UBP4_SCHPO - dbPTM
UBP4_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBP4_SCHPO
UniProt AC O60139
Protein Name Probable ubiquitin carboxyl-terminal hydrolase 4
Gene Name ubp4
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 593
Subcellular Localization Cytoplasm. Endosome.
Protein Description Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Acts late in the proteolytic pathway in conjunction with the 26S proteasome. Plays a role in avoiding DNA overreplication (By similarity)..
Protein Sequence MSDDYFDRLFELAFVYINEDETIQSCSFRGQRWLEEAQTLEQKNSLLKAYYYYLKALKLAYEIPCRFEISVKSTHYGEFKQFQKLAIQAVSKAFTIKSKLAVKHYLPVIQISDALSLSKKSSLKVLFLNFYSQESSKGYVFSKHTIAIPISCLQSMDSSKIYDFLKSAPFHPSMVICYSLERYFEDVSLAYKLYSMLRSLKLDPHFMELANPKKVDSSLSYENYQPIGLTNLGNTCYMNCVLQCLFACKDLTIPMLQGRGLLQNINTKNPLGTGGKITSAFFSLLQSVLLNHGQRSISPRNFLEIVQSLNRDFSIDGQCDAQEFLNFFLDKLHEDLNSNASRSPIAPLTEDQLSAREELPLSHFSHIEWNLHLRSNKSIVVNNFVGQLCSRTQCMTCGRTSTTFAPFTSLAIPIDDVSHVVSLQECLLKFSAPELLQGHDGWHCPVCKVQRSAKKVIMISKLPEYLIIQIQRFKISVMGRKKIDTPLGLSLQIPSKMLVPPSFQSGIGYIPSNYNLFAFICHYGQLENGHYISDVLFNNEWCHIDDSIVRTVGGITDLREDFSSSYILFYKRSSLLEEFEDKCPKMTLKRNVK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
188PhosphorylationERYFEDVSLAYKLYS
HHHHCCHHHHHHHHH		21.4328889911
338PhosphorylationKLHEDLNSNASRSPI
HHHHHHHCCCCCCCC		40.8628889911
341PhosphorylationEDLNSNASRSPIAPL
HHHHCCCCCCCCCCC		37.2329996109
343PhosphorylationLNSNASRSPIAPLTE
HHCCCCCCCCCCCCH		20.4028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBP4_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBP4_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBP4_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS24_SCHPOvps24genetic
19547744
SFP47_SCHPOsfp47physical
20838651
SGF29_SCHPOsgf29genetic
18818364
EIF2A_SCHPOSPBC4B4.04genetic
18818364
SUM2_SCHPOsum2genetic
18818364
HPC2_SCHPOhip4genetic
18818364
SET1_SCHPOset1genetic
18818364
SPP1_SCHPOspf1genetic
18818364
VPH2_SCHPOvph2genetic
18818364
CCR4_SCHPOccr4genetic
18818364
MPC2_SCHPOmpc2genetic
22681890
RYH1_SCHPOryh1genetic
22681890
YEC6_SCHPOpcf3genetic
22681890
HRP3_SCHPOhrp3genetic
22681890
RCQ1_SCHPOrqc1genetic
22681890
YIP4_SCHPOSPAC644.13cgenetic
22681890
YDEF_SCHPOSPAC12B10.15cgenetic
22681890
PPIH_SCHPOcyp3genetic
22681890
YDPH_SCHPOSPAC29A4.17cgenetic
22681890
SSR3_SCHPOssr3genetic
22681890
YM08_SCHPOSPAC212.08cgenetic
22681890
YL33_SCHPOsil1genetic
22681890
YEG3_SCHPOpcf2genetic
22681890
YHAH_SCHPOSPBC409.17cgenetic
22681890
VAM7_SCHPOSPCC594.06cgenetic
22681890
PROB_SCHPOSPAC17H9.13cgenetic
22681890
LYS1_SCHPOlys3genetic
22681890
PDX1_SCHPOsnz1genetic
22681890
VPS1_SCHPOvps1genetic
22681890
SKH1_SCHPOpek1genetic
22681890
CSK2C_SCHPOckb2genetic
22681890
MU134_SCHPOSPAC10F6.15genetic
22681890
SWD3_SCHPOswd3genetic
22681890
ARGJ_SCHPOSPBC1271.14genetic
22681890
RAD55_SCHPOrad55genetic
22681890
MU114_SCHPOmug114genetic
22681890
SKB5_SCHPOskb5genetic
22681890
SEL1_SCHPOsle1genetic
22681890
CAO1_SCHPOcao1genetic
22681890
YIT2_SCHPOSPAC105.02cgenetic
22681890
YKX4_SCHPOSPAC328.04genetic
22681890
RSC4_SCHPOrsc4genetic
22681890
NAGS_SCHPOarg6genetic
22681890
HHP2_SCHPOhhp2genetic
22681890
SIB1_SCHPOsib1genetic
22681890
HOSM_SCHPOlys4genetic
22681890
GPA2_SCHPOgpa2genetic
22681890
YEX1_SCHPOSPAC1A6.01cgenetic
22681890
LYS4_SCHPOlys2genetic
22681890
MTHR2_SCHPOmet11genetic
22681890
MSH6_SCHPOmsh6genetic
22681890
TLS1_SCHPOtls1genetic
22681890
MYO3_SCHPOmyp2genetic
22681890
HPM1_SCHPOSPAC1071.05genetic
22681890
DSD1_SCHPOSPAC1039.06genetic
22681890
YF75_SCHPOspa2genetic
22681890
DIOXL_SCHPOSPBC1709.16cgenetic
22681890
MU117_SCHPOmug117genetic
22681890
ZHF1_SCHPOzhf1genetic
22681890
EXG1_SCHPOexg1genetic
22681890
MUG96_SCHPOmug96genetic
22681890
YOO8_SCHPOSPBC887.08genetic
22681890
ARG56_SCHPOarg11genetic
22681890
PIT1_SCHPOpit1genetic
22681890
MU191_SCHPOmug191genetic
22681890
ALM1_SCHPOalm1genetic
22681890
YK15_SCHPOSPAPB1A10.05genetic
22681890
YAO3_SCHPOSPAC11D3.03cgenetic
22681890
OS9_SCHPOSPAC227.11cgenetic
22681890
ARGI2_SCHPOaru1genetic
22681890
LTN1_SCHPOrkr1genetic
22681890
YA98_SCHPOSPAC13G6.08genetic
22681890
YAY6_SCHPOSPAC4H3.06genetic
22681890
TIP1_SCHPOtip1genetic
22681890
YD3B_SCHPOSPAC13G7.11genetic
22681890
UBP2_SCHPOubp2genetic
22681890
EMC1_SCHPOemc1genetic
22681890
YBI8_SCHPOoga1genetic
22681890
ASSY_SCHPOarg12genetic
22681890
MALT_SCHPOmal1genetic
22681890
YF51_SCHPOsac12genetic
22681890
RGA8_SCHPOrga8genetic
22681890
LYS12_SCHPOlys12genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBP4_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND SER-343, ANDMASS SPECTROMETRY.

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