dbPTM

ZN449_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN449_HUMAN
UniProt AC	Q6P9G9
Protein Name	Zinc finger protein 449
Gene Name	ZNF449
Organism	Homo sapiens (Human).
Sequence Length	518
Subcellular Localization	Nucleus .
Protein Description	May be involved in transcriptional regulation..
Protein Sequence	MAVALGCAIQASLNQGSVFQEYDTDCEVFRQRFRQFQYREAAGPHEAFNKLWELCCQWLKPKMRSKEQILELLVLEQFLTILPTEIETWVREHCPENRERVVSLIEDLQRELEIPEQQVDMHDMLLEELAPVGTAHIPPTMHLESPALQVMGPAQEAPVAEAWIPQAGPPELNYGATGECQNFLDPGYPLPKLDMNFSLENREEPWVKELQDSKEMKQLLDSKIGFEIGIENEEDTSKQKKMETMYPFIVTLEGNALQGPILQKDYVQLENQWETPPEDLQTDLAKLVDQQNPTLGETPENSNLEEPLNPKPHKKKSPGEKPHRCPQCGKCFARKSQLTGHQRIHSGEEPHKCPECGKRFLRSSDLYRHQRLHTGERPYECTVCKKRFTRRSHLIGHQRTHSEEETYKCLECGKSFCHGSSLKRHLKTHTGEKPHRCHNCGKSFSRLTALTLHQRTHTEERPFKCNYCGKSFRQRPSLVIHLRIHTGEKPYKCTHCSKSFRQRAGLIMHQVTHFRGLI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
222	O-linked_Glycosylation	EMKQLLDSKIGFEIG HHHHHHHHHHCCCCC	26.58	31492838
298	Phosphorylation	QNPTLGETPENSNLE CCCCCCCCCCCCCCC	33.82	-
315	"N6,N6-dimethyllysine"	LNPKPHKKKSPGEKP CCCCCCCCCCCCCCC	56.29	-
315	Methylation	LNPKPHKKKSPGEKP CCCCCCCCCCCCCCC	56.29	-
316	Ubiquitination	NPKPHKKKSPGEKPH CCCCCCCCCCCCCCC	67.68	-
445	Phosphorylation	HNCGKSFSRLTALTL CCCCCCHHHHHHHHH	33.21	17081983
451	Phosphorylation	FSRLTALTLHQRTHT HHHHHHHHHHCCCCC	21.52	22210691
486	Phosphorylation	VIHLRIHTGEKPYKC EEEEEEECCCCCEEC	44.67	29496963

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZN449_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN449_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN449_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZN449_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN449_HUMAN

Related Literatures of Post-Translational Modification