dbPTM

TR10A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TR10A_HUMAN
UniProt AC	O00220
Protein Name	Tumor necrosis factor receptor superfamily member 10A
Gene Name	TNFRSF10A
Organism	Homo sapiens (Human).
Sequence Length	468
Subcellular Localization	Membrane Single-pass type I membrane protein.
Protein Description	Receptor for the cytotoxic ligand TNFSF10/TRAIL. [PubMed: 26457518 The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.]
Protein Sequence	MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Ubiquitination	AAAATPSKVWGSSAG CCCCCCCHHCCCCCC	43.12	21906983
52	Methylation	IEPRGGGRGALPTSM CCCCCCCCCCCCCCC	30.41	24129315
57	O-linked_Glycosylation	GGRGALPTSMGQHGP CCCCCCCCCCCCCCH	31.99	OGP
83	Phosphorylation	PRPAREASPRLRVHK CCCCCCCCCCCCCCC	13.05	22817900
126	O-linked_Glycosylation	GTQQWEHSPLGELCP CCCCCCCCCCCCCCC	15.42	OGP
156	N-linked_Glycosylation	TEGVGYTNASNNLFA CCCCCCCCCCCCEEE	32.65	UniProtKB CARBOHYD
178	Phosphorylation	KSDEEERSPCTTTRN CCCHHHCCCCCCCCC	27.83	25159151
191	Ubiquitination	RNTACQCKPGTFRND CCCCCCCCCCCCCCC	22.17	21963094
217	Ubiquitination	GCPRGMVKVKDCTPW CCCCCCEECCCCCCH	34.37	27667366
219	Ubiquitination	PRGMVKVKDCTPWSD CCCCEECCCCCCHHH	41.17	29967540
261	S-palmitoylation	LVAVLIVCCCIGSGC HHHHHHHHHHHCCCC	0.93	19090789
262	S-palmitoylation	VAVLIVCCCIGSGCG HHHHHHHHHHCCCCC	1.00	19090789
263	S-palmitoylation	AVLIVCCCIGSGCGG HHHHHHHHHCCCCCC	3.14	19090789
273	Ubiquitination	SGCGGDPKCMDRVCF CCCCCCHHHHHHHHH	47.10	-
336	S-nitrosylation	QSPGEAQCLLGPAEA CCCCCEEEEECCCCC	4.34	22178444
336	S-nitrosocysteine	QSPGEAQCLLGPAEA CCCCCEEEEECCCCC	4.34	-
379	Phosphorylation	ANIVPFDSWDQLMRQ CCCCCCCCHHHHHHH	32.69	22210691
390	Phosphorylation	LMRQLDLTKNEIDVV HHHHHCCCCCCCCEE	31.33	22210691
391	Ubiquitination	MRQLDLTKNEIDVVR HHHHCCCCCCCCEEE	60.94	21906983
424	Phosphorylation	NKTGRNASIHTLLDA HHHCCCCHHHHHHHH	20.60	22617229
424	O-linked_Glycosylation	NKTGRNASIHTLLDA HHHCCCCHHHHHHHH	20.60	30987996
427	Phosphorylation	GRNASIHTLLDALER CCCCHHHHHHHHHHH	27.61	20873877
443	Ubiquitination	EERHAREKIQDLLVD HHHHHHHHHHHHHHH	39.86	21906983
453	Ubiquitination	DLLVDSGKFIYLEDG HHHHHCCCEEEEECC	32.32	29967540
456	Phosphorylation	VDSGKFIYLEDGTGS HHCCCEEEEECCCCC	13.74	25884760
461	Phosphorylation	FIYLEDGTGSAVSLE EEEEECCCCCCEECC	40.04	28176443
463	Phosphorylation	YLEDGTGSAVSLE-- EEECCCCCCEECC--	25.90	26503892
466	Phosphorylation	DGTGSAVSLE----- CCCCCCEECC-----	26.88	26503892

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF5	Q9NX47	PMID:23300075

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TR10A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TR10A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL10_HUMAN	BCL10	physical	10400625
CASP8_HUMAN	CASP8	physical	9325248
CASPA_HUMAN	CASP10	physical	9325248
CFLAR_HUMAN	CFLAR	physical	9325248
RT29_HUMAN	DAP3	physical	11376335
TRADD_HUMAN	TRADD	physical	9430227
FADD_HUMAN	FADD	physical	9430227
TNF10_HUMAN	TNFSF10	physical	9082980
CBL_HUMAN	CBL	physical	19932172
CFLAR_HUMAN	CFLAR	physical	19343040
CASP8_HUMAN	CASP8	physical	19343040
FADD_HUMAN	FADD	physical	15280356
CASP8_HUMAN	CASP8	physical	15280356
CASP8_HUMAN	CASP8	physical	15388581
FADD_HUMAN	FADD	physical	15388581
TR10B_HUMAN	TNFRSF10B	physical	15388581
SQSTM_HUMAN	SQSTM1	physical	19427028
CASP8_HUMAN	CASP8	physical	19427028
TR10B_HUMAN	TNFRSF10B	physical	19427028
CASP8_HUMAN	CASP8	physical	23142077
CFLAR_HUMAN	CFLAR	physical	23142077
FADD_HUMAN	FADD	physical	23142077
TRAF2_HUMAN	TRAF2	physical	23142077
CUL3_HUMAN	CUL3	physical	23142077
MARH1_HUMAN	MARCH1	physical	23300075
MARH8_HUMAN	MARCH8	physical	23300075
CFLAR_HUMAN	CFLAR	physical	27321185
FADD_HUMAN	FADD	physical	27321185
CASP8_HUMAN	CASP8	physical	27321185
CASP8_HUMAN	CASP8	physical	28514442
AL3B1_HUMAN	ALDH3B1	physical	28514442
FADD_HUMAN	FADD	physical	28514442
FGFR4_HUMAN	FGFR4	physical	28514442
ERG7_HUMAN	LSS	physical	28514442
ACVR1_HUMAN	ACVR1	physical	28514442
CEGT_HUMAN	UGCG	physical	28514442
INAR1_HUMAN	IFNAR1	physical	28514442
TR10B_HUMAN	TNFRSF10B	physical	28514442
KCNT2_HUMAN	KCNT2	physical	28514442
TMM94_HUMAN	KIAA0195	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
LAP4B_HUMAN	LAPTM4B	physical	28514442
S12A4_HUMAN	SLC12A4	physical	28514442
ABCD4_HUMAN	ABCD4	physical	28514442
MP3B2_HUMAN	MAP1LC3B2	physical	28514442
LRP10_HUMAN	LRP10	physical	28514442
CARME_HUMAN	C9orf41	physical	28514442
ST7L_HUMAN	ST7L	physical	28514442
RN149_HUMAN	RNF149	physical	28514442
BT2A2_HUMAN	BTN2A2	physical	28514442
CDC6_HUMAN	CDC6	physical	28514442
ATG9A_HUMAN	ATG9A	physical	28514442
UBB_HUMAN	UBB	physical	28514442
ERMP1_HUMAN	ERMP1	physical	28514442
S10AA_HUMAN	S100A10	physical	28514442
P4K2A_HUMAN	PI4K2A	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
CD320_HUMAN	CD320	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
IL4RA_HUMAN	IL4R	physical	28514442
DDRGK_HUMAN	DDRGK1	physical	28514442
AVR2A_HUMAN	ACVR2A	physical	28514442
SDCB1_HUMAN	SDCBP	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D04858	Mapatumumab (USAN/INN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TR10A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-463 AND SER-466,AND MASS SPECTROMETRY.	17081983 [Abstract]