MARH8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MARH8_HUMAN
• UniProt AC: Q5T0T0
• Protein Name: E3 ubiquitin-protein ligase MARCH8
• Gene Name: 8-Mar
• Organism: Homo sapiens (Human).
• Sequence Length: 291
• Subcellular Localization: Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein .
• Protein Description: E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS..
• Protein Sequence: MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSMPLHQIS ------CCCCHHHHC	29.16	24043423
9	Phosphorylation	SMPLHQISAIPSQDA CCCHHHHCCCCCHHH	17.36	24043423
13	Phosphorylation	HQISAIPSQDAISAR HHHCCCCCHHHHHHH	34.28	25348772
18	Phosphorylation	IPSQDAISARVYRSK CCCHHHHHHHHHHHH	16.25	25348772
22	Phosphorylation	DAISARVYRSKTKEK HHHHHHHHHHHCCHH	12.01	24043423
57	Phosphorylation	SKAGSPPSASAPAPV CCCCCCCCCCCCCCC	37.93	22210691
70	Phosphorylation	PVSSFSRTSITPSSQ CCCCCCCCCCCCCCC	24.23	30108239
71	Phosphorylation	VSSFSRTSITPSSQD CCCCCCCCCCCCCCC	24.29	30108239
73	Phosphorylation	SFSRTSITPSSQDIC CCCCCCCCCCCCCCH	19.51	26434776
75	Phosphorylation	SRTSITPSSQDICRI CCCCCCCCCCCCHHH	31.79	30108239
76	Phosphorylation	RTSITPSSQDICRIC CCCCCCCCCCCHHHH	32.83	26434776
237	Phosphorylation	KAYNRVIYVQNCPET HHCCCEEEEECCCCH	7.98	-
253	Phosphorylation	KKNIFEKSPLTEPNF CCCCCCCCCCCCCCC	20.25	30266825
256	Phosphorylation	IFEKSPLTEPNFENK CCCCCCCCCCCCCCC	53.43	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MARH8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MARH8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MARH8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD86_HUMAN	CD86	physical	12582153
IL1AP_HUMAN	IL1RAP	physical	22904187
UB2D3_HUMAN	UBE2D3	physical	22904187
TFR1_HUMAN	TFRC	physical	23606747
UBE2H_HUMAN	UBE2H	physical	14722266
UB2D1_HUMAN	UBE2D1	physical	14722266
MARH8_HUMAN	MARCH8	physical	28103160

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.