN	ZSCAN21	physical	26186194
ZKSC3_HUMAN	ZKSCAN3	physical	26186194
ZKSC4_HUMAN	ZKSCAN4	physical	26186194
ZSC25_HUMAN	ZSCAN25	physical	26186194
ZN449_HUMAN	ZNF449	physical	26186194
ZKSC8_HUMAN	ZKSCAN8	physical	26186194
ZKSC1_HUMAN	ZKSCAN1	physical	26186194
ZSC30_HUMAN	ZSCAN30	physical	26186194
ZNF24_HUMAN	ZNF24	physical	26186194
ZSC22_HUMAN	ZSCAN22	physical	26186194
ZSC23_HUMAN	ZSCAN23	physical	26186194
ZN215_HUMAN	ZNF215	physical	26186194
TRI29_HUMAN	TRIM29	physical	26186194
PGBD1_HUMAN	PGBD1	physical	26186194
SBSN_HUMAN	SBSN	physical	26186194
CAPG_HUMAN	CAPG	physical	26186194
EVPL_HUMAN	EVPL	physical	26186194
ANXA1_HUMAN	ANXA1	physical	26186194
ZN197_HUMAN	ZNF197	physical	26186194
POF1B_HUMAN	POF1B	physical	26186194
SPB4_HUMAN	SERPINB4	physical	26186194
SPB3_HUMAN	SERPINB3	physical	26186194
ZN174_HUMAN	ZNF174	physical	26186194
ZSC29_HUMAN	ZSCAN29	physical	26186194
SCND1_HUMAN	SCAND1	physical	26186194
INVO_HUMAN	IVL	physical	26186194
PEPL_HUMAN	PPL	physical	26186194
ADNP_HUMAN	ADNP	physical	26186194
ZSC18_HUMAN	ZSCAN18	physical	26186194
HUTH_HUMAN	HAL	physical	26186194
ZN213_HUMAN	ZNF213	physical	26186194
ZN394_HUMAN	ZNF394	physical	26186194
TYPH_HUMAN	TYMP	physical	26186194
KLK10_HUMAN	KLK10	physical	26186194
CALL5_HUMAN	CALML5	physical	26186194
ZN263_HUMAN	ZNF263	physical	26186194
ZN445_HUMAN	ZNF445	physical	26186194
ZKSC3_HUMAN	ZKSCAN3	physical	28514442
ZSC29_HUMAN	ZSCAN29	physical	28514442
ZN174_HUMAN	ZNF174	physical	28514442
ZSC30_HUMAN	ZSCAN30	physical	28514442
ZSC18_HUMAN	ZSCAN18	physical	28514442
ZKSC4_HUMAN	ZKSCAN4	physical	28514442
ZSC21_HUMAN	ZSCAN21	physical	28514442
ZN213_HUMAN	ZNF213	physical	28514442
ZN394_HUMAN	ZNF394	physical	28514442
ZKSC1_HUMAN	ZKSCAN1	physical	28514442
SCND3_HUMAN	ZBED9	physical	28514442
ZN197_HUMAN	ZNF197	physical	28514442
ZN263_HUMAN	ZNF263	physical	28514442
PGBD1_HUMAN	PGBD1	physical	28514442
SCND1_HUMAN	SCAND1	physical	28514442
TIM50_HUMAN	TIMM50	physical	28514442
ZNF24_HUMAN	ZNF24	physical	28514442
PEPL_HUMAN	PPL	physical	28514442
ZKSC8_HUMAN	ZKSCAN8	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442
ZSC23_HUMAN	ZSCAN23	physical	28514442
ADNP_HUMAN	ADNP	physical	28514442
TREX2_HUMAN	TREX2	physical	28514442
EVPL_HUMAN	EVPL	physical	28514442
ZN449_HUMAN	ZNF449	physical	28514442
ZKSC5_HUMAN	ZKSCAN5	physical	28514442
KLK10_HUMAN	KLK10	physical	28514442
ZSC22_HUMAN	ZSCAN22	physical	28514442
INVO_HUMAN	IVL	physical	28514442
ZSC25_HUMAN	ZSCAN25	physical	28514442
ZN215_HUMAN	ZNF215	physical	28514442
TRI29_HUMAN	TRIM29	physical	28514442
TYPH_HUMAN	TYMP	physical	28514442
H15_HUMAN	HIST1H1B	physical	28514442
CALL5_HUMAN	CALML5	physical	28514442
SPB3_HUMAN	SERPINB3	physical	28514442
ZN445_HUMAN	ZNF445	physical	28514442
SBSN_HUMAN	SBSN	physical	28514442
CAPG_HUMAN	CAPG	physical	28514442
POF1B_HUMAN	POF1B	physical	28514442
CO3_HUMAN	C3	physical	28514442
HUTH_HUMAN	HAL	physical	28514442
ZN202_HUMAN	ZNF202	physical	28514442
IL36G_HUMAN	IL36G	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.